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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il1rn
interleukin 1 receptor antagonist
MGI:96547
52 phenotypes from 6 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il1rntm1.1Cga/Il1rntm1.1Cga
Lyz2tm1(cre)Ifo/Lyz2+
D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo 		abnormal chemokine secretion J:162760
increased interferon-gamma secretion J:162760
increased interleukin-1 beta secretion J:162760
increased interleukin-6 secretion J:162760
increased interleukin-17 secretion J:162760
increased susceptibility to induced arthritis J:162760
increased T cell proliferation J:162760
Il1rntm1Dih/Il1rn+
involves: 129S/SvEv * C57BL/6J 		decreased body weight J:36387
decreased susceptibility to bacterial infection J:36387
increased susceptibility to endotoxin shock J:36387
Il1rntm1Dih/Il1rntm1Dih
B6.129S-Il1rntm1Dih 		decreased circulating cholesterol level J:76336
Il1rntm1Dih/Il1rntm1Dih
involves: 129S/SvEv * C57BL/6J 		decreased body weight J:36387
decreased circulating cholesterol level J:76336
decreased circulating interleukin-1 level J:36387
decreased susceptibility to bacterial infection J:36387
increased acute inflammation J:61600, J:88605
increased circulating interleukin-6 level J:61600
increased circulating serum amyloid protein level J:61600
increased susceptibility to endotoxin shock J:36387
reduced fertility J:61600
Il1rntm1Nick/Il1rn+
involves: 129P2/OlaHsd * MF1 		aortitis J:59410
Il1rntm1Nick/Il1rntm1Nick
involves: 129P2/OlaHsd * MF1 		aneurysm J:59410
aortitis J:59410
artery stenosis J:59410
chronic inflammation J:59410
premature death J:59410
Il1rntm1Nick/Il1rntm1Nick
involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd 		aortitis J:89034
normal immune system phenotype J:89034
skin inflammation J:89034
Il1rntm1Nick/Il1rntm1Nick
involves: BALB/cAnNHsd 		abnormal dermal layer morphology J:89034
abnormal epidermal layer morphology J:89034
abnormal keratinocyte physiology J:89034
aortitis J:89034
epidermal desquamation J:89034
parakeratosis J:89034
pathological neovascularization J:89034
psoriasis J:89034
rheumatoid arthritis J:89034
skin inflammation J:89034
skin lesions J:89034
thick dermal layer J:89034
thick epidermis J:89034
Il1rntm1Nick/Il1rntm1Nick
involves: BALB/cAnNHsd * C57BL/6 		aortitis J:89034
normal immune system phenotype J:89034
rheumatoid arthritis J:89034
Il1rntm1Nick/Il1rntm1Nick
involves: C57BL/6 		normal immune system phenotype J:89034
Il1rntm1Sush/Il1rntm1Sush
involves: 129P2/OlaHsd * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:97684
abnormal dendritic cell differentiation J:97684
abnormal dendritic cell number J:97684
abnormal immune system organ morphology J:97684
abnormal T-helper 1 cell morphology J:97684
abnormal T-helper 2 cell morphology J:97684
granulomatous inflammation J:97684
Il1rntm1Yiw/Il1rntm1Yiw
B6.129-Il1rntm1Yiw 		abnormal vascular wound healing J:103068
decreased body weight J:103068
Il1rntm1Yiw/Il1rntm1Yiw
C.129-Il1rntm1Yiw 		increased interleukin-17 secretion J:143719
rheumatoid arthritis J:143719
Il1rntm1Yiw/Il1rntm1Yiw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal body temperature homeostasis J:47429
postnatal growth retardation J:47429
Tg(Il1rn)1Dih/0
involves: C57BL/6 * CBA 		abnormal angiogenesis J:88605
decreased circulating interleukin-6 level J:88605
decreased circulating serum amyloid protein level J:61600
decreased inflammatory response J:88605
decreased susceptibility to endotoxin shock J:36387
decreased susceptibility to Herpesvirales infection J:88605
increased susceptibility to bacterial infection J:36387
Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
involves: C57BL/6 * CBA 		decreased susceptibility to endotoxin shock J:36387
increased circulating interleukin-1 level J:36387
increased susceptibility to bacterial infection J:36387
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory