Ido1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ido1
indoleamine 2,3-dioxygenase 1
MGI:96416

34 phenotypes from 2 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ido1^tm1.1Mkks/Ido1^tm1.1Mkks B6.Cg-Ido1^tm1.1Mkks	abnormal female reproductive system physiology	J:229059
	abnormal pregnancy	J:229059
	abnormal renal glomerulus morphology	J:229059
	abnormal vasodilation	J:229059
	decreased heart rate	J:229059
	increased systemic arterial blood pressure	J:229059
	increased urine protein level	J:229059
Ido1^tm1Alm/Ido1^tm1Alm either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CBA)	normal reproductive system phenotype	J:93797
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ	normal homeostasis/metabolism phenotype	J:177903
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * BALB/c	abnormal autophagy	J:170565
	abnormal caput epididymis morphology	J:170565
	abnormal cytokine level	J:170565
	abnormal protein level	J:170565
	decreased leukocyte cell number	J:170565
	enlarged sperm head	J:170565
	epididymis inflammation	J:170565
	hairpin sperm flagellum	J:170565
	increased sperm number	J:170565
	pinhead sperm	J:170565
	normal reproductive system phenotype	J:170565
	teratozoospermia	J:170565
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6 * CBA	abnormal cytokine secretion	J:120813
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6 * CBA	abnormal dendritic cell physiology	J:120813
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6J	abnormal blood homeostasis	J:282516
	abnormal macrophage morphology	J:282516
	abnormal macrophage physiology	J:282516
	abnormal mitochondrial morphology	J:282516
	abnormal mitophagy	J:282516
	abnormal oxidative phosphorylation	J:282516
	abnormal physiological response to xenobiotic	J:282516
	decreased mitochondrial number	J:282516
Ido1^tm1Alm/Ido1^tm1Alm involves: 129X1/SvJ * C57BL/6J * FVB/N	decreased susceptibility to type IV hypersensitivity reaction	J:211949
	increased interferon-gamma secretion	J:211949
	increased interleukin-6 secretion	J:211949
	increased tumor necrosis factor secretion	J:211949

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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