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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igf2
insulin-like growth factor 2
MGI:96434
66 phenotypes from 8 alleles in 15 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Igf2tm1Rob/Igf2+
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv 		decreased birth weight J:34584
small placenta J:34584
Igf2tm1Rob/Igf2+
involves: 129S/SvEv 		decreased body weight J:10453, J:11007, J:15108, J:25091, J:75054
delayed bone ossification J:15108
maternal imprinting J:11007, J:15108
Igf2tm1Rob/Igf2+
involves: 129S/SvEv * BALB/c 		decreased body weight J:11007
maternal imprinting J:11007
Igf2tm1Rob/Igf2+
involves: 129S/SvEv * C57BL/6 * DBA/2J 		decreased body weight J:11007
maternal imprinting J:11007
Igf2tm1Rob/Igf2+
involves: 129S/SvEv * C57BL/6J 		abnormal circulating hormone level J:77413
abnormal fetal cardiomyocyte proliferation J:77413
abnormal heart morphology J:77413
abnormal heart septum morphology J:77413
abnormal heart ventricle morphology J:77413
abnormal lens morphology J:77413
abnormal lumbar vertebrae morphology J:77413
abnormal sternum morphology J:77413
abnormal xiphoid process morphology J:77413
adrenal gland cyst J:77413
decreased kidney weight J:77413
delayed eyelid fusion J:77413
increased fetal weight J:77413
increased heart weight J:77413
increased hepatocyte proliferation J:77413
increased liver weight J:77413
increased placenta weight J:77413
lethality throughout fetal growth and development, incomplete penetrance J:77413
omphalocele J:77413
polydactyly J:77413
postnatal lethality, complete penetrance J:77413
Igf2tm1Rob/Igf2+
involves: 129S/SvEv * MF1 		decreased body weight J:11007
maternal imprinting J:11007
Igf2tm1Rob/Igf2tm1Rob
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv 		decreased birth weight J:34584
small placenta J:34584
Igf2tm1Rob/Igf2tm4.1Wrk
involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 		abnormal imprinting J:178292
normal growth/size/body region phenotype J:169366
Igf2tm1Snha/Igf2+
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal bone marrow cavity morphology J:167738
abnormal bone trabecula morphology J:167738
abnormal cartilage development J:167738
abnormal compact bone lamellar structure J:167738
abnormal osteoblast differentiation J:167738
abnormal osteoclast differentiation J:167738
abnormal skeleton development J:167738
abnormal skeleton morphology J:167738
abnormal tibia morphology J:167738
decreased birth weight J:167738
decreased bone mineral density J:167738
decreased osteoblast cell number J:167738
delayed bone ossification J:167738
embryonic growth retardation J:167738
fetal growth retardation J:167738
increased compact bone thickness J:167738
maternal imprinting J:167738
postnatal growth retardation J:167738
Igf2tm1Wrk/Igf2+
involves: 129P2/Ola * C57BL/6J 		abnormal placental transport J:77386, J:90697
abnormal postnatal growth J:65001
abnormal prenatal growth/weight/body size J:77386
decreased birth body size J:65001
decreased fetal weight J:90697
decreased placenta weight J:90697
embryonic growth retardation J:77386
maternal imprinting J:65001, J:90697
small placenta J:77386, J:90697
Igf2tm2Wrk/Igf2+
involves: 129S1/Sv * C57BL/6 		decreased body size J:94521
maternal imprinting J:94521
Igf2tm3Wrk/Igf2+
Not Specified 		decreased body size J:94521
maternal imprinting J:94521
Igf2tm4.1Wrk/Igf2+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SD7 		abnormal imprinting J:178292
Igf2tm4Wrk/Igf2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal imprinting J:169366
decreased birth weight J:169366
prenatal growth retardation J:169366
Tg(Ins-Igf2)1Fbos/0
involves: C57BL/6 * C57BLKs/J * SJL 		disorganized pancreatic islets J:141527
hepatic steatosis J:141527
hyperglycemia J:141527
increased circulating free fatty acids level J:141527
increased circulating insulin level J:141527
increased circulating triglyceride level J:141527
insulin resistance J:141527
obese J:141527
pancreatic islet hyperplasia J:141527
Tg(Ins-Igf2)1Fbos/0
involves: C57BL/6 * SJL 		abnormal pancreatic beta cell physiology J:141527
decreased susceptibility to weight gain J:141527
disorganized pancreatic islets J:141527
hyperglycemia J:141527
increased circulating free fatty acids level J:141527
increased circulating glucose level J:141527
increased circulating insulin level J:141527
increased circulating triglyceride level J:141527
increased insulin secretion J:141527
increased pancreas weight J:141527
increased pancreatic beta cell mass J:141527
insulin resistance J:141527
pancreatic islet hyperplasia J:141527
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory