Il1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il1b
interleukin 1 beta
MGI:96543

32 phenotypes from 3 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il1b^tm1Dch/Il1b^tm1Dch B6.129S2-Il1b^tm1Dch	abnormal tooth root resorption	J:101998
Il1b^tm1Dch/Il1b^tm1Dch involves: 129S2/SvPas	decreased interleukin-1 beta secretion	J:33465
	decreased susceptibility to type IV hypersensitivity reaction	J:33465
	normal immune system phenotype	J:189777
	increased susceptibility to bacterial infection	J:112400
Il1b^tm1Dch/Il1b^tm1Dch involves: 129S2/SvPas * C57BL/6	abnormal insulin-like growth factor I level	J:71534
	abnormal myelination	J:71534
	abnormal oligodendrocyte morphology	J:71534
Il1b^tm1Lvp/Il1b^tm1Lvp 129S7/SvEvBrd-Il1b^tm1Lvp	normal immune system phenotype	J:173245
Il1b^tm1Lvp/Il1b^tm1Lvp involves: 129S7/SvEvBrd	abnormal macrophage physiology	J:136368
	abnormal tumor vascularization	J:82394
	decreased interleukin-1 beta secretion	J:136368
	decreased metastatic potential	J:59893, J:82394
	decreased susceptibility to induced morbidity/mortality	J:59893, J:82394
	decreased susceptibility to injury	J:128238
	decreased susceptibility to Togaviridae infection	J:52841
	decreased susceptibility to Togaviridae infection induced morbidity/mortality	J:52841
	decreased susceptibility to viral infection	J:135243
	decreased tumor growth/size	J:59893, J:82394
	decreased tumor necrosis factor secretion	J:82394
	increased susceptibility to bacterial infection induced morbidity/mortality	J:136368
Il1b^tm1Lvp/Il1b^tm1Lvp involves: 129S7/SvEvBrd * C57BL/6	abnormal interleukin-6 secretion	J:27234
	abnormal lymphocyte physiology	J:67001
	decreased acute inflammation	J:27234
	decreased circulating interleukin-1 beta level	J:27234
	decreased inflammatory response	J:27234
	decreased interferon-gamma secretion	J:67001
	decreased interleukin-2 secretion	J:67001
	decreased interleukin-4 secretion	J:67001
	decreased susceptibility to experimental autoimmune myasthenia gravis	J:67001
	decreased susceptibility to induced morbidity/mortality	J:67001
	impaired febrile response	J:27234
Il1b^tm1Lvp/Il1b^tm1Lvp involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * RIIIS	abnormal blood-brain barrier function	J:105009
	decreased susceptibility to injury	J:105009
Il1b^tm1Yiw/Il1b^tm1Yiw involves: 129S1/Sv * 129X1/SvJ	abnormal vascular wound healing	J:107324
Il1b^tm1Yiw/Il1b^tm1Yiw involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased circulating corticosterone level	J:47429
	decreased circulating interleukin-1 beta level	J:47429
	impaired febrile response	J:47429

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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