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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ighm
immunoglobulin heavy constant mu
MGI:96448
65 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aicdatm1Hon/Aicdatm1Hon
Ighmtm1.1(IGH-2)Cog/Ighm+
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N 		abnormal B cell physiology J:157575
Atmintm1.1Jhh/Atmintm1.1Jhh
Ighmtm1(Bcl6)Rdf/Ighm+
Tg(Fcer2a-cre)5Mbu/0
B6.Cg-Atmintm1.1Jhh Ighmtm1(Bcl6)Rdf Tg(Fcer2a-cre)5Mbu 		abnormal tumor susceptibility J:230105
Atp11cm1Btlr/Y
Tg(IghmHyHEL10,IgkHyHEL10)4Ccg/0
involves: C57BL/6 * C57BL/6J * C57BL/6JSfdAnu 		decreased B cell number J:171925
Bcl6tm2Rdf/Bcl6tm2Rdf
Ighmtm1(Bcl6)Rdf/?
involves: 129/Sv * 129S1/Sv * C57BL/6 		abnormal immune system morphology J:98937
abnormal spleen germinal center morphology J:98937
Faslpr/Faslpr
Ighmtm1Cgn/Ighmtm1Cgn
involves: 129S2/SvPas * C57BL/6 * MRL/Mp 		abnormal humoral immune response J:119584
abnormal immunoglobulin level J:119584
arrested B cell differentiation J:119584
decreased IgM level J:119584
decreased mature B cell number J:119584
enlarged lymph nodes J:119584
increased autoantibody level J:119584
increased T cell number J:119584
increased urine protein level J:119584
Faslgld/Faslgld
Ighmtm1Cgn/Ighmtm1Cgn
involves: 129S2/SvPas * C3H/HeJ * C57BL/6 		normal immune system phenotype J:119584
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Ighmtm1Cgn/Ighmtm1Cgn
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-Ighmtm1Cgn H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell 		abnormal PR interval J:113267
enlarged heart J:113267
heart inflammation J:113267
Ighmtm1(Bcl6)Rdf/?
involves: 129/Sv * C57BL/6 		abnormal B cell proliferation J:98937
abnormal spleen B cell follicle morphology J:98937
abnormal spleen morphology J:98937
decreased immunoglobulin level J:98937
decreased plasma cell number J:98937
enlarged spleen J:98937
increased B cell derived lymphoma incidence J:98937
increased spleen germinal center number J:98937
increased spleen white pulp amount J:98937
premature death J:98937
Ighmtm1Cgn/Ighm+
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * C57BL/6 * CF-1 		increased cell proliferation J:99033
thymus hypoplasia J:99033
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt 		insulitis J:91865
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		increased circulating glucose level J:91865
increased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
Ighmtm1Cgn/Ightm3Tim
involves: 129 * C57BL/6 		abnormal B cell differentiation J:102308
decreased B cell number J:102308
Ighmtm1Cgn/Ighmtm1Cgn
Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn
involves: 129 		decreased IgG level J:130864
decreased IgM level J:130864
Ighmtm1Cgn/Ighmtm1Cgn
Irf2tm1Mak/Irf2tm1Mak
involves: 129S2/SvPas * C57BL/6 		abnormal skin condition J:66034
Ighmtm1Cgn/Ighmtm1Cgn
Nlrp1aNeut1/Nlrp1aNeut1
involves: 129S2/SvPas * C57BL/6 		normal immune system phenotype J:191055
Ighmtm1Cgn/Ighmtm1Cgn
Ptpn6me-v/Ptpn6me-v
involves: 129S7/SvEvBrd * C57BL/6J 		decreased retina photoreceptor cell number J:108375
retina photoreceptor degeneration J:108375
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		insulitis J:91865
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt 		insulitis J:91865
Ighmtm1Cgn/Ighmtm1Cgn
Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ 		abnormal B lymphocyte antigen presentation J:80859
abnormal mature B cell morphology J:80859
abnormal T cell proliferation J:80859
decreased CD8-positive, alpha-beta T cell number J:80859
decreased susceptibility to autoimmune diabetes J:80859
increased lymphoma incidence J:80859
insulitis J:80859
Ighmtm1Cgn/Ighmtm1Cgn
Tg(IghMyc)22Bri/0
involves: 129S2/SvPas * C57BL * SJL 		increased lymphoma incidence J:187318
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Ins2-Cxcl13)1Cys/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal pancreatic islet morphology J:110548
Ighmtm1Cgn/Ighmtm1Cgn
Tg(TcraR28,TcrbR28)KRNDim/0
involves: 129S2/SvPas * C57BL/6 * NOD * SJL 		normal immune system phenotype J:36815
Ighmtm1Cgn/Ighmtm1Cgn
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * C57BL/6 * CF-1 		abnormal inflammatory response J:99033
cachexia J:99033
premature death J:99033
thymus hypoplasia J:99033
Ighmtm1Cgn/Ighmtm1Cgn
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J 		small intestinal inflammation J:108572
Ighmtm1Cgn/Ighmtm1Cgn
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		cardiac fibrosis J:181257
increased inflammatory response J:181257
kidney inflammation J:181257
myocarditis J:181257
premature death J:181257
normal renal/urinary system phenotype J:181257
tubular nephritis J:181257
Ighmtm1Cgn/Ighmtm1Cgn
Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		normal hematopoietic system phenotype J:174308
normal mortality/aging J:174308
thrombocytopenia J:174308
Ighmtm1Cgn/Ighmtm1Cgn
X/Yaa
BXSB.129S2(B6)-Ighmtm1Cgn/Dcr 		decreased susceptibility to systemic lupus erythematosus J:206236
Ighmtm1Msn/Ighmtm1Msn
Tg(Igh-6)1Msn/?
B6.129S-Ighmtm1Msn 		abnormal B-1a B cell morphology J:80656
abnormal splenic cell ratio J:80656
decreased follicular B cell number J:80656
decreased IgM level J:80656
increased marginal zone B cell number J:80656
Ighmtm3Bgmn/Ighmtm3Bgmn
Igkctm1Bgmn/Igkctm1Bgmn
Igltm2.1Bgmn/Igltm2.1Bgmn
involves: 129P2/OlaHsd * 129/Sv 		abnormal B cell differentiation J:130864
decreased IgG level J:130864
decreased IgM level J:130864
Tg(Igh-3/Igh-6VD93)1241Ust/?
C57BL/6-Tg(Igh-3/Igh-6VD93)1241Ust 		abnormal B cell morphology J:135209
decreased pre-B cell number J:135209
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt 		abnormal B cell number J:91865
increased circulating glucose level J:91865
increased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.B6-Tg(Igh-6/Igh-V281)3Jwt 		decreased susceptibility to autoimmune diabetes J:91865
insulitis J:91865
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory