Icam1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Icam1
intercellular adhesion molecule 1
MGI:96392

35 phenotypes from 4 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Icam1^tm1Alb/Icam1^tm1Alb B6.Cg-Icam1^tm1Alb	abnormal leukocyte adhesion	J:100242
	abnormal leukocyte tethering or rolling	J:100242
	increased leukocyte cell number	J:100242
	increased neutrophil cell number	J:100242
Icam1^tm1Bay/Icam1^tm1Bay B6.129S7-Icam1^tm1Bay	abnormal cell migration	J:118196
	abnormal cell physiology	J:118196
	abnormal cellular extravasation	J:48271
	abnormal leukocyte migration	J:24239
	abnormal leukocyte tethering or rolling	J:48271
	abnormal nitric oxide homeostasis	J:118196
	decreased angiogenesis	J:118196
	decreased susceptibility to endotoxin shock	J:123460
	increased body weight	J:48271
	increased eosinophil cell number	J:48271
	increased lymphocyte cell number	J:48271
	increased monocyte cell number	J:48271
	increased neutrophil cell number	J:24239, J:48271
	increased tumor growth/size	J:108135
Icam1^tm1Bay/Icam1^tm1Bay B6.129S7-Icam1^tm1Bay/J	abnormal eye physiology	J:118466
	abnormal retina morphology	J:118466, J:119416
	abnormal retina vasculature morphology	J:118466
	decreased susceptibility to induced choroidal neovascularization	J:119416
	decreased susceptibility to parasitic infection induced morbidity/mortality	J:193592
	normal immune system phenotype	J:193592
	increased circulating glucose level	J:118466
	premature death	J:118466
Icam1^tm1Bay/Icam1^tm1Bay either: B6.129S7-Icam1^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)	abnormal leukocyte tethering or rolling	J:31374
	increased leukocyte cell number	J:31374
Icam1^tm1Bay/Icam1^tm1Bay involves: 129S7/SvEvBrd * C57BL/6	decreased susceptibility to induced colitis	J:111227
	impaired neutrophil recruitment	J:112286
	increased neutrophil cell number	J:112286
	large intestinal inflammation	J:111227
Icam1^tm1Bay/Icam1^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal cellular extravasation	J:14565
	abnormal immune system physiology	J:14565
	decreased susceptibility to type IV hypersensitivity reaction	J:14565
	increased neutrophil cell number	J:14565
Icam1^tm1Cws/Icam1^tm1Cws involves: C57BL/6	abnormal macrophage morphology	J:100353
Icam1^tm1Jcgr/Icam1^tm1Jcgr B6.129S4-Icam1^tm1Jcgr	normal immune system phenotype	J:113463
Icam1^tm1Jcgr/Icam1^tm1Jcgr B6.129S4-Icam1^tm1Jcgr/J	abnormal cardiac muscle contractility	J:114093
Icam1^tm1Jcgr/Icam1^tm1Jcgr involves: 129S4/SvJae * C57BL/6 * DBA/2	abnormal interleukin level	J:18743
	abnormal T cell physiology	J:18743
	abnormal tumor necrosis factor level	J:18743
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:18743
	decreased susceptibility to type IV hypersensitivity reaction	J:18743
	increased lymphocyte cell number	J:18743
	increased neutrophil cell number	J:18743

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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