Id3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Id3
inhibitor of DNA binding 3
MGI:96398

38 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2^tm1Xdz Id3^tm1Zhu/Id3^tm1Zhu involves: 129S4/SvJaeSor * C57BL/6	premature neuronal precursor differentiation	J:185426
Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Id3^tm2.1Zhu/Id3^tm2.1Zhu Tg(Lck-cre)#Zhu/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL	decreased T cell number	J:172701
Id1^tm1Zhu/Id1⁺ Id3^tm1Zhu/Id3⁺ Twist1^tm1Bhr/Twist1⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd	premature cranial suture closure	J:108218
Id1^tm1Zhu/Id1⁺ Id3^tm1Zhu/Id3^tm1Zhu involves: 129S1/Sv * 129S4/SvJaeSor	abnormal middle ear morphology	J:311050
	abnormal tumor vascularization	J:86480
	conductive hearing loss	J:311050
	decreased distortion product otoacoustic emission amplitude	J:311050
	decreased metastatic potential	J:86480
	decreased tumor growth/size	J:86480
	increased or absent threshold for auditory brainstem response	J:311050
	increased susceptibility to otitis media	J:311050
	middle ear effusion	J:311050
	tumor regression	J:86480
Id1^tm1Zhu/Id1^tm1Zhu Id3^tm1Zhu/Id3⁺ involves: 129S1/Sv * 129S4/SvJaeSor	abnormal middle ear morphology	J:311050
	conductive hearing loss	J:311050
	decreased distortion product otoacoustic emission amplitude	J:311050
	increased or absent threshold for auditory brainstem response	J:311050
	increased susceptibility to otitis media	J:311050
	middle ear effusion	J:311050
	normal vision/eye phenotype	J:170418
Id1^tm1Zhu/Id1^tm1Zhu Id3^tm1Zhu/Id3⁺ Twist1^tm1Bhr/Twist1⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd	normal skeleton phenotype	J:108218
Id1^tm1Zhu/Id1^tm1Zhu Id3^tm1Zhu/Id3^tm1Zhu either: (involves: 129S1/Sv * 129S4/SvJaeSor) or (involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6)	preweaning lethality, complete penetrance	J:44278
Id1^tm1Zhu/Id1^tm1Zhu Id3^tm1Zhu/Id3^tm1Zhu involves: 129S1/Sv * 129S4/SvJaeSor	abnormal brain vasculature morphology	J:86480
	abnormal embryonic/fetal subventricular zone morphology	J:86480
	abnormal neuronal precursor proliferation	J:86480, J:170418
	abnormal retina development	J:170418
	decreased angiogenesis	J:86480
	decreased brain size	J:86480
	decreased embryo weight	J:86480
	embryonic lethality during organogenesis, complete penetrance	J:86480, J:170418
	intracranial hemorrhage	J:86480
	microphthalmia	J:170418
	premature neuronal precursor differentiation	J:86480
	retina hypoplasia	J:170418
	small lens	J:170418
Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2⁺ Id3^tm1Zhu/Id3^tm1Zhu Tg(Nes-cre)1Kln/0 involves: 129S4/SvJaeSor * C57BL/6 * SJL	normal nervous system phenotype	J:185426
Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2^tm1Xdz Id3^tm1Zhu/Id3^tm1Zhu Tg(Nes-cre)1Kln/0 involves: 129S4/SvJaeSor * C57BL/6 * SJL	abnormal brain morphology	J:185426
	abnormal cell cycle	J:185426
	abnormal cortical ventricular zone morphology	J:185426
	abnormal neuron differentiation	J:185426
	abnormal neuronal precursor proliferation	J:185426
	enlarged brain ventricles	J:185426
	neonatal lethality, incomplete penetrance	J:185426
	premature neuronal precursor differentiation	J:185426
	thin external granule cell layer	J:185426
Id2^tm2.1Ago/Id2⁺ Id3^tm2.1Cmu/Id3⁺ involves: C57BL/6	normal immune system phenotype	J:179006
Id3^tm2.1Cmu/Id3^tm2.1Cmu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Cd4-cre)1Cwi/0 involves: 129S4/SvJaeSor * C57BL/6 * DBA/2	decreased thymocyte number	J:176462
	normal immune system phenotype	J:176462

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24