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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igf1r
insulin-like growth factor I receptor
MGI:96433
90 phenotypes from 8 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Igf1rhyft/Igf1rhyft
Not Specified 		abnormal liver morphology J:75360
hydrops fetalis J:75360
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
involves: 129/Sv * C57BL/6 * FVB/N 		normal growth/size/body region phenotype J:63460
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Tg(Ckmm-cre)5Khn/0
involves: 129/Sv * C57BL/6 * FVB 		normal growth/size/body region phenotype J:118987
normal homeostasis/metabolism phenotype J:118987
increased heart weight J:118987
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Tg(Ins2-cre)25Mgn/0
involves: 129/Sv * C57BL/6 * DBA/2 		normal digestive/alimentary phenotype J:121640
hyperglycemia J:121640
impaired glucose tolerance J:121640
normal mortality/aging J:121640
Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
involves: 129/Sv * C57BL/6 * FVB/N 		abnormal muscle morphology J:63460
decreased body weight J:63460
neonatal lethality, complete penetrance J:63460
respiratory failure J:63460
Igf1rtm1Arge/Igf1r+
involves: 129S/SvEv 		abnormal postnatal growth/weight/body size J:15108
Igf1rtm1Arge/Igf1rtm1Arge
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv 		decreased birth weight J:34584
Igf1rtm1Arge/Igf1rtm1Arge
involves: 129/Sv * 129S/SvEv 		decreased birth weight J:34584
Igf1rtm1Arge/Igf1rtm1Arge
involves: 129S/SvEv 		abnormal brainstem morphology J:15108
abnormal hair follicle morphology J:15108
abnormal spinal cord morphology J:15108
atelectasis J:15108
cyanosis J:15108
decreased birth weight J:15108
decreased hair follicle number J:15108
decreased oligodendrocyte progenitor number J:15108
delayed bone ossification J:15108
muscle hypoplasia J:15108
neonatal lethality, complete penetrance J:15108
respiratory failure J:15108
small hair follicles J:15108
thin epidermis J:15108
thin epidermis stratum spinosum J:15108
translucent skin J:15108
Igf1rtm1Arge/Igf1rtm2Arge
Tg(Camk2a-cre)2Szi/0
involves: 129S/SvEv * C57BL/6J * CBA 		abnormal CNS glial cell morphology J:88198
abnormal myelination J:88198
abnormal oligodendrocyte morphology J:88198
decreased oligodendrocyte progenitor number J:88198
Igf1rtm1Jcbr/Igf1rtm1Jcbr
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
B6.Cg-Ndor1Tg(UBC-cre/ERT2)1Ejb Igf1rtm1Jcbr 		abnormal susceptibility to injury induced morbidity/mortality J:241920
decreased airway responsiveness J:241924
decreased collagen level J:241924
decreased respiratory mucosa goblet cell number J:241924
decreased susceptibility to injury J:241920
decreased susceptibility to type I hypersensitivity reaction J:241924
Igf1rtm1Jcbr/Igf1rtm1Jcbr
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * C57BL/6 		abnormal bronchiole epithelium morphology J:221618
abnormal pulmonary alveolar parenchyma morphology J:221618
abnormal spermatogenesis J:221618
azoospermia J:221618
decreased body weight J:221618
decreased testis weight J:221618
increased hepatocyte proliferation J:221618
oligozoospermia J:221618
postnatal growth retardation J:221618
normal reproductive system phenotype J:221618
small seminiferous tubules J:221618
Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Fabp4-cre)1Abel/?
involves: C57BL/6 * FVB/N 		abnormal fat cell morphology J:141321
abnormal glucose homeostasis J:141321
abnormal gonadal fat pad morphology J:141321
decreased adiponectin level J:141321
decreased brain size J:141321
increased body length J:141321
increased body weight J:141321
increased circulating glucose level J:141321
increased fat cell size J:141321
increased heart weight J:141321
increased insulin sensitivity J:141321
increased liver weight J:141321
increased total body fat amount J:141321
Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Nkx2-1-cre)2Sand/0
involves: C57BL/6 		abnormal bronchiole epithelium morphology J:241923
abnormal response to injury J:241923
increased body weight J:241923
Igf1rtm1Jcbr/Igf1rtm1Jcbr
Tg(Scgb1a1-cre)1Tauc/0
involves: C57BL/6 		abnormal bronchiole epithelium morphology J:241923
abnormal response to injury J:241923
Igf1rtm1Mhz/Igf1rtm1Mhz
involves: 129/Sv * C57BL/6 		decreased body weight J:63460
normal homeostasis/metabolism phenotype J:63460
postnatal growth retardation J:63460
Igf1rtm2.1Arge/Igf1rtm2.1Arge
involves: 129 * C57BL/6 		abnormal bony labyrinth J:178908
abnormal cochlea morphology J:178908
abnormal cochlear hair cell development J:178908
abnormal cochlear hair cell stereociliary bundle morphology J:178908
abnormal cochlear inner hair cell morphology J:178908
abnormal cochlear outer hair cell morphology J:178908
abnormal cochlear sensory epithelium morphology J:178908
abnormal inner hair cell kinocilium morphology J:178908
abnormal lateral semicircular canal morphology J:178908
abnormal posterior semicircular canal morphology J:178908
abnormal semicircular canal morphology J:178908
decreased cochlear hair cell number J:178908
decreased cochlear inner hair cell number J:178908
decreased cochlear outer hair cell number J:178908
neonatal lethality, complete penetrance J:178908
prenatal growth retardation J:178908
respiratory failure J:178908
Igf1rtm2Arge/Igf1r+
Tg(Tek-cre)1Ywa/0
B6.Cg-Tg(Tek-cre)1Ywa Igf1rtm2Arge 		abnormal vascular endothelial cell physiology J:208523
abnormal vascular wound healing J:208523
Igf1rtm2Arge/Igf1rtm2Arge
Tg(BGLAP-cre)1Clem/0
involves: 129 * FVB/N 		abnormal osteoblast physiology J:80190
abnormal osteoclast physiology J:80190
abnormal skeleton morphology J:80190
abnormal skeleton physiology J:80190
abnormal trabecular bone morphology J:80190
decreased bone mineralization J:80190
decreased bone ossification J:80190
decreased bone trabecula number J:80190
decreased osteoblast cell number J:80190
decreased osteoclast cell number J:80190
decreased trabecular bone thickness J:80190
decreased trabecular bone volume J:80190
thin neurocranium J:80190
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory