Il12b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il12b
interleukin 12b
MGI:96540

19 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il12b^em1(IMPC)H/Il12b^em1(IMPC)H C57BL/6NTac-Il12b^em1(IMPC)H/H	impaired glucose tolerance	J:211773
Il12b^tm1Jm/Il12b^tm1Jm 129S1/Sv-Il12b^tm1Jm	abnormal CD4-positive, alpha-beta T cell physiology	J:34164
	decreased susceptibility to type IV hypersensitivity reaction	J:34164
	increased susceptibility to parasitic infection	J:34164
Il12b^tm1Jm/Il12b^tm1Jm B6.129S1-Il12b^tm1Jm/J	abnormal CD8-positive, alpha-beta T cell physiology	J:111568
	abnormal granulocyte physiology	J:111568
	abnormal lymphocyte physiology	J:120806
	abnormal macrophage physiology	J:111568
	abnormal NK cell physiology	J:120806
	alveolar process atrophy	J:147935
	decreased circulating interferon-gamma level	J:120806
	decreased incidence of tumors by chemical induction	J:111568
	decreased interleukin-17 secretion	J:111568
	decreased susceptibility to type IV hypersensitivity reaction	J:120806
	increased susceptibility to bacterial infection	J:120806
	increased susceptibility to xenobiotic induced morbidity/mortality	J:91927
Il12b^tm1Jm/Il12b^tm1Jm involves: 129S1/Sv	increased susceptibility to bacterial infection induced morbidity/mortality	J:161073
Il12b^tm1Jm/Il12b^tm1Jm involves: 129S1/SvImJ	abnormal T-helper 1 physiology	J:46514
	decreased interferon-gamma secretion	J:46514
	impaired natural killer cell mediated cytotoxicity	J:46514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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