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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
MGI:96534
37 phenotypes from 6 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74/MOG)Awai/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:140751
decreased susceptibility to experimental autoimmune encephalomyelitis J:140751
Cd74em1(IMPC)H/Cd74em1(IMPC)H
C57BL/6N-Cd74em1(IMPC)H/H 		decreased lymphocyte cell number J:211773
increased eosinophil cell number J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
Cd74tm1Doi/Cd74tm1Doi
either: (involves: 129/Sv * B10.BR) or (involves: 129/Sv * C57BL/6) 		abnormal antigen presentation J:4119
abnormal level of surface class II molecules J:45185
decreased CD4-positive, alpha-beta T cell number J:4119, J:45185
increased CD8-positive, alpha-beta T cell number J:4119
Cd74tm1Doi/Cd74tm1Doi
involves: 129S2/SvPas 		abnormal dendritic cell antigen presentation J:151699
Cd74tm1Eae/Cd74tm1Eae
B6.129S2-Cd74tm1Eae 		abnormal lymph node cell ratio J:112084
arrested B cell differentiation J:112084
Cd74tm1Eae/Cd74tm1Eae
involves: 129S2/SvPas 		abnormal level of surface class II molecules J:65917
decreased B cell proliferation J:113050, J:132865
decreased CD4-positive, alpha-beta T cell number J:113050
decreased cell proliferation J:147772
decreased IgM level J:113050
Cd74tm1Eae/Cd74tm1Eae
involves: 129S2/SvPas * C57BL/6 		increased myocardial infarct size J:213776
increased susceptibility to myocardial ischemic injury J:213776
Cd74tm1Liz/Cd74+
involves: 129S/SvEv 		normal hematopoietic system phenotype J:155870
Cd74tm1Liz/Cd74tm1Liz
B6.129S-Cd74tm1Liz 		abnormal antigen presentation J:125654
abnormal antigen presentation via MHC class II J:28966
abnormal level of surface class II molecules J:28966
abnormal T-helper 1 physiology J:125654
decreased CD4-positive, alpha-beta T cell number J:28966
decreased susceptibility to experimental autoimmune encephalomyelitis J:125654
decreased susceptibility to type IV hypersensitivity reaction J:125654
decreased T cell proliferation J:28966
defective assembly of class II molecules J:28966
Cd74tm1Liz/Cd74tm1Liz
B6.129S-Cd74tm1Liz/J 		decreased B cell number J:194664
Cd74tm1Liz/Cd74tm1Liz
involves: 129S/SvEv 		abnormal positive T cell selection J:125548
normal hematopoietic system phenotype J:155870
Cd74tm1Liz/Cd74tm1Liz
involves: 129S/SvEv * BALB/c * C57BL 		abnormal antigen presentation via MHC class II J:110927
abnormal B cell differentiation J:110927
abnormal dendritic cell antigen presentation J:110927
abnormal T cell proliferation J:110927
increased immature B cell number J:110927
Cd74tm1Liz/Cd74tm1Liz
involves: 129S/SvEv * BALB/cAn 		abnormal antigen presentation via MHC class II J:110927, J:113714
abnormal B cell differentiation J:110927
abnormal dendritic cell antigen presentation J:110927
abnormal professional antigen presenting cell physiology J:113714
decreased CD4-positive, alpha-beta T cell number J:110927, J:113714
increased immature B cell number J:110927
Cd74tm1Liz/Cd74tm1Liz
involves: 129S/SvEv * C57BL * C57BL/10 * C57BR 		abnormal antigen presentation via MHC class II J:110927
abnormal B cell differentiation J:110927
abnormal dendritic cell antigen presentation J:110927
abnormal T cell proliferation J:110927
increased immature B cell number J:110927
Cd74tm1Liz/Cd74tm1Liz
involves: 129S/SvEv * C57BL/6 		abnormal antigen presentation via MHC class II J:111565
Cd74tm1Liz/Cd74tm1Liz
involves: 129S/SvEv * C57BL/6J 		abnormal antigen presentation J:72243
abnormal antigen presentation via MHC class II J:65918
abnormal level of surface class II molecules J:65918
cachexia J:65918
decreased body size J:65918
decreased CD4-positive, alpha-beta T cell number J:65918
decreased interferon-gamma secretion J:72243
decreased susceptibility to experimental autoimmune encephalomyelitis J:72243
decreased T cell proliferation J:72243
defective assembly of class II molecules J:65918
Cd74tm2Liz/Cd74tm1Liz
involves: 129S/SvEv * C57BL/6 		abnormal antigen presentation via MHC class II J:28966
normal immune system phenotype J:28966
increased T cell proliferation J:28966
Cd74tm2Liz/Cd74tm2Liz
involves: 129S/SvEv * C57BL/6 		decreased interleukin-2 secretion J:72243
increased susceptibility to experimental autoimmune encephalomyelitis J:72243
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory