Igh-8 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Igh-8
immunoglobulin heavy chain 8 (heavy chain of IgG3)
MGI:96450

6 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Igh-8^tm1.1Aak/Igh-8^tm1.1Aak involves: 129S2/SvPas * C57BL/6	abnormal class switch recombination	J:171251
Igh-8^tm1Aak/Igh-8^tm1Aak involves: 129S2/SvPas * C57BL/6	abnormal class switch recombination	J:107063
Igh-8^tm1Schr/Igh-8^tm1Schr C.129P2(BKSW)-Igh-8^tm1Schr	increased IgG level	J:75577
	increased IgM level	J:75577
	increased susceptibility to bacterial infection	J:75577
Igh-8^tm1Schr/Igh-8^tm1Schr involves: 129P2/OlaHsd * Black Swiss	increased IgM level	J:49847
Igh-8^{tm2(Ighg1)Aak}/Igh-8^{tm2(Ighg1)Aak} involves: 129S2/SvPas	abnormal class switch recombination	J:130574
	decreased IgG3 level	J:130574
Igh-8^tm2.1Aak/Igh-8^tm2.1Aak involves: 129S2/SvPas * C57BL/6	normal immune system phenotype	J:171251

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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