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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
MGI:96413
30 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Idh1tm1b(EUCOMM)Wtsi/Idh1tm1b(EUCOMM)Wtsi
C57BL/6N-Idh1tm1b(EUCOMM)Wtsi/Tcp 		decreased prepulse inhibition J:211773
preweaning lethality, incomplete penetrance J:211773
Idh1tm1Mak/Idh1tm1Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal common lymphocyte progenitor cell morphology J:186700
abnormal common myeloid progenitor cell morphology J:186700
normal hematopoietic system phenotype J:186700
increased hematopoietic stem cell number J:186700
Idh1tm1Mak/Idh1tm1Mak
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood homeostasis J:186700
abnormal bone marrow cell morphology/development J:186700
abnormal bone marrow cell physiology J:186700
abnormal myeloblast morphology/development J:186700
abnormal spleen morphology J:186700
anemia J:186700
decreased B cell number J:186700
decreased bone marrow cell number J:186700
decreased CD4-positive, alpha-beta T cell number J:186700
decreased CD8-positive, alpha-beta T cell number J:186700
decreased common myeloid progenitor cell number J:186700
decreased hematocrit J:186700
decreased hemoglobin content J:186700
enlarged spleen J:186700
extramedullary hematopoiesis J:186700
normal hematopoietic system phenotype J:186700
increased CD4-positive, alpha-beta T cell number J:186700
increased hematopoietic stem cell number J:186700
Idh1tm2Mak/Idh1tm2Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		abnormal common lymphocyte progenitor cell morphology J:186700
abnormal common myeloid progenitor cell morphology J:186700
normal hematopoietic system phenotype J:186700
increased hematopoietic stem cell number J:186700
Idh1tm2Mak/Idh1tm2Mak
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood homeostasis J:186700
abnormal bone marrow cell morphology/development J:186700
abnormal bone marrow cell physiology J:186700
abnormal myeloblast morphology/development J:186700
abnormal spleen morphology J:186700
anemia J:186700
decreased B cell number J:186700
decreased bone marrow cell number J:186700
decreased CD4-positive, alpha-beta T cell number J:186700
decreased CD8-positive, alpha-beta T cell number J:186700
decreased common myeloid progenitor cell number J:186700
decreased hematocrit J:186700
decreased hemoglobin content J:186700
enlarged spleen J:186700
extramedullary hematopoiesis J:186700
normal hematopoietic system phenotype J:186700
increased CD4-positive, alpha-beta T cell number J:186700
increased hematopoietic stem cell number J:186700
Idh1tm3Mak/Idh1+
Tg(Col2a1-cre)1Bhr/0
involves: C57BL/6 * SJL 		abnormal cartilage development J:220318
abnormal cartilage morphology J:220318
abnormal long bone epiphyseal plate morphology J:220318
abnormal tracheal cartilage morphology J:220318
decreased body size J:220318
pectus excavatum J:220318
postnatal lethality, complete penetrance J:220318
prenatal lethality, incomplete penetrance J:220318
Idh1tm3Mak/Idh1+
Tg(Col2a1-cre/ERT2)1Dic/0
involves: C57BL/6 		abnormal cartilage morphology J:220318
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory