Icam1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Icam1
intercellular adhesion molecule 1
MGI:96392

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Icam1^tm1Bay/Icam1^tm1Bay Sele^tm2Alb/Sele^tm2Alb Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6	decreased acute inflammation	J:112286
	impaired neutrophil chemotaxis	J:112286
	increased neutrophil cell number	J:112286
	normal integument phenotype	J:112286
	skin edema	J:112286
Icam1^tm1Bay/Icam1^tm1Bay Sell^tm1Tft/Sell^tm1Tft B6.129-Sell^tm1Tft Icam1^tm1Bay	abnormal cellular extravasation	J:48271
	abnormal inflammatory response	J:124291
	abnormal leukocyte tethering or rolling	J:48271
	abnormal macrophage physiology	J:124291
	abnormal mast cell physiology	J:124291
	decreased angiogenesis	J:124291
	decreased keratinocyte migration	J:124291
	delayed wound healing	J:124291
	impaired macrophage chemotaxis	J:124291
	impaired wound healing	J:124291
	increased body weight	J:48271
	increased eosinophil cell number	J:48271
	increased lymphocyte cell number	J:48271
	increased monocyte cell number	J:48271
	increased neutrophil cell number	J:48271
	increased tumor growth/size	J:108135
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay B6.129S7-Icam1^tm1Bay Selp^tm1Bay/J	edema	J:119906
	normal immune system phenotype	J:119906
	normal nervous system phenotype	J:119906
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay either: B6.129S7-Selp^tm1Bay Icam1^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)	impaired leukocyte tethering or rolling	J:31374
Icam1^tm1Bay/Icam1^tm1Bay Selp^tm1Bay/Selp^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal leukocyte migration	J:24239
	increased neutrophil cell number	J:24239
Icam1^tm1Jcgr/Icam1^tm1Jcgr Ldlr^tm1Her/Ldlr^tm1Her involves: 129S4/SvJae * 129S7/SvEvBrd	increased neutrophil cell number	J:69597
Icam1^tm1Jcgr/Icam1^tm1Jcgr Ldlr^tm1Her/Ldlr^tm1Her Vcam1^tm1Dmil/Vcam1^tm1Dmil involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	decreased circulating cholesterol level	J:69597
	decreased susceptibility to atherosclerosis	J:69597
	increased leukocyte cell number	J:69597
	increased lymphocyte cell number	J:69597
	increased monocyte cell number	J:69597
	increased neutrophil cell number	J:69597
Icam1^tm1Jcgr/Icam1^tm1Jcgr Tg(INS-Il10)#Sar/0 NOD.Cg-Icam1^tm1Jcgr Tg(INS-Il10)#Sar	decreased susceptibility to autoimmune diabetes	J:66103
	periinsulitis	J:66103
Icam1^tm1Jcgr/Icam1^tm1Jcgr Vcam1^tm1Dmil/Vcam1⁺ involves: 129S4/SvJae * C57BL/6	decreased cell chemotaxis	J:227109
Icam1^tm1Jcgr/Icam1^tm1Jcgr Vcam1^tm1Dmil/Vcam1^tm1Dmil involves: 129S4/SvJae * C57BL/6	decreased cell chemotaxis	J:227109
	impaired macrophage chemotaxis	J:227109

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24