Ido1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ido1
indoleamine 2,3-dioxygenase 1
MGI:96416

34 phenotypes from 2 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ido1^tm1.1Mkks/Ido1^tm1.1Mkks B6.Cg-Ido1^tm1.1Mkks	abnormal female reproductive system physiology	J:229059
	abnormal pregnancy	J:229059
	abnormal renal glomerulus morphology	J:229059
	abnormal vasodilation	J:229059
	decreased heart rate	J:229059
	increased systemic arterial blood pressure	J:229059
	increased urine protein level	J:229059
Ido1^tm1Alm/Ido1^tm1Alm either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CBA)	normal reproductive system phenotype	J:93797
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ	normal homeostasis/metabolism phenotype	J:177903
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * BALB/c	abnormal autophagy	J:170565
	abnormal caput epididymis morphology	J:170565
	abnormal cytokine level	J:170565
	abnormal protein level	J:170565
	decreased leukocyte cell number	J:170565
	enlarged sperm head	J:170565
	epididymis inflammation	J:170565
	hairpin sperm flagellum	J:170565
	increased sperm number	J:170565
	pinhead sperm	J:170565
	normal reproductive system phenotype	J:170565
	teratozoospermia	J:170565
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6 * CBA	abnormal cytokine secretion	J:120813
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6 * CBA	abnormal dendritic cell physiology	J:120813
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6J	abnormal blood homeostasis	J:282516
	abnormal macrophage morphology	J:282516
	abnormal macrophage physiology	J:282516
	abnormal mitochondrial morphology	J:282516
	abnormal mitophagy	J:282516
	abnormal oxidative phosphorylation	J:282516
	abnormal physiological response to xenobiotic	J:282516
	decreased mitochondrial number	J:282516
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6J * FVB/N	decreased susceptibility to type IV hypersensitivity reaction	J:211949
	increased interferon-gamma secretion	J:211949
	increased interleukin-6 secretion	J:211949
	increased tumor necrosis factor secretion	J:211949

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24