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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il10ra
interleukin 10 receptor, alpha
MGI:96538
29 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Il10ratm1.1Jack/Il10ratm1.1Jack
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		normal immune system phenotype J:157787
Il10ram1Jskg/Il10ram1Jskg
B6.Cg-Il10ram1Jskg 		colitis J:146644
Il10raNZW/Il10ra+
(NZB x NZW)F1 		increased anti-chromatin antibody level J:102087
increased IgG level J:102087
Il10ratm1.1Jack/Il10ratm1.1Jack
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal chemokine level J:157787
abnormal cytokine level J:157787
increased circulating interferon-gamma level J:157787
increased circulating interleukin-1 alpha level J:157787
increased circulating interleukin-1 beta level J:157787
increased circulating interleukin-2 level J:157787
increased circulating interleukin-12 level J:157787
increased circulating interleukin-17 level J:157787
increased circulating tumor necrosis factor level J:157787
increased susceptibility to parasitic infection J:157787
Il10ratm1.1Jack/Il10ratm1.1Jack
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2 		normal immune system phenotype J:157787
Il10ratm1.1Tlg/Il10ratm1.1Tlg
Tg(Cd4-cre)1Cwi/?
B6.Cg-Tg(Cd4-cre)1Cwi Il10ratm1.1Tlg 		abnormal lymphocyte cell number J:189797
abnormal regulatory T cell number J:189797
autoimmune response J:189797
decreased splenocyte proliferation J:189797
decreased T cell number J:189797
normal immune system phenotype J:189797
Il10ratm1.2Jack/Il10ratm1.2Jack
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2 		abnormal chemokine level J:157787
abnormal cytokine level J:157787
cecum inflammation J:157787
increased circulating interferon-gamma level J:157787
increased circulating interleukin-1 alpha level J:157787
increased circulating interleukin-1 beta level J:157787
increased circulating interleukin-2 level J:157787
increased circulating interleukin-6 level J:157787
increased circulating interleukin-12 level J:157787
increased circulating interleukin-17 level J:157787
increased circulating tumor necrosis factor level J:157787
increased susceptibility to induced colitis J:157787
increased susceptibility to parasitic infection J:157787
Il10ratm1b(KOMP)Wtsi/Il10ratm1b(KOMP)Wtsi
C57BL/6N-Il10ratm1b(KOMP)Wtsi/Orl 		abnormal auditory brainstem response J:211773
decreased blood urea nitrogen level J:211773
decreased lymphocyte cell number J:211773
decreased startle reflex J:211773
improved glucose tolerance J:211773
increased neutrophil cell number J:211773
Scn10atm2(cre)Jwo/Scn10a+
Il10ratm1.1Jack/Il10ratm1.1Jack
involves: 129P2/OlaHsd 		normal behavior/neurological phenotype J:326965
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory