Il1r1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il1r1
interleukin 1 receptor, type I
MGI:96545

78 phenotypes from 7 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il1r1^{em1(IMPC)Ccpcz}/Il1r1^{em1(IMPC)Ccpcz} C57BL/6NCrl-Il1r1^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal spleen morphology	J:211773
	cataract	J:211773
	enlarged heart	J:211773
	enlarged kidney	J:211773
	enlarged spleen	J:211773
	increased kidney weight	J:211773
Il1r1^em1Qizh/Il1r1^em1Qizh C57BL/6-Il1r1^em1Qizh	increased circulating interleukin-6 level	J:338375
	increased circulating tumor necrosis factor level	J:338375
	increased susceptibility to induced arthritis	J:338375
Il1r1^tm1.1Rbl/Il1r1^tm1.1Rbl B6.129(Cg)-Il1r1^tm1.1Rbl	no abnormal phenotype detected	J:101977
Il1r1^tm1.2Quan/Il1r1^tm1.2Quan involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:219864
Il1r1^tm1Imx/Il1r1^tm1Imx B6.129S7-Il1r1^tm1Imx	normal immune system phenotype	J:173245
Il1r1^tm1Imx/Il1r1^tm1Imx B6.129S7-Il1r1^tm1Imx/J	abnormal lean body mass	J:108634
	abnormal nervous system electrophysiology	J:145169
	abnormal vascular wound healing	J:107324
	decreased anxiety-related response	J:150445
	decreased circulating interleukin-6 level	J:125570
	decreased circulating interleukin-18 level	J:125570
	decreased interleukin-6 secretion	J:125570, J:148779
	decreased locomotor activity	J:108634
	decreased response to leptin	J:108634
	decreased transforming growth factor beta level	J:148779
	decreased tumor necrosis factor secretion	J:125570
	enhanced contextual conditioning behavior	J:150445
	enhanced wound healing	J:148779
	impaired glucose tolerance	J:108634
	increased abdominal fat pad weight	J:108634
	increased body length	J:108634
	increased body mass index	J:108634
	increased body weight	J:108634
	increased circulating insulin level	J:108634
	increased circulating insulin-like growth factor I level	J:108634
	increased circulating interleukin-1 beta level	J:125570
	increased circulating interleukin-18 level	J:125570
	increased circulating leptin level	J:108634
	increased gonadal fat pad weight	J:108634
	increased growth rate	J:108634
	increased inguinal fat pad weight	J:108634
	increased liver weight	J:108634
	increased mesenteric fat pad weight	J:108634
	increased percent body fat/body weight	J:108634
	increased respiratory quotient	J:108634
	increased retroperitoneal fat pad weight	J:108634
	increased susceptibility to age related obesity	J:108634
	increased susceptibility to bacterial infection	J:125570
	increased susceptibility to bacterial infection induced morbidity/mortality	J:125570
	increased susceptibility to induced arthritis	J:125570
	increased total body fat amount	J:108634
	insulin resistance	J:108634
	sepsis	J:125570
	weight loss	J:125570
Il1r1^tm1Imx/Il1r1^tm1Imx involves: 129 * C57BL/6	decreased circulating interleukin-6 level	J:43088
	dental pulp necrosis	J:58851
	increased bone resorption	J:58851
	increased susceptibility to bacterial infection	J:58851
	osteomyelitis	J:58851
Il1r1^tm1Imx/Il1r1^tm1Imx involves: 129S7/SvEvBrd	abnormal neutrophil physiology	J:113110
Il1r1^tm1Imx/Il1r1^tm1Imx involves: 129S7/SvEvBrd	delayed tooth eruption	J:103141
Il1r1^tm1Imx/Il1r1^tm1Imx involves: 129S7/SvEvBrd * C57BL/6	abnormal neutrophil physiology	J:112999
	abnormal response/metabolism to endogenous compounds	J:112148
	decreased blood urea nitrogen level	J:112999
	decreased circulating creatinine level	J:112999
	decreased susceptibility to experimental autoimmune uveoretinitis	J:115094
	decreased susceptibility to kidney reperfusion injury	J:112999
	increased body weight	J:112148
Il1r1^tm1Quan/Il1r1^tm1Quan involves: C57BL/6	abnormal inflammatory response	J:219864
Il1r1^tm1Quan/Il1r1^tm1Quan involves: C57BL/6	abnormal microglial cell activation	J:219864
Il1r1^tm1Quan/Il1r1^tm1Quan Lyz2^tm1(cre)Ifo/Lyz2^tm1(cre)Ifo involves: 129P2/OlaHsd * C57BL/6	abnormal inflammatory response	J:219864
	abnormal microglial cell activation	J:219864
Il1r1^tm1Quan/Il1r1^tm1Quan Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6	abnormal inflammatory response	J:219864
	abnormal microglial cell activation	J:219864
Il1r1^tm1Roml/Il1r1^tm1Roml C.Cg-Il1r1^tm1Roml	decreased eosinophil cell number	J:82863
	decreased immunoglobulin level	J:82863
	decreased T cell number	J:82863
	decreased T cell proliferation	J:82863
Il1r1^tm1Roml/Il1r1^tm1Roml involves: 129S1/Sv	decreased neutrophil cell number	J:193548
	decreased susceptibility to induced arthritis	J:120707
	normal homeostasis/metabolism phenotype	J:193548
	normal integument phenotype	J:126327
Il1r1^tm1Roml/Il1r1^tm1Roml involves: 129S1/Sv * BALB/c	decreased incidence of tumors by chemical induction	J:191239
Il1r1^tm1Roml/Il1r1^tm1Roml involves: 129S1/Sv * BALB/c	impaired neutrophil chemotaxis	J:124226
Il1r1^tm1Roml/Il1r1^tm1Roml involves: 129S1/Sv * C57BL/6	decreased circulating interleukin-6 level	J:42373
	decreased circulating serum amyloid protein level	J:42373
	decreased interleukin-6 secretion	J:42373
	decreased susceptibility to type IV hypersensitivity reaction	J:42373
	impaired febrile response	J:42373
	increased susceptibility to bacterial infection	J:42373
Il1r1^tm1Roml/Il1r1^tm1Roml NOD.Cg-Il1r1^tm1Roml	abnormal cell death	J:87251
Il1r1^tm1Roml/Il1r1^tm1Roml NOD.Cg-Il1r1^tm1Roml	decreased susceptibility to autoimmune diabetes	J:87251

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