Il1r2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il1r2
interleukin 1 receptor, type II
MGI:96546

17 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxp3^{tm9(EGFP/cre/ERT2)Ayr}/Foxp3⁺ Il1r2^tm1.1Mchc/Il1r2^tm1.1Mchc involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac	abnormal adaptive immunity	J:347877
	abnormal alpha-beta T cell number	J:347877
	increased CD4-positive, alpha-beta T cell number	J:347877
	increased IgG level	J:347877
	increased spleen germinal center size	J:347877
	increased T follicular helper cell number	J:347877
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Il1r2^tm1.1Mchc/Il1r2^tm1.1Mchc involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac	abnormal adaptive immunity	J:347877
	increased IgG level	J:347877
	increased spleen germinal center size	J:347877
	increased T follicular helper cell number	J:347877
Il1r2^{tm1.1(KOMP)Vlcg}/Il1r2^{tm1.1(KOMP)Vlcg} C57BL/6N-Il1r2^{tm1.1(KOMP)Vlcg}/Ucd	abnormal auditory brainstem response	J:211773
Il1r2^tm1.2Mchc/Il1r2^tm1.2Mchc involves: BALB/cJ * C57BL/6J * C57BL/6NTac	abnormal CD8-positive, alpha-beta T cell number	J:347877
	abnormal T cell physiology	J:347877
	increased CD4-positive, alpha-beta T cell number	J:347877
	increased circulating interleukin-1 alpha level	J:347877
	increased circulating interleukin-6 level	J:347877
	increased inflammatory response	J:347877
Il1r2^{tm1a(EUCOMM)Wtsi}/Il1r2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Il1r2^{tm1a(EUCOMM)Wtsi}/Wtsi	increased grip strength	J:211773
Il1r2^tm1Yiw/Il1r2^tm1Yiw B6.129P2-Il1r2^tm1Yiw	abnormal macrophage physiology	J:274653
	normal immune system phenotype	J:274653
	increased macrophage cytokine production	J:274653
	increased susceptibility to induced arthritis	J:274653

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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