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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irf8
interferon regulatory factor 8
MGI:96395
53 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Irf8tm1.1Hm/Irf8tm1.1Hm
involves: 129P2/OlaHsd * C57BL/6 		abnormal spleen marginal zone morphology J:168923
decreased follicular B cell number J:168923
normal immune system phenotype J:168923
increased B cell number J:168923
increased B-2 B cell number J:168923
increased follicular B cell number J:168923
increased marginal zone B cell number J:168923
increased transitional stage B cell number J:168923
Irf8M1Btlr/Irf8M1Btlr
C57BL/6J-Irf8M1Btlr 		abnormal interferon secretion J:166600
decreased macrophage cell number J:166600
decreased monocyte cell number J:166600
increased neutrophil cell number J:166600
Irf8m2Btlr/Irf8m2Btlr
C57BL/6J-Irf8m2Btlr 		decreased CD8-positive, alpha-beta T cell number J:274937
increased CD4-positive, alpha-beta T cell number J:274937
Irf8myls/Irf8+
involves: BXH2/TyJ * C57BL/6 		increased B cell number J:168923
increased B-1b cell number J:168923
increased follicular B cell number J:168923
increased transitional stage B cell number J:168923
Irf8myls/Irf8myls
involves: BALB/cJ * BXH2/TyJ-Irf8myls 		abnormal myelopoiesis J:97931
enlarged spleen J:97931
Irf8tm1b(KOMP)Wtsi/Irf8tm1b(KOMP)Wtsi
C57BL/6N-Irf8tm1b(KOMP)Wtsi/J 		decreased circulating free fatty acids level J:211773
decreased erythrocyte cell number J:211773
decreased fasting circulating glucose level J:211773
increased circulating sodium level J:211773
increased circulating total protein level J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular volume J:211773
thrombocytopenia J:211773
Irf8tm1Hor/Irf8+
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal definitive hematopoiesis J:36038
increased chronic myelocytic leukemia incidence J:36038
premature death J:36038
Irf8tm1Hor/Irf8tm1Hor
B6.129P2-Irf8tm1Hor 		decreased follicular B cell number J:168923
increased B-1b cell number J:168923
increased marginal zone B cell number J:168923
Irf8tm1Hor/Irf8tm1Hor
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal cytotoxic T cell physiology J:36038
abnormal erythropoiesis J:36038
abnormal megakaryocyte morphology J:36038
abnormal plasma cell number J:36038
decreased B cell number J:36038
decreased interferon-gamma secretion J:36038
decreased lymphocyte cell number J:36038
decreased T cell number J:36038
enlarged lymph nodes J:36038
hepatosplenomegaly J:36038
increased B cell number J:36038
increased bone marrow cell number J:36038
increased chronic myelocytic leukemia incidence J:36038
increased granulocyte number J:36038
increased immunoglobulin level J:36038
increased leukocyte cell number J:36038
increased lymphocyte cell number J:36038
increased lymphoma incidence J:36038
increased macrophage cell number J:36038
increased mature B cell number J:36038
increased spleen red pulp amount J:36038
increased spleen weight J:36038
increased susceptibility to induced morbidity/mortality J:36038
increased susceptibility to Riboviria infection J:36038
premature death J:36038
spleen hyperplasia J:36038
Irf8tm1Hor/Irf8tm1Hor
involves: 129P2/OlaHsd * C57BL/6 		abnormal humoral immune response J:181366
Irf8tm2.1Hm/Irf8tm2.1Hm
involves: C57BL/6 		no abnormal phenotype detected J:218664
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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08/21/2024
MGI 6.24 		The Jackson Laboratory