Irf8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irf8
interferon regulatory factor 8
MGI:96395

53 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Irf8^tm1.1Hm/Irf8^tm1.1Hm involves: 129P2/OlaHsd * C57BL/6	abnormal spleen marginal zone morphology	J:168923
	decreased follicular B cell number	J:168923
	normal immune system phenotype	J:168923
	increased B cell number	J:168923
	increased B-2 B cell number	J:168923
	increased follicular B cell number	J:168923
	increased marginal zone B cell number	J:168923
	increased transitional stage B cell number	J:168923
Irf8^M1Btlr/Irf8^M1Btlr C57BL/6J-Irf8^M1Btlr	abnormal interferon secretion	J:166600
	decreased macrophage cell number	J:166600
	decreased monocyte cell number	J:166600
	increased neutrophil cell number	J:166600
Irf8^m2Btlr/Irf8^m2Btlr C57BL/6J-Irf8^m2Btlr	decreased CD8-positive, alpha-beta T cell number	J:274937
Irf8^m2Btlr/Irf8^m2Btlr C57BL/6J-Irf8^m2Btlr	increased CD4-positive, alpha-beta T cell number	J:274937
Irf8^myls/Irf8⁺ involves: BXH2/TyJ * C57BL/6	increased B cell number	J:168923
	increased B-1b cell number	J:168923
	increased follicular B cell number	J:168923
	increased transitional stage B cell number	J:168923
Irf8^myls/Irf8^myls involves: BALB/cJ * BXH2/TyJ-Irf8^myls	abnormal myelopoiesis	J:97931
Irf8^myls/Irf8^myls involves: BALB/cJ * BXH2/TyJ-Irf8^myls	enlarged spleen	J:97931
Irf8^{tm1b(KOMP)Wtsi}/Irf8^{tm1b(KOMP)Wtsi} C57BL/6N-Irf8^{tm1b(KOMP)Wtsi}/J	decreased circulating free fatty acids level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased fasting circulating glucose level	J:211773
	increased circulating sodium level	J:211773
	increased circulating total protein level	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
	thrombocytopenia	J:211773
Irf8^tm1Hor/Irf8⁺ either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal definitive hematopoiesis	J:36038
	increased chronic myelocytic leukemia incidence	J:36038
	premature death	J:36038
Irf8^tm1Hor/Irf8^tm1Hor B6.129P2-Irf8^tm1Hor	decreased follicular B cell number	J:168923
	increased B-1b cell number	J:168923
	increased marginal zone B cell number	J:168923
Irf8^tm1Hor/Irf8^tm1Hor either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal cytotoxic T cell physiology	J:36038
	abnormal erythropoiesis	J:36038
	abnormal megakaryocyte morphology	J:36038
	abnormal plasma cell number	J:36038
	decreased B cell number	J:36038
	decreased interferon-gamma secretion	J:36038
	decreased lymphocyte cell number	J:36038
	decreased T cell number	J:36038
	enlarged lymph nodes	J:36038
	hepatosplenomegaly	J:36038
	increased B cell number	J:36038
	increased bone marrow cell number	J:36038
	increased chronic myelocytic leukemia incidence	J:36038
	increased granulocyte number	J:36038
	increased immunoglobulin level	J:36038
	increased leukocyte cell number	J:36038
	increased lymphocyte cell number	J:36038
	increased lymphoma incidence	J:36038
	increased macrophage cell number	J:36038
	increased mature B cell number	J:36038
	increased spleen red pulp amount	J:36038
	increased spleen weight	J:36038
	increased susceptibility to induced morbidity/mortality	J:36038
	increased susceptibility to Riboviria infection	J:36038
	premature death	J:36038
	spleen hyperplasia	J:36038
Irf8^tm1Hor/Irf8^tm1Hor involves: 129P2/OlaHsd * C57BL/6	abnormal humoral immune response	J:181366
Irf8^tm2.1Hm/Irf8^tm2.1Hm involves: C57BL/6	no abnormal phenotype detected	J:218664

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