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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igf1
insulin-like growth factor 1
MGI:96432
78 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ghrtm1Arge/Ghrtm1Arge
Igf1tm1Arge/Igf1tm1Arge
involves: 129S/SvEv * C57BL/6J * DBA * MF1 		abnormal chondrocyte morphology J:66913
abnormal long bone epiphyseal plate proliferative zone J:66913
abnormal long bone hypertrophic chondrocyte zone J:66913
abnormal trabecular bone morphology J:66913
decreased width of hypertrophic chondrocyte zone J:66913
delayed endochondral bone ossification J:66913
postnatal growth retardation J:66913
proportional dwarf J:66913
Gpc3tm1Arge/Gpc3tm1Arge
Igf1tm1Arge/Igf1tm1Arge
involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1 		perinatal lethality, incomplete penetrance J:75054
postnatal lethality, complete penetrance J:75054
Gpc3tm1Arge/Y
Igf1tm1Arge/Igf1tm1Arge
involves: 129S/SvEv * 129S1/Sv * C57BL/6J * DBA * MF1 		perinatal lethality, incomplete penetrance J:75054
postnatal lethality, complete penetrance J:75054
Igf1tm1.1Dlr/Igf1tm1.1Dlr
Tg(Ttr-IGF1)1Sykr/0
FVB.Cg-Igf1tm1.1Dlr Tg(Ttr-IGF1)1Sykr 		abnormal branching of the mammary ductal tree J:157350
abnormal corpus luteum morphology J:157350
abnormal endometrial gland development J:157350
abnormal endometrium morphology J:157350
abnormal estrous cycle J:157350
abnormal insulin-like growth factor I level J:157350
abnormal mature ovarian follicle morphology J:157350
decreased birth body size J:157350
decreased circulating insulin level J:157350
decreased endometrial gland number J:157350
decreased gonadal fat pad weight J:157350
decreased litter size J:157350
decreased percent body fat/body weight J:157350
decreased total body fat amount J:157350
endometrium hypoplasia J:157350
normal homeostasis/metabolism phenotype J:157350
increased body length J:157350
increased circulating insulin-like growth factor I level J:157350
increased spleen weight J:157350
increased superovulation rate J:157350
normal mortality/aging J:157350
myometrium hypoplasia J:157350
ovary hypoplasia J:157350
prolonged diestrus J:157350
prolonged proestrus J:157350
reduced female fertility J:157350
short estrus J:157350
Igf1tm1Arge/Igf1+
Liftm1Stw/Lif+
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1 		increased growth hormone level J:87585
Igf1tm1Arge/Igf1+
Liftm1Stw/Liftm1Stw
involves: 129S/SvEv * 129S1/Sv 		decreased motor neuron number J:103711
Igf1tm1Arge/Igf1+
Liftm1Stw/Liftm1Stw
involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1 		postnatal lethality J:82113
Igf1tm1Arge/Igf1+
Liftm1Stw/Liftm1Stw
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1 		abnormal white fat cell morphology J:87585
decreased body mass index J:87585
decreased body weight J:87585
decreased gonadal fat pad weight J:87585
normal homeostasis/metabolism phenotype J:87585
increased circulating insulin-like growth factor I level J:87585
increased circulating leptin level J:87585
increased growth hormone level J:87585
slow postnatal weight gain J:87585
Igf1tm1Arge/Igf1tm1Arge
Igf1rtm1Arge/Igf1rtm1Arge
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1) 		decreased birth weight J:15108
delayed bone ossification J:15108
neonatal lethality, complete penetrance J:15108
respiratory failure J:15108
Igf1tm1Arge/Igf1tm1Arge
Igf2tm1Rob/Igf2+
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1) 		decreased birth weight J:15108
delayed bone ossification J:15108
maternal imprinting J:15108
neonatal lethality, complete penetrance J:15108
respiratory failure J:15108
thin epidermis stratum spinosum J:15108
Igf1tm1Arge/Igf1tm1Arge
Liftm1Stw/Lif+
involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1 		delayed bone ossification J:82113
postnatal lethality J:82113
Igf1tm1Arge/Igf1tm1Arge
Liftm1Stw/Liftm1Stw
involves: 129S/SvEv * 129S1/Sv 		abnormal cerebellar Purkinje cell layer J:103711
decreased motor neuron number J:103711
Igf1tm1Arge/Igf1tm1Arge
Liftm1Stw/Liftm1Stw
involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1 		abnormal keratinocyte morphology J:82113
abnormal long bone morphology J:82113
abnormal lung morphology J:82113
abnormal mitral cell morphology J:82113
abnormal olfactory bulb external plexiform layer morphology J:82113
abnormal olfactory bulb layer morphology J:82113
abnormal olfactory bulb mitral cell layer morphology J:82113
abnormal pulmonary alveolus morphology J:82113
abnormal skeleton morphology J:82113
abnormal type II pneumocyte morphology J:82113
absent type I pneumocytes J:82113
atelectasis J:82113
decreased body size J:82113
decreased body weight J:82113
decreased bone mineral density J:82113
delayed bone ossification J:82113
fragile skeleton J:82113
increased type II pneumocyte number J:82113
muscle hypoplasia J:82113
neonatal lethality, complete penetrance J:82113
thick pulmonary interalveolar septum J:82113
thin epidermis J:82113
underdeveloped hair follicles J:82113
Igf1tm1Dlr/Igf1tm1Dlr
Igfalstm1Yrb/Igfalstm1Yrb
Tg(Alb1-cre)1Dlr/?
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N 		abnormal femur morphology J:79109
abnormal limb bone morphology J:79109
abnormal long bone epiphyseal plate proliferative zone J:79109
decreased body length J:79109
decreased diameter of femur J:79109
decreased long bone epiphyseal plate size J:79109
decreased width of hypertrophic chondrocyte zone J:79109
short femur J:79109
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory