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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igf2r
insulin-like growth factor 2 receptor
MGI:96435
73 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Igf2rtm1.1Rlj/\Igf2r+
involves: 129/Sv * BALB/cJ * C57BL/6J 		abnormal lung development J:80932
enlarged placenta J:80932
genetic imprinting J:80932
impaired branching involved in preterminal bronchiole morphogenesis J:80932
increased embryo size J:80932
kinked tail J:80932
prenatal lethality, complete penetrance J:80932
short tail J:80932
\Igf2rtm1Arge/\Igf2r+
involves: 129 		abnormal body water content J:34584
abnormal circulating hormone level J:34584
abnormal uterus morphology J:34584
congestive heart failure J:34584
decreased survivor rate J:34584
dilated heart left ventricle J:34584
dilated heart right ventricle J:34584
edema J:34584
enlarged heart J:34584
enlarged kidney J:34584
enlarged liver J:34584
enlarged lung J:34584
enlarged placenta J:34584
enlarged uterus J:34584
heart hyperplasia J:34584
increased birth body size J:34584
increased brain size J:34584
increased embryo size J:34584
increased fetal size J:34584
increased heart left ventricle wall thickness J:34584
increased heart weight J:34584
increased nucleated erythrocyte cell number J:34584
kinked tail J:34584
liver hyperplasia J:34584
perinatal lethality, incomplete penetrance J:34584
polydactyly J:34584
postnatal lethality, incomplete penetrance J:34584
pulmonary hyperplasia J:34584
reduced female fertility J:34584
reduced male fertility J:34584
thick interventricular septum J:34584
vagina atresia J:34584
\Igf2rtm1Arge/\Igf2r+
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv 		increased birth weight J:34584
\Igf2rtm1Arge/\Igf2r+
involves: 129/Sv * C57BL/6J * MF1 		decreased survivor rate J:34584
lethality throughout fetal growth and development, incomplete penetrance J:34584
postnatal lethality, incomplete penetrance J:34584
\Igf2rtm1Arge/\Igf2r+
involves: 129/Sv * MF1 		decreased survivor rate J:34584
postnatal lethality, incomplete penetrance J:34584
\Igf2rtm1Arge/\Igf2rtm1Arge
involves: 129 		abnormal body water content J:34584
abnormal circulating hormone level J:34584
abnormal uterus morphology J:34584
congestive heart failure J:34584
decreased survivor rate J:34584
dilated heart left ventricle J:34584
dilated heart right ventricle J:34584
edema J:34584
enlarged heart J:34584
enlarged kidney J:34584
enlarged liver J:34584
enlarged lung J:34584
enlarged placenta J:34584
enlarged uterus J:34584
heart hyperplasia J:34584
increased birth body size J:34584
increased brain size J:34584
increased embryo size J:34584
increased fetal size J:34584
increased heart left ventricle wall thickness J:34584
increased heart weight J:34584
increased nucleated erythrocyte cell number J:34584
kinked tail J:34584
liver hyperplasia J:34584
perinatal lethality, incomplete penetrance J:34584
polydactyly J:34584
postnatal lethality, incomplete penetrance J:34584
pulmonary hyperplasia J:34584
reduced female fertility J:34584
reduced male fertility J:34584
thick interventricular septum J:34584
vagina atresia J:34584
\Igf2rtm1Arge/\Igf2rtm1Arge
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv 		increased birth weight J:34584
\Igf2rtm1Arge/\Igf2rtm1Arge
involves: 129/Sv * C57BL/6J * MF1 		postnatal lethality, complete penetrance J:34584
\Igf2rtm1Rlj/\Igf2r+
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129/Sv * C57BL/6 * DBA 		genetic imprinting J:80932
normal liver/biliary system phenotype J:80932
no abnormal phenotype detected J:80932
\Igf2rtm1Rlj/\Igf2r+
\Tg(Ckmm-cre)1Lrsn/0
involves: 129 * C57BL/6J 		genetic imprinting J:80932
no abnormal phenotype detected J:80932
\Igf2rtm1Stw/\Igf2r+
involves: 129S1/Sv * C57BL/6 		abnormal circulating hormone level J:22124
abnormal external female genitalia morphology J:22124
abnormal interventricular septum morphology J:22124
abnormal motor capabilities/coordination/movement J:22124
abnormal myocardium layer morphology J:22124
abnormal tricuspid valve development J:22124
absent endometrial glands J:22124
absent suckling reflex J:22124
cyanosis J:22124
decreased survivor rate J:22124
enlarged heart J:22124
enlarged uterus J:22124
female infertility J:22124
normal homeostasis/metabolism phenotype J:22124
increased birth body size J:22124
increased heart right ventricle size J:22124
increased heart weight J:22124
increased placenta weight J:22124
kinked tail J:22124
neonatal lethality, incomplete penetrance J:22124
reduced male fertility J:22124
respiratory distress J:22124
respiratory failure J:22124
thin endometrium J:22124
vagina atresia J:22124
\Igf2rtm1Stw/\Igf2rtm1Stw
involves: 129S1/Sv * C57BL/6 		kinked tail J:22124
neonatal lethality, complete penetrance J:22124
\Igf2rtm1Wag/\Igf2r+
involves: 129S2/SvPas 		abnormal bone ossification J:20763
abnormal craniofacial morphology J:20763
abnormal embryonic growth/weight/body size J:20763
abnormal lung morphology J:20763
abnormal lysosome physiology J:20763
disorganized myocardium J:20763
enlarged heart J:20763
enlarged uterus J:20763
kinked tail J:20763
maternal imprinting J:20763
perinatal lethality, incomplete penetrance J:20763
polydactyly J:20763
postnatal lethality, complete penetrance J:20763
premature bone ossification J:20763
respiratory failure J:20763
split sternum J:20763
vagina atresia J:20763
\Igf2rtm1Wag/\Igf2rtm1Wag
involves: 129S2/SvPas 		abnormal bone ossification J:20763
abnormal embryonic growth/weight/body size J:20763
abnormal lung morphology J:20763
abnormal lysosome physiology J:20763
disorganized myocardium J:20763
enlarged heart J:20763
kinked tail J:20763
neonatal lethality, complete penetrance J:20763
polydactyly J:20763
premature bone ossification J:20763
respiratory failure J:20763
short sternum J:20763
\Igf2rtm1Wag/\Igf2rtm2Wag
involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		normal growth/size/body region phenotype J:68721
normal mortality/aging J:68721
normal reproductive system phenotype J:68721
\Igf2rtm2Arge/\Igf2r+
involves: 129 		abnormal body water content J:34584
abnormal circulating hormone level J:34584
abnormal uterus morphology J:34584
congestive heart failure J:34584
decreased survivor rate J:34584
dilated heart left ventricle J:34584
dilated heart right ventricle J:34584
edema J:34584
enlarged heart J:34584
enlarged kidney J:34584
enlarged liver J:34584
enlarged lung J:34584
enlarged placenta J:34584
enlarged uterus J:34584
heart hyperplasia J:34584
increased birth body size J:34584
increased brain size J:34584
increased embryo size J:34584
increased fetal size J:34584
increased heart left ventricle wall thickness J:34584
increased heart weight J:34584
increased nucleated erythrocyte cell number J:34584
kinked tail J:34584
liver hyperplasia J:34584
perinatal lethality, incomplete penetrance J:34584
polydactyly J:34584
postnatal lethality, incomplete penetrance J:34584
pulmonary hyperplasia J:34584
reduced female fertility J:34584
reduced male fertility J:34584
thick interventricular septum J:34584
vagina atresia J:34584
\Igf2rtm2Arge/\Igf2r+
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv 		increased birth weight J:34584
\Igf2rtm2Arge/\Igf2r+
involves: 129/Sv * C57BL/6J * MF1 		decreased survivor rate J:34584
lethality throughout fetal growth and development, incomplete penetrance J:34584
postnatal lethality, incomplete penetrance J:34584
\Igf2rtm2Arge/\Igf2r+
involves: 129/Sv * MF1 		decreased survivor rate J:34584
postnatal lethality, incomplete penetrance J:34584
\Igf2rtm2Arge/\Igf2rtm2Arge
involves: 129 		abnormal body water content J:34584
abnormal circulating hormone level J:34584
abnormal uterus morphology J:34584
congestive heart failure J:34584
decreased survivor rate J:34584
dilated heart left ventricle J:34584
dilated heart right ventricle J:34584
edema J:34584
enlarged heart J:34584
enlarged kidney J:34584
enlarged liver J:34584
enlarged lung J:34584
enlarged placenta J:34584
enlarged uterus J:34584
heart hyperplasia J:34584
increased birth body size J:34584
increased brain size J:34584
increased embryo size J:34584
increased fetal size J:34584
increased heart left ventricle wall thickness J:34584
increased heart weight J:34584
increased nucleated erythrocyte cell number J:34584
kinked tail J:34584
liver hyperplasia J:34584
perinatal lethality, incomplete penetrance J:34584
polydactyly J:34584
postnatal lethality, incomplete penetrance J:34584
pulmonary hyperplasia J:34584
reduced female fertility J:34584
reduced male fertility J:34584
thick interventricular septum J:34584
vagina atresia J:34584
\Igf2rtm2Arge/\Igf2rtm2Arge
involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv 		increased birth weight J:34584
\Igf2rtm2Arge/\Igf2rtm2Arge
involves: 129/Sv * C57BL/6J * MF1 		postnatal lethality, complete penetrance J:34584
\Igf2rtm2Wag/\Igf2r+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		decreased fetal weight J:68721
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory