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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igh
immunoglobulin heavy chain complex
MGI:96442
78 phenotypes from 45 alleles in 32 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
IghdeltaD/Igh+
involves: C57BL/6 * DBA/2 		abnormal B cell differentiation J:95981
decreased B cell number J:95981
decreased immunoglobulin level J:95981
IghdeltaD/IghdeltaD
involves: C57BL/6 * DBA/2 		abnormal B cell differentiation J:95981
abnormal immunoglobulin level J:95981
abnormal spleen morphology J:95981
arrested B cell differentiation J:95981
decreased B cell number J:95981
decreased follicular B cell number J:95981
decreased IgG1 level J:95981
increased IgA level J:95981
increased marginal zone B cell number J:95981
Ightm1.1Cog/Ightm1.1Cog
involves: 129S2/SvPas * C57BL/6 * FVB/N 		no abnormal phenotype detected J:80654
Ightm1.1Hmj/Ightm1.1Hmj
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal B cell differentiation J:140486
abnormal immunoglobulin heavy chain V(D)J recombination J:140486
decreased mature B cell number J:140486
normal immune system phenotype J:140486
spleen hypoplasia J:140486
Ightm1.1Hws/Ightm1.1Hws
BALB/cJ-Ightm1.1Hws 		decreased IgM level J:119391
decreased immature B cell number J:119391
decreased immunoglobulin level J:119391
decreased pre-B cell number J:119391
increased late pro-B cell number J:119391
Ightm1.1Hws/Ightm1.1Hws
involves: BALB/c 		decreased immature B cell number J:142069
decreased late pro-B cell number J:142069
increased early pro-B cell number J:142069
increased IgG3 level J:142069
increased IgM level J:142069
Ightm1.1Lnit/Igh+
involves: BALB/c * C57BL/6 		abnormal B cell differentiation J:119484
Ightm1.1Rsky/Ightm1.1Rsky
BALB/c-Ightm1.1Rsky 		abnormal class switch recombination J:125719
decreased IgM level J:125719
Ightm1.1Twin/Igh+
involves: 129 * 129S4/SvJae * C57BL/6 		decreased pre-B cell number J:174233
increased pro-B cell number J:174233
Ightm1.1Twin/Ightm1.1Twin
involves: 129 * 129S4/SvJae * C57BL/6 		abnormal B cell differentiation J:174233
abnormal B cell morphology J:174233
abnormal B cell number J:174233
abnormal marginal zone B cell morphology J:174233
abnormal marginal zone B cell physiology J:174233
absent plasma cells J:174233
decreased B cell number J:174233
decreased B-1a cell number J:174233
decreased follicular B cell number J:174233
decreased IgG3 level J:174233
decreased IgG level J:174233
decreased IgM level J:174233
decreased immature B cell number J:174233
decreased mature B cell number J:174233
decreased transitional stage T2 B cell number J:174233
normal immune system phenotype J:174233
Ightm1.1Vmd/Igh+
involves: C57BL/6 		abnormal class switch recombination J:201147
Ightm1.1Vmd/Ightm1.1Vmd
involves: C57BL/6 		abnormal class switch recombination J:201147
decreased IgG1 level J:201147
decreased IgG3 level J:201147
normal immune system phenotype J:201147
increased IgE level J:201147
Ightm1.2Rsky/Igh+
BALB/c-Ightm1.2Rsky 		increased IgG1 level J:125719
Ightm1.2Rsky/Ightm1.2Rsky
BALB/c-Ightm1.2Rsky 		abnormal B cell activation J:125719
abnormal B cell morphology J:125719
abnormal B cell proliferation J:125719
abnormal mature B cell morphology J:125719
decreased B-1a cell number J:125719
decreased IgA level J:125719
decreased IgD level J:125719
decreased IgE level J:125719
decreased IgM level J:125719
decreased immunoglobulin level J:125719
decreased pre-B cell number J:125719
decreased transitional stage B cell number J:125719
increased marginal zone B cell number J:125719
increased pro-B cell number J:125719
Ightm1.2Rsky/Ightm1.2Rsky
Tg(CD19-cre/ERT2)1Cgn/?
involves: BALB/c 		abnormal B cell activation J:125719
abnormal class switch recombination J:125719
Ightm1Aak/Ightm1Aak
Not Specified 		abnormal B cell differentiation J:158402
decreased B cell number J:158402
decreased pre-B cell number J:158402
increased pro-B cell number J:158402
Ightm1Cgn/Igh+
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:79556
Ightm1Cgn/Ightm2Cgn
involves: 129P2/OlaHsd * BALB/c * C57BL/Ka 		abnormal B cell differentiation J:79556
Ightm1Cog/Ightm1Cog
involves: 129S2/SvPas * C57BL/6 		abnormal immunoglobulin heavy chain V(D)J recombination J:80654
absent B cells J:80654
arrested B cell differentiation J:80654
decreased IgA level J:80654
decreased IgE level J:80654
decreased IgG1 level J:80654
decreased IgG2a level J:80654
decreased IgG2b level J:80654
decreased IgG3 level J:80654
decreased IgM level J:80654
decreased immunoglobulin level J:80654
Ightm1Emo/Ightm1Emo
involves: 129S1/Sv * C57BL/6 * FVB/N 		normal immune system phenotype J:108098
Ightm1Kplm/Igh+
involves: A/WySnJ * BALB/c 		abnormal B-1 B cell morphology J:115788
Ightm1Kplm/Igh+
Not Specified 		abnormal B cell differentiation J:115292
increased B cell number J:115292
Ightm1Kplm/Ightm3Cgn
involves: C57BL/6 		abnormal B cell differentiation J:115292
abnormal B cell number J:115292
Ightm1Kplm/Ightm4Cgn
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:115292
abnormal B cell number J:115292
abnormal B-1 B cell morphology J:115292
Ightm1Ktom/Ightm1Ktom
involves: ICR 		abnormal B cell physiology J:59894
abnormal immunoglobulin level J:178635
absent mature B cells J:178635
Ightm1Mnz/Ightm1Mnz
B6.129P2-Ightm1Mnz 		abnormal B cell physiology J:75653
abnormal cell cycle J:75653
increased B cell apoptosis J:75653
increased B cell proliferation J:75653
increased IgG level J:75653
increased IgM level J:75653
Ightm1Rbr/Igh+
C57BL/6-Ightm1Rbr 		abnormal B cell morphology J:132538
Ightm2.1Fwa/Ightm2.1Fwa
involves: 129S/SvEv * C57BL/6 		abnormal class switch recombination J:161437
abnormal somatic hypermutation frequency J:161437
decreased IgG1 level J:161437
decreased mature B cell number J:161437
normal immune system phenotype J:161437
increased IgE level J:161437
Ightm2.1Hws/Ightm2.1Hws
involves: BALB/c 		abnormal B cell differentiation J:142069
decreased B-1a cell number J:142069
decreased follicular B cell number J:142069
decreased IgM level J:142069
decreased immature B cell number J:142069
decreased late pro-B cell number J:142069
decreased mature B cell number J:142069
decreased transitional stage B cell number J:142069
increased anti-nuclear antigen antibody level J:142069
increased early pro-B cell number J:142069
increased marginal zone B cell number J:142069
Ightm2.1Hws/Ightm2.1Hws
involves: BALB/c * C57BL/6NCrl * DBA/2NCrl 		abnormal humoral immune response J:124421
decreased B cell number J:124421
decreased B-1a cell number J:124421
decreased B-1b cell number J:124421
decreased follicular B cell number J:124421
decreased IgG level J:124421
decreased IgM level J:124421
decreased pre-B cell number J:124421
decreased transitional stage B cell number J:124421
increased early pro-B cell number J:124421
increased marginal zone B cell number J:124421
Ightm2Cgn/Igh+
involves: 129P2/OlaHsd * BALB/c * C57BL/Ka 		abnormal B cell differentiation J:79556
Ightm2Cgn/Igh+
involves: 129P2/OlaHsd * C57BL/6 		abnormal immunoglobulin light chain V-J recombination J:144033
Ightm2Cgn/Ightm3Cgn
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/Ka 		abnormal B cell differentiation J:79556
Ightm2Cgn/Ightm4.1Fwa
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal immunoglobulin V(D)J recombination J:176649
Ightm2Cog/Igh+
involves: 129S2/SvPas * C57BL/6 		decreased IgG1 level J:90548
decreased IgG2b level J:90548
decreased IgG3 level J:90548
decreased IgG level J:90548
Ightm2Cog/Ightm2Cog
involves: 129S2/SvPas * C57BL/6 		decreased IgG1 level J:90548
decreased IgG2a level J:90548
decreased IgG2b level J:90548
decreased IgG3 level J:90548
decreased IgG level J:90548
increased pre-B cell number J:90548
Ightm2Emo/Ightm2Emo
involves: 129S1/Sv * C57BL/6 * FVB/N 		abnormal B cell differentiation J:108098
absent pre-B cells J:108098
Ightm2Mnz/Ightm2Mnz
B6.129P2-Ightm2Mnz 		normal cellular phenotype J:75653
increased B cell proliferation J:75653
increased IgG level J:75653
increased IgM level J:75653
Ightm3.1Cog/Ightm3.1Cog
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal class switch recombination J:71300
decreased IgA level J:71300
decreased IgE level J:71300
decreased IgG2a level J:71300
decreased IgG2b level J:71300
decreased IgG3 level J:71300
decreased IgG level J:71300
decreased immunoglobulin level J:71300
normal immune system phenotype J:71300
Ightm3Cgn/Igh+
involves: C57BL/6 		abnormal B cell differentiation J:79556, J:115292
Ightm3Cgn/Ightm3Cgn
involves: C57BL/6 		abnormal immune system physiology J:76117
decreased immature B cell number J:76117
Ightm3Hws/Ightm3Hws
BALB/c-Ightm3Hws 		abnormal immunoglobulin heavy chain V(D)J recombination J:142068
Ightm3Hws/Ightm3Hws
involves: BALB/c 		abnormal immunoglobulin level J:142069
decreased B cell number J:142069
decreased bone marrow cell number J:142069
decreased follicular B cell number J:142069
decreased IgG1 level J:142069
decreased IgG2a level J:142069
decreased IgG2b level J:142069
decreased IgM level J:142069
decreased immature B cell number J:142069
decreased late pro-B cell number J:142069
decreased mature B cell number J:142069
decreased transitional stage B cell number J:142069
increased IgM level J:142069
spleen hypoplasia J:142069
Ightm3Mnz/Ightm4.1Mnz
involves: C57BL/6 		normal immune system phenotype J:159173
Ightm4.1Cog/Ightm4.1Cog
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal class switch recombination J:184094
decreased IgA level J:184094
normal immune system phenotype J:184094
increased IgM level J:184094
Ightm4.1Fwa/Igh+
involves: 129S6/SvEvTac 		abnormal B cell differentiation J:176649
abnormal immunoglobulin V(D)J recombination J:176649
Ightm4.1Fwa/Ightm4.1Fwa
involves: 129S6/SvEvTac 		abnormal B cell differentiation J:176649
abnormal immunoglobulin V(D)J recombination J:176649
Ightm4Cgn/Igh+
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:115292
Ightm5.1Cgn/Ightm5.1Cgn
BALB/c-Ightm5.1Cgn 		abnormal B cell activation J:88472
abnormal B cell differentiation J:88472
abnormal gut-associated lymphoid tissue morphology J:88472
abnormal lymph node germinal center morphology J:88472
abnormal mature B cell morphology J:88472
abnormal Peyer's patch germinal center morphology J:88472
absent B-1 B cells J:88472
absent B-1a cells J:88472
absent B-1b cells J:88472
absent spleen germinal center J:88472
decreased B cell number J:88472
decreased immature B cell number J:88472
decreased marginal zone B cell number J:88472
increased pro-B cell number J:88472
Ightm5.1Cog/Ightm5.1Cog
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:164513
abnormal somatic hypermutation frequency J:164513, J:333348
decreased IgA level J:164513
decreased IgE level J:164513
decreased IgG2b level J:164513
decreased IgG3 level J:164513
decreased IgM level J:164513
Ightm5.1Fwa/Igh+
involves: 129S6/SvEvTac 		abnormal B cell differentiation J:176649
decreased pre-B cell number J:176649
normal immune system phenotype J:176649
Ightm5.1Fwa/Ightm5.1Fwa
involves: 129S6/SvEvTac 		abnormal B cell differentiation J:176649
decreased pre-B cell number J:176649
normal immune system phenotype J:176649
Ightm5Cgn/Ightm5Cgn
involves: BALB/c 		absent B cells J:88472
arrested B cell differentiation J:88472
Ightm5Cgn/Ightm5Cgn
Tg(CD19-cre/ERT2)1Cgn/0
C.Cg-Ightm5Cgn Tg(CD19-cre/ERT2)1Cgn 		abnormal B cell differentiation J:88472
abnormal mature B cell morphology J:88472
abnormal Peyer's patch germinal center morphology J:88472
absent follicular B cells J:88472
absent marginal zone B cells J:88472
increased B cell number J:88472
increased pro-B cell number J:88472
Ightm6Fwa/Ightm6Fwa
Not Specified 		normal immune system phenotype J:176649
Ightm7(VHB1-8)Cgn/Igh+
involves: 129P2/OlaHsd * C57BL/6 		abnormal somatic hypermutation frequency J:48835
Ightm7.1Fwa/Ightm7.1Fwa
Not Specified 		normal immune system phenotype J:176649
Ightm8(VHB1-8)Cgn/Igh+
involves: 129P2/OlaHsd * C57BL/6 		abnormal somatic hypermutation frequency J:48835
Ightm9(VHB1-8)Cgn/Igh+
involves: 129P2/OlaHsd * C57BL/6 		abnormal somatic hypermutation frequency J:48835
Ightm11.1Cgn/Ightm11.1Cgn
Not Specified 		abnormal B cell differentiation J:113434
decreased B cell number J:113434
decreased immature B cell number J:113434
decreased mature B cell number J:113434
increased pro-B cell number J:113434
Ightm12Cgn/Ightm12Cgn
involves: 129P2/OlaHsd 		abnormal somatic hypermutation frequency J:66031
Tg(Igh3H9)41Mwg/?
involves: C57BL/6 * SJL 		abnormal B cell differentiation J:119625
decreased IgD level J:119625
increased anti-single stranded DNA antibody level J:119625
Tg(Igh-3VD93)343Ust/?
involves: C57BL/6 * SJL 		abnormal B cell morphology J:135209
decreased pre-B cell number J:135209
Tg(IghH280)48Dvs/?
NOD/ShiLtDvs-Tg(IghH280)48Dvs/J 		increased susceptibility to autoimmune diabetes J:274578
insulitis J:274578
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory