Irf8 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irf8
interferon regulatory factor 8
MGI:96395

18 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Id2^tm1Gtbz/Id2^tm1Gtbz Irf8^tm1Hor/Irf8^tm1Hor involves: 129P2/OlaHsd * C57BL/6	abnormal bone marrow cell morphology/development	J:194760
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r BXH2/TyJ	abnormal myelopoiesis	J:97931
	decreased interferon-gamma secretion	J:97931
	decreased interleukin-12 secretion	J:97931
	enlarged spleen	J:97931
	increased chronic myelocytic leukemia incidence	J:97931
	increased susceptibility to bacterial infection	J:97931
	premature death	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: A/J * BXH2/TyJ	increased chronic myelocytic leukemia incidence	J:97931
	premature death	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BXH2/TyJ * C3H/HeJ	enlarged spleen	J:97931
	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BXH2/TyJ * C57BL/6J	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s involves: BXH2/TyJ * C57BL/6J	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^s/Slc11a1^s involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Irf8^tm1Hor/Irf8^tm1Hor Irf4^tm1Mak/Irf4^tm1Mak involves: 129P2/OlaHsd * C57BL/6	abnormal B cell differentiation	J:84577
	abnormal pre-B cell morphology	J:84577
	absent B cells	J:84577
	arrested B cell differentiation	J:84577
	decreased dendritic cell number	J:97716
	decreased IgM level	J:84577
	decreased lymphocyte cell number	J:84577
	decreased plasmacytoid dendritic cell number	J:97716
	decreased T cell number	J:84577
	increased pre-B cell number	J:84577

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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