Il2rb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il2rb
interleukin 2 receptor, beta chain
MGI:96550

53 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il2rb^m1Btlr/Il2rb^m1Btlr C57BL/6J-Il2rb^m1Btlr	decreased B cell number	J:267694
	decreased CD4-positive, alpha-beta T cell number	J:267694
	decreased CD8-positive, naive alpha-beta T cell number	J:267694
	increased effector memory CD4-positive, alpha-beta T cell number	J:267694
	increased effector memory CD8-positive, alpha-beta T cell number	J:267694
Il2rb^m2Btlr/Il2rb^m2Btlr C57BL/6J-Il2rb^m2Btlr	increased IgE level	J:272832
Il2rb^M3Btlr/Il2rb^M3Btlr C57BL/6J-Il2rb^M3Btlr	abnormal CD8-positive, alpha-beta T cell differentiation	J:272833
	abnormal T cell morphology	J:272833
	decreased CD8-positive, alpha-beta T cell number	J:272833
	decreased central memory CD8 positive, alpha-beta T cell number	J:272833
	decreased NK cell number	J:272833
	decreased NK T cell number	J:272833
	increased CD4-positive, alpha-beta T cell number	J:272833
	increased IgM level	J:272833
Il2rb^{tm1b(EUCOMM)Hmgu}/Il2rb^{tm1b(EUCOMM)Hmgu} C57BL/6N-Il2rb^{tm1b(EUCOMM)Hmgu}/Orl	abnormal autopod morphology	J:211773
	abnormal coat appearance	J:211773
	abnormal coat/ hair morphology	J:211773
	abnormal ear morphology	J:211773
	female infertility	J:211773
	male infertility	J:211773
Il2rb^tm1Mak/Il2rb^tm1Mak B6.129-Il2rb^tm1Mak	abnormal lymphocyte morphology	J:113547
	abnormal response to transplant	J:113547
	abnormal spleen periarteriolar lymphoid sheath morphology	J:113547
	abnormal T cell activation	J:113547
	decreased regulatory T cell number	J:113547
	decreased T cell proliferation	J:113547
	enlarged lymph nodes	J:113547
	enlarged spleen	J:113547
	increased anti-double stranded DNA antibody level	J:113547
	increased susceptibility to autoimmune hemolytic anemia	J:113547
Il2rb^tm1Mak/Il2rb^tm1Mak C.129-Il2rb^tm1Mak	abnormal immune system organ morphology	J:113547
	abnormal lymphocyte morphology	J:113547
	abnormal marginal zone B cell morphology	J:113547
	abnormal spleen periarteriolar lymphoid sheath morphology	J:113547
	abnormal T cell activation	J:113547
	abnormal T cell clonal deletion	J:113547
	decreased CD8-positive, alpha-beta T cell number	J:113547
	decreased T cell proliferation	J:113547
	enlarged lymph nodes	J:113547
	enlarged spleen	J:113547
	increased anti-double stranded DNA antibody level	J:113547
	increased susceptibility to autoimmune hemolytic anemia	J:113547
	liver inflammation	J:113547
	premature death	J:113547
Il2rb^tm1Mak/Il2rb^tm1Mak D2.129-Il2rb^tm1Mak	abnormal T cell clonal deletion	J:113547
Il2rb^tm1Mak/Il2rb^tm1Mak either: (involves: 129P2/OlaHsd) or (involves: 129S2/SvPas)	abnormal B cell activation	J:25940
	abnormal common myeloid progenitor cell morphology	J:25940
	abnormal hair texture	J:25940
	abnormal locomotor behavior	J:25940
	abnormal mononuclear cell morphology	J:25940
	abnormal sex gland morphology	J:25940
	abnormal T cell activation	J:25940
	decreased B cell number	J:25940
	decreased double-positive T cell number	J:25940
	decreased memory T cell number	J:25940
	enlarged lymph nodes	J:25940
	enlarged spleen	J:25940
	increased activated T cell number	J:25940
	increased anti-nuclear antigen antibody level	J:25940
	increased CD4-positive, alpha-beta T cell number	J:25940
	increased CD8-positive, alpha-beta T cell number	J:25940
	increased erythroid progenitor cell number	J:25940
	increased granulocyte number	J:25940
	increased IgE level	J:25940
	increased IgG1 level	J:25940
	increased neutrophil cell number	J:25940
	increased plasma cell number	J:25940
	increased susceptibility to autoimmune hemolytic anemia	J:25940
	premature death	J:25940
	thymus hypoplasia	J:25940
	weight loss	J:25940

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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