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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il1r1
interleukin 1 receptor, type I
MGI:96545
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1+
involves: 129S2/SvPas * 129S7/SvEvBrd * NOD 		abnormal conjunctiva goblet cell morphology J:163691
abnormal cornea epithelium morphology J:163691
abnormal lacrimal gland morphology J:163691
abnormal ocular surface morphology J:163691
cornea opacity J:163691
dry eyes J:163691
keratoconjunctivitis J:163691
lacrimal gland inflammation J:163691
Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1tm1Imx
involves: 129S2/SvPas * 129S7/SvEvBrd * NOD 		abnormal conjunctiva goblet cell morphology J:163691
abnormal cornea epithelium morphology J:163691
cornea opacity J:163691
dry eyes J:163691
keratoconjunctivitis J:163691
lacrimal gland inflammation J:163691
Apoetm1Unc/Apoetm1Unc
Il1r1tm1Imx/Il1r1tm1Imx
B6.129-Il1r1tm1Imx Apoetm1Unc 		abnormal blood vessel physiology J:148173
decreased circulating interleukin-6 level J:148173
decreased susceptibility to atherosclerosis J:148173
decreased systemic arterial blood pressure J:148173
increased vasoconstriction J:148173
increased vasodilation J:148173
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Il1r1tm1Imx/Il1r1tm1Imx
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		decreased susceptibility to endotoxin shock J:43088
Il1r1tm1Imx/Il1r1tm1Imx
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S7/SvEvBrd * C57BL/6 		abnormal chemokine level J:126652
decreased interleukin-6 secretion J:115094
decreased susceptibility to experimental autoimmune uveoretinitis J:115094
dental pulp necrosis J:58851
impaired neutrophil recruitment J:126652
increased bone resorption J:58851
increased susceptibility to bacterial infection J:58851
interstitial pneumonia J:126652
lung inflammation J:126652
osteomyelitis J:58851
Il1r1tm1Imx/Il1r1tm1Imx
Vsig4tm1Gne/Vsig4tm1Gne
B6.Cg-Il1r1tm1Imx Vsig4tm1Gne 		decreased susceptibility to experimental autoimmune encephalomyelitis J:281762
decreased T helper 1 cell number J:281762
decreased T-helper 17 cell number J:281762
increased susceptibility to induced colitis J:281762
Il1r1tm1Roml/Il1r1tm1Roml
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		normal immune system phenotype J:172117
increased interleukin-1 beta secretion J:172117
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp1aNeut1/Nlrp1aNeut1
involves: 129S1/Sv * C57BL/6 		abnormal leukocyte cell number J:191055
abnormal leukopoiesis J:191055
decreased eosinophil cell number J:191055
decreased lymphocyte cell number J:191055
decreased monocyte cell number J:191055
normal immune system phenotype J:191055
increased susceptibility to Riboviria infection J:191055
increased susceptibility to xenobiotic induced morbidity/mortality J:191055
thrombocytopenia J:191055
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * C57BL/6 		normal mortality/aging J:150054
skin inflammation J:150054
Il1r1tm1Roml/Il1r1tm1Roml
Tg(KRT14-Il1f6)1Hblu/?
involves: 129S1/Sv * C57BL/6 * DBA/2 		abnormal skin morphology J:126327
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Il1r1tm1Imx/Il1r1tm1Imx
B6;129S-Tnfrsf1atm1Imx Il1r1tm1Imx/J 		abnormal brain wave pattern J:137505
abnormal circadian temperature homeostasis J:137505
abnormal sleep pattern J:137505
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory