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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igf1
insulin-like growth factor 1
MGI:96432
85 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Igf1tm1.1Dlr/Igf1tm1.1Dlr
involves: C57BL/6 * FVB/N 		abnormal body size J:69518
abnormal glucose homeostasis J:69518
decreased birth weight J:69518
decreased body length J:69518
decreased circulating glucose level J:69518
increased circulating growth hormone level J:69518
increased circulating insulin level J:69518
insensitivity to growth hormone J:69518
postnatal lethality, incomplete penetrance J:69518
premature death J:49468
prenatal lethality, incomplete penetrance J:69518
slow postnatal weight gain J:49468, J:69518
Igf1tm1.1Nros/Igf1tm1.1Nros
involves: BALB/c * C57BL/6 		decreased circulating insulin-like growth factor I level J:159167
normal growth/size/body region phenotype J:159167
normal mortality/aging J:159167
Igf1tm1Arge/Igf1+
involves: 129S/SvEv * MF1 		normal hearing/vestibular/ear phenotype J:105536
small cochlear ganglion J:71687
Igf1tm1Arge/Igf1tm1Arge
either: 129S/SvEv-Igf1tm1Arge or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1) 		decreased body size J:15108
delayed bone ossification J:15108
neonatal lethality, complete penetrance J:15108
postnatal growth retardation J:15108
Igf1tm1Arge/Igf1tm1Arge
involves: 129S/SvEv 		decreased motor neuron number J:103711
Igf1tm1Arge/Igf1tm1Arge
involves: 129S/SvEv * DBA * MF1 		abnormal chondrocyte morphology J:66913
abnormal long bone epiphyseal plate proliferative zone J:66913
abnormal long bone hypertrophic chondrocyte zone J:66913
abnormal trabecular bone morphology J:66913
decreased width of hypertrophic chondrocyte zone J:66913
delayed endochondral bone ossification J:66913
increased circulating growth hormone level J:66913
postnatal growth retardation J:66913
proportional dwarf J:66913
Igf1tm1Arge/Igf1tm1Arge
involves: 129S/SvEv * MF1 		abnormal auditory brainstem response waveform shape J:105536
abnormal cochlea morphology J:71687
abnormal cochlear ganglion morphology J:71687
abnormal cochlear nerve morphology J:71687
abnormal hair follicle development J:82113
abnormal lung morphology J:82113
abnormal mitral cell morphology J:82113
abnormal myelination J:71687
abnormal olfactory bulb external plexiform layer morphology J:82113
abnormal olfactory bulb layer morphology J:82113
abnormal olfactory bulb mitral cell layer morphology J:82113
abnormal otic capsule morphology J:71687
abnormal sensory neuron innervation pattern J:71687
abnormal skeleton morphology J:82113
abnormal tectorial membrane morphology J:71687
cochlear ganglion degeneration J:71687
decreased body weight J:71687, J:82113
delayed bone ossification J:82113
delayed inner ear development J:71687
disproportionate dwarf J:71687
increased neuron apoptosis J:71687
increased or absent threshold for auditory brainstem response J:105536
increased type II pneumocyte number J:82113
muscle hypoplasia J:82113
postnatal growth retardation J:71687
postnatal lethality, incomplete penetrance J:82113, J:105536
sensorineural hearing loss J:105536
small cochlear ganglion J:71687
syndromic hearing loss J:105536
Igf1tm1Dlr/Igf1tm1Dlr
Tg(Alb1-cre)1Dlr/0
involves: 129/Sv * C57BL/6 * FVB/N 		no abnormal phenotype detected J:69517
Igf1tm1Dlr/Igf1tm1Dlr
Tg(Alb1-cre)1Dlr/0
involves: 129/Sv * C57BL/6J * FVB/N 		decreased circulating insulin-like growth factor I level J:155733
decreased tumor growth/size J:155733
increased circulating leptin level J:155733
Igf1tm1Dlr/Igf1tm1Dlr
Tg(EIIa-cre)C5379Lmgd/0
involves: 129/Sv * C57BL/6 * FVB/N 		fetal growth retardation J:49468
perinatal lethality, incomplete penetrance J:49468
slow postnatal weight gain J:49468
Igf1tm1Dlr/Igf1tm1Dlr
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA 		decreased circulating insulin-like growth factor I level J:55718, J:121798
decreased kidney weight J:121798
normal growth/size/body region phenotype J:55718, J:121798
normal homeostasis/metabolism phenotype J:121798
increased circulating growth hormone level J:121798
increased systemic arterial systolic blood pressure J:121798
increased urine potassium level J:121798
increased urine sodium level J:121798
normal renal/urinary system phenotype J:121798
Igf1tm1Dlr/Igf1tm1Dlr
Tg(Serpina1e-cre/ERT)1Sykr/0
involves: 129/Sv * C57BL/6J * FVB/N 		decreased circulating insulin-like growth factor I level J:155733
normal homeostasis/metabolism phenotype J:155733
increased circulating insulin level J:155733
increased circulating leptin level J:155733
normal neoplasm J:155733
Igf1tm1Ts/Igf1+
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal postnatal growth/weight/body size J:16214
Igf1tm1Ts/Igf1tm1Ts
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal brain morphology J:24953
abnormal embryonic growth/weight/body size J:16214
abnormal muscle morphology J:16214
abnormal nervous system physiology J:24953
abnormal respiratory system morphology J:16214
abnormal respiratory system physiology J:16214
perinatal lethality J:16214
Igf1tm2.1Arge/Igf1tm2.1Arge
involves: 129S/SvEv * C57BL/6J * CBA 		decreased body weight J:142247
decreased circulating insulin-like growth factor I level J:142247
Igf1tm2.1Nros/Igf1+
involves: BALB/c * C57BL/6 		decreased birth weight J:159167
Igf1tm2.1Nros/Igf1tm2.1Nros
involves: BALB/c * C57BL/6 		abnormal lung morphology J:159167
decreased birth weight J:159167
neonatal lethality, complete penetrance J:159167
primary atelectasis J:159167
respiratory failure J:159167
Igf1tm2Arge/Igf1tm2.1Arge
involves: 129S/SvEv * C57BL/6J * CBA 		decreased body weight J:142247
decreased circulating insulin-like growth factor I level J:142247
Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0
involves: 129S/SvEv * C57BL/6J * CBA 		decreased body weight J:142247
decreased circulating insulin-like growth factor I level J:142247
Igf1tm2Arge/Igf1tm2Arge
involves: 129S/SvEv * C57BL/6J 		abnormal long bone epiphyseal plate proliferative zone J:142247
decreased body weight J:142247
decreased circulating insulin-like growth factor I level J:142247
decreased long bone epiphyseal plate size J:142247
decreased survivor rate J:142247
infertility J:142247
neonatal lethality, incomplete penetrance J:142247
postnatal growth retardation J:142247
Igf1tm2Arge/Igf1tm2Arge
Tg(SERPINA1-cre)1Arge/0
involves: 129S/SvEv * C57BL/6J 		decreased body weight J:142247
decreased circulating insulin-like growth factor I level J:142247
decreased survivor rate J:142247
neonatal lethality, incomplete penetrance J:142247
normal reproductive system phenotype J:142247
Igf1tm2Ts/Igf1tm2Ts
involves: 129S7/SvEvBrd * C57BL/6J 		decreased body weight J:37969
decreased circulating glucose level J:37969
decreased circulating growth hormone level J:37969
increased heart left ventricle muscle contractility J:37969
increased systemic arterial blood pressure J:37969
increased systemic arterial diastolic blood pressure J:37969
increased systemic arterial systolic blood pressure J:37969
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory