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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il10
interleukin 10
MGI:96537
63 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Unc/Apoetm1Unc
Il10tm1Cgn/Il10tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal arterial thrombosis J:105858
abnormal blood coagulation J:105858
abnormal circulating cholesterol level J:105858
abnormal circulating cytokine level J:105858
decreased circulating VLDL cholesterol level J:105858
increased circulating interferon-gamma level J:105858
increased circulating interleukin-12 level J:105858
increased circulating LDL cholesterol level J:105858
increased susceptibility to atherosclerosis J:105858
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74/MOG)Awai/Gt(ROSA)26Sor+
Il10tm1Roer/Il10tm1Roer
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:140751
decreased susceptibility to experimental autoimmune encephalomyelitis J:140751
Cd44tm1.1Ugu/Cd44tm1.1Ugu
Il10tm1Cgn/Il10tm1Cgn
involves: 129/Sv * C57BL/6 		abnormal immune system physiology J:62867
weight loss J:62867
Faslpr/Faslpr
Tg(INS-Il10)#Sar/0
NOD.Cg-Faslpr Tg(INS-Il10)#Sar 		increased susceptibility to autoimmune diabetes J:64051
insulitis J:64051
Icam1tm1Jcgr/Icam1tm1Jcgr
Tg(INS-Il10)#Sar/0
NOD.Cg-Icam1tm1Jcgr Tg(INS-Il10)#Sar 		decreased susceptibility to autoimmune diabetes J:66103
periinsulitis J:66103
Il10tm1Cgn/Il10tm1Cgn
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 1 cell differentiation J:111712
increased interferon-gamma secretion J:111712
Il10tm1Cgn/Il10tm1Cgn
Il12btm1Jm/Il12btm1Jm
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal T-helper 2 cell differentiation J:111712
increased interleukin-13 secretion J:111712
Il10tm1Cgn/Il10tm1Cgn
Il27ratm1Mak/Il27ratm1Mak
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 1 physiology J:136179
abnormal T-helper 2 physiology J:136179
colitis J:136179
decreased interferon-gamma secretion J:136179
decreased susceptibility to induced colitis J:136179
extended life span J:136179
increased interleukin-13 secretion J:136179
Il10tm1Cgn/Il10tm1Cgn
Nfil3tm1Look/Nfil3tm1Look
involves: 129P2/OlaHsd * 129X1/SvJ 		colitis J:209365
increased interleukin-12 secretion J:209365
Il10tm1Cgn/Il10tm1Cgn
Nfil3tm1Pbro/Nfil3tm1Pbro
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		colitis J:209365
decreased colon length J:209365
diarrhea J:209365
increased interleukin-12 secretion J:209365
rectal prolapse J:209365
Il10tm1Cgn/Il10tm1Cgn
Nos2tm1Lau/Nos2tm1Lau
involves: 129P2/OlaHsd * C57BL/6 		increased myocardial infarct size J:70292
Il10tm1Cgn/Il10tm1Cgn
Rps6ka4tm1Jsca/Rps6ka4tm1Jsca
Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca 		decreased interleukin-10 secretion J:139576
increased interleukin-6 secretion J:139576
increased interleukin-12a secretion J:139576
increased interleukin-12b secretion J:139576
increased tumor necrosis factor secretion J:139576
Il10tm1Cgn/Il10tm1Cgn
Rreb1Sao/Rreb1Sao
NOD.Cg-Il10tm1Cgn Rreb1Sao 		ataxia J:237902
decreased Purkinje cell number J:237902
rectal prolapse J:237902
tremors J:237902
Il10tm1Cgn/Il10tm1Cgn
Tg(MUC1)79.24Gend/0
B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend 		increased colon adenocarcinoma incidence J:149347
large intestinal inflammation J:149347
rectal prolapse J:149347
Il10tm1Cgn/Il10tm1Cgn
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL 		abnormal gut flora balance J:229155
colitis J:229155
premature death J:229155
rectal prolapse J:229155
Il10tm1Cgn/Il10tm1Cgn
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac 		colitis J:229155
premature death J:229155
rectal prolapse J:229155
Il10tm1Cgn/Il10tm1Cgn
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:107077
abnormal cytokine level J:107077
abnormal lymph node cell ratio J:107077
abnormal splenic cell ratio J:107077
abnormal thymus corticomedullary boundary morphology J:107077
abnormal thymus involution J:107077
absent spleen white pulp J:107077
anemia J:107077
colitis J:107077
decreased lymphocyte cell number J:107077
decreased T cell proliferation J:107077
enlarged mesenteric lymph nodes J:107077
enlarged spleen J:107077
increased macrophage cell number J:107077
increased neutrophil cell number J:107077
increased spleen red pulp amount J:107077
increased T cell apoptosis J:107077
intestinal inflammation J:107077
rectal prolapse J:107077
thymus hypoplasia J:107077
Il10tm1Keny/Il10+
Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
involves: 129 * C57BL/6 		decreased interleukin-10 secretion J:172134
Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0
involves: 129S7/SvEvBrd * BALB/c * NOD 		decreased susceptibility to autoimmune diabetes J:64051
Prkdcscid/Prkdcscid
Tg(INS-Il10)#Sar/0
NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar 		increased susceptibility to autoimmune diabetes J:66103
Tg(INS-Il10)#Sar/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6J * NOD 		increased circulating glucose level J:64051
increased susceptibility to autoimmune diabetes J:64051
Tg(INS-Il10)#Sar/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6J * NOD 		increased circulating glucose level J:64051
increased susceptibility to autoimmune diabetes J:64051
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory