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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rbpj
recombination signal binding protein for immunoglobulin kappa J region
MGI:96522
122 phenotypes from 6 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Rbpjtm1Hon/Rbpjtm1Hon
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:76240
decreased marginal zone B cell number J:76240, J:121523
increased follicular B cell number J:76240, J:121523
increased IgG3 level J:76240
increased susceptibility to bacterial infection J:76240
increased susceptibility to bacterial infection induced morbidity/mortality J:76240
Pax3tm1(cre)Joe/Pax3+
Rbpjtm1Hon/Rbpjtm1Hon
involves: 129P2/OlaHsd 		abnormal diaphragm morphology J:120053
abnormal dorsal interneuron 4 morphology J:130251
abnormal epaxial muscle morphology J:120053
abnormal glutaminergic neuron morphology J:130251
abnormal intercostal muscle morphology J:120053
abnormal myogenesis J:120053
abnormal neural tube morphology J:130251
abnormal neuron differentiation J:130251
decreased neuronal precursor cell number J:130251
decreased satellite cell number J:120053
hypaxial muscle hypoplasia J:120053
loss of GABAergic neurons J:130251
neonatal lethality, complete penetrance J:120053
no spontaneous movement J:120053
respiratory failure J:120053
Pgrtm2(cre)Lyd/Pgr+
Rbpjtm1Hon/Rbpjtm1Hon
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal decidualization J:326956
Ptf1atm1(cre)Hnak/Ptf1a+
Rbpjtm1Rsch/Rbpjtm1Rsch
involves: 129X1/SvJ 		abnormal digestion J:139250
abnormal pancreas development J:139250
abnormal pancreas morphology J:139250
abnormal pancreatic alpha cell differentiation J:139250
decreased pancreatic acinar cell number J:139250
decreased pancreatic islet number J:139250
disorganized pancreatic islets J:139250
increased pancreatic alpha cell number J:139250
postnatal growth retardation J:139250
postnatal lethality, complete penetrance J:139250
small pancreas J:139250
Rbpjtm1.1Hon/Rbpj+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal retina vasculature morphology J:254752
Rbpjtm1.1Rsch/Rbpjtm1.1Rsch
involves: 129X1/SvJ 		prenatal lethality, complete penetrance J:139250
Rbpjtm1b(EUCOMM)Hmgu/Rbpj+
C57BL/6N-Rbpjtm1b(EUCOMM)Hmgu/J 		decreased bone mineral density J:211773
decreased circulating HDL cholesterol level J:211773
improved glucose tolerance J:211773
increased circulating bilirubin level J:211773
increased grip strength J:211773
Rbpjtm1b(EUCOMM)Hmgu/Rbpjtm1b(EUCOMM)Hmgu
C57BL/6N-Rbpjtm1b(EUCOMM)Hmgu/J 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Rbpjtm1Hon/Rbpj+
Tg(Tyr-cre)2Lru/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		normal pigmentation phenotype J:116658
Rbpjtm1Hon/Rbpjtm1.1Hon
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal respiratory epithelium morphology J:150051
absent club cells J:150051
Rbpjtm1Hon/Rbpjtm1.1Hon
Tg(Pax7-cre/ERT2)1Cbm/0
involves: 129P2/OlaHsd * BALB/cJ 		abnormal glutaminergic neuron morphology J:130251
abnormal neural tube morphology J:130251
abnormal neuron differentiation J:130251
decreased neuronal precursor cell number J:130251
loss of GABAergic neurons J:130251
Rbpjtm1Hon/Rbpjtm1Hon
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:76240
Rbpjtm1Hon/Rbpjtm1Hon
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca 		decreased tumor growth/size J:162770
Rbpjtm1Hon/Rbpjtm1Hon
Mesp1tm2(cre)Ysa/Mesp1+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal atrioventricular cushion morphology J:139209
abnormal cardiac epithelial to mesenchymal transition J:139209
abnormal heart development J:139209
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal T-helper 2 cell differentiation J:90018
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Col1a1-cre)1Kry/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		normal skeleton phenotype J:233131
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Cyp1a1-cre)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal crypts of Lieberkuhn morphology J:99348
abnormal intestinal epithelium morphology J:99348
abnormal intestinal goblet cell morphology J:99348
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cytokine secretion J:125869
decreased dendritic cell number J:125869
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Lbx1-cre)3Cbm/0
involves: 129P2/OlaHsd 		abnormal myogenesis J:120053
abnormal suckling behavior J:120053
decreased satellite cell number J:120053
decreased skeletal muscle fiber density J:120053
hypaxial muscle hypoplasia J:120053
neonatal lethality, complete penetrance J:120053
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Lck-cre)19Hhan/0
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal CD4-positive helper T cell morphology J:168475
abnormal immune system physiology J:168475
abnormal regulatory T cell physiology J:168475
normal immune system phenotype J:168475
increased macrophage cell number J:168475
increased single-positive T cell number J:168475
increased splenocyte number J:168475
increased T cell number J:168475
increased T cell proliferation J:168475
Rbpjtm1Hon/Rbpjtm1Hon
Tg(MMTV-cre)1Mam/0
involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL 		abnormal mammary gland growth during pregnancy J:108712
epidermal cyst J:108712
hyperkeratosis J:108712
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal B cell differentiation J:99747
abnormal lymphopoiesis J:99747
arrested T cell differentiation J:99747, J:125869
decreased dendritic cell number J:125869
decreased double-positive T cell number J:99747
decreased follicular dendritic cell number J:125869
decreased marginal zone B cell number J:76240, J:99747
decreased single-positive T cell number J:99747
decreased thymocyte number J:99747
increased B cell number J:99747, J:125869
increased double-negative T cell number J:99747
increased follicular B cell number J:99747
increased macrophage cell number J:125869
increased monocyte cell number J:125869
increased plasmacytoid dendritic cell number J:125869
small thymus J:99747
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Nes-cre)1Wme/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cell differentiation J:82337
epidermal cyst J:82337
hyperkeratosis J:82337
loss of vibrissae J:82337
premature hair loss J:82337
thick epidermis J:82337
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Pax2-cre)1Akg/0
involves: 129P2/OlaHsd 		abnormal proximal convoluted tubule morphology J:119907
absent podocytes J:119907
embryonic lethality during organogenesis, complete penetrance J:119907
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Tek-cre)1Ywa/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		embryonic lethality, incomplete penetrance J:158959
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Tyr-cre)2Lru/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		diluted coat color J:116658
normal pigmentation phenotype J:116658
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Tyr-cre)#Lru/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal hair follicle melanocyte morphology J:111228
abnormal hair follicle melanogenesis J:111228
abnormal melanoblast morphology J:111228
absent coat pigmentation J:111228
decreased melanocyte number J:111228
diluted coat color J:111228
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal crypts of Lieberkuhn morphology J:99348
Rbpjtm1Kyo/Rbpj+
involves: 129S2/SvPas * CD-1 		abnormal aortic valve morphology J:187551
abnormal heart echocardiography feature J:187551
aortic valve inflammation J:187551
calcified aortic valve cusp J:187551
cardiac fibrosis J:187551
decreased cardiac muscle contractility J:187551
thick aortic valve cusps J:187551
Rbpjtm1Kyo/Rbpjtm1Hon
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal anterior cardinal vein morphology J:93125
abnormal common cardinal vein morphology J:93125
abnormal dorsal aorta morphology J:93125
abnormal vascular regression J:93125
absent vitelline blood vessels J:93125
arteriovenous malformation J:93125
embryonic growth retardation J:93125
pericardial effusion J:93125
Rbpjtm1Kyo/Rbpjtm1Kyo
involves: 129S2/SvPas 		abnormal fetal cardiomyocyte proliferation J:119151
abnormal humoral immune response J:123631
abnormal myocardium layer morphology J:119151
abnormal response to infection J:123631
decreased interleukin-4 secretion J:123631
disorganized myocardium J:119151
trabecula carnea hypoplasia J:119151
Rbpjtm1Kyo/Rbpjtm1Kyo
involves: 129S2/SvPas * C57BL/6 		abnormal anterior cardinal vein morphology J:93125
abnormal blood vessel morphology J:93125
abnormal common cardinal vein morphology J:93125
abnormal dorsal aorta morphology J:93125
abnormal placental labyrinth vasculature morphology J:93125
abnormal vascular regression J:93125
abnormal vitelline vascular remodeling J:93125
arteriovenous malformation J:93125
decreased spongiotrophoblast size J:93125
embryonic growth retardation J:93125
embryonic lethality between somite formation and embryo turning, complete penetrance J:57072
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory