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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il4
interleukin 4
MGI:96556
105 phenotypes from 13 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
C.129P2/OlaHsd-Il4/Il13tm3Anjm 		abnormal interleukin-4 secretion J:91403
decreased IgE level J:91403
decreased interferon-gamma secretion J:91403
decreased interleukin-5 secretion J:91403
decreased interleukin-13 secretion J:91403
decreased susceptibility to autoimmune disorder J:91403
increased IgG2a level J:91403
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
C.Cg-Il4/Il13tm3Anjm 		decreased susceptibility to injury J:88681
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
involves: 129P2/OlaHsd * BALB/c 		abnormal mammary gland growth during pregnancy J:124116
abnormal splenocyte physiology J:60609
abnormal susceptibility to infection J:60609, J:131994
decreased IgG1 level J:178986
decreased inflammatory response J:60609, J:165513
ileum inflammation J:60609
increased susceptibility to parasitic infection J:60609
increased susceptibility to parasitic infection induced morbidity/mortality J:60609
Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
involves: 129P2/OlaHsd * C57BL/6 		abnormal immune system physiology J:89095
abnormal intestinal goblet cell morphology J:113543
abnormal splenocyte physiology J:72587
abnormal susceptibility to infection J:113543
abnormal T-helper 2 physiology J:89095
decreased IgE level J:72587, J:113543
decreased IgG1 level J:72587
decreased IgG level J:89095
decreased susceptibility to parasitic infection J:72587
granulomatous inflammation J:113543
increased eosinophil cell number J:113543
increased susceptibility to parasitic infection J:89095, J:113543
increased susceptibility to parasitic infection induced morbidity/mortality J:60609
Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
involves: 129 		decreased basophil cell number J:181313
decreased IgE level J:178986
decreased IgG1 level J:178986
decreased interleukin-4 secretion J:181313
Il4tm1(CD2)Mmrs/Il4tm1Lky
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:113279
Il4tm1.1Wep/Il4+
C.129P2-Il4tm1.1Wep 		decreased IgE level J:138827
Il4tm1.1Wep/Il4tm1.1Wep
C.129P2-Il4tm1.1Wep 		abnormal T-helper 2 cell differentiation J:138827
decreased IgE level J:138827
impaired eosinophil recruitment J:138827
Il4tm1.1Wep/Il4tm1.1Wep
involves: 129P2/OlaHsd * C57BL/6 		decreased interleukin-4 secretion J:67964
Il4tm1Cgn/Il4tm1Cgn
B6.129P2-Il4tm1Cgn/J 		abnormal skin physiology J:160119
normal immune system phenotype J:44346, J:160119
Il4tm1Cgn/Il4tm1Cgn
B6.Cg-Il4tm1Cgn 		abnormal humoral immune response J:89095
abnormal T-helper 2 physiology J:89095
Il4tm1Cgn/Il4tm1Cgn
either: NOD.129-Il4tm1Cgn or (involves: 129 * NOD) 		autoimmune response J:85924
insulitis J:85924
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss 		abnormal physiological response to xenobiotic J:119207
decreased IgG1 level J:119207
increased IgG2a level J:119207
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal cytokine secretion J:704
decreased IgE level J:704
decreased IgG1 level J:704
granulomatous inflammation J:113543
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp 		decreased IgE level J:39600
decreased IgG1 level J:39600
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * NOD 		abnormal cytokine secretion J:85924
decreased IgG1 level J:85924
Il4tm1Cgn/Il4tm1Cgn
MRL.129P2-Il4tm1Cgn 		lacrimal gland inflammation J:132514
Il4tm1Cgn/Il4tm1Cgn
NOD.129P2-Il4tm1Cgn 		abnormal enzyme/coenzyme activity J:105803
abnormal salivary gland physiology J:105803
decreased susceptibility to autoimmune disorder J:95105
increased circulating glucose level J:95105
increased susceptibility to autoimmune disorder J:95105
Il4tm1Cgn/Il4tm1Cgn
NOD.Cg-H2b Il4tm1Cgn 		abnormal enzyme/coenzyme activity J:105803
abnormal salivary gland physiology J:105803
lacrimal gland inflammation J:105803
salivary gland inflammation J:105803
Il4tm1Kopf/Il4tm1Kopf
involves: 129S2/SvPas 		decreased eosinophil cell number J:113065
decreased IgE level J:113065
decreased interleukin-5 secretion J:113065
Il4tm1Kopf/Il4tm1Kopf
involves: 129S2/SvPas * C57BL/6 		abnormal response to infection J:14593
decreased IgE level J:14593
decreased IgG1 level J:14593
decreased interleukin-3 secretion J:14593
decreased interleukin-4 secretion J:14593
decreased interleukin-5 secretion J:14593
decreased interleukin-10 secretion J:14593
increased IgG level J:14593
Il4tm1Nnt/Il4tm1Nnt
C57BL/6-Il4tm1Nnt/J 		abnormal microglial cell morphology J:125605
abnormal T-helper 2 physiology J:37196
CNS inflammation J:125605
decreased IgE level J:37196
decreased IgG1 level J:37196
decreased IgM level J:37196
decreased interleukin-4 secretion J:37196
decreased interleukin-5 secretion J:37196
decreased interleukin-10 secretion J:37196, J:120556
granulomatous inflammation J:37196
increased IgA level J:37196
increased interferon-gamma secretion J:37196, J:120556
stomach inflammation J:120556
Il4tm1Nnt/Il4tm1Nnt
involves: C57BL/6 		abnormal interleukin-4 secretion J:91403
decreased susceptibility to autoimmune disorder J:91403
Il4tm1Rao/Il4tm1Rao
involves: 129S6/SvEvTac * C57BL/6 		abnormal mast cell physiology J:78089
abnormal T-helper 2 physiology J:78089
decreased interleukin-4 secretion J:78089
decreased interleukin-13 secretion J:78089
Il4tm2.1Kubo/Il4tm2.1Kubo
B6.Cg-Il4tm2.1Kubo 		decreased airway responsiveness J:167446
decreased IgE level J:167446
decreased IgG1 level J:167446
decreased interleukin-4 secretion J:167446
impaired eosinophil recruitment J:167446
increased IgG2c level J:167446
increased interleukin-5 secretion J:167446
increased interleukin-13 secretion J:167446
Il4tm2Nnt/Il4tm2Nnt
BALB/c-Il4tm2Nnt 		abnormal splenocyte physiology J:60609
abnormal susceptibility to infection J:60609
ileum inflammation J:60609
increased susceptibility to parasitic infection J:60609
increased susceptibility to parasitic infection induced morbidity/mortality J:60609
Il4tm2Nnt/Il4tm2Nnt
BALB/c-Il4tm2Nnt/J 		abnormal dendritic cell antigen presentation J:141937
abnormal dendritic cell differentiation J:141937
abnormal kidney physiology J:84825
alveolar process atrophy J:147935
decreased IgE level J:31486
decreased IgG1 level J:31486
decreased interleukin-5 secretion J:141937
decreased interleukin-13 secretion J:141937
decreased susceptibility to autoimmune disorder J:141937
increased interferon-gamma secretion J:141937
Il4tm3.1Kubo/Il4tm3.1Kubo
B6.Cg-Il4tm3.1Kubo 		decreased interleukin-4 secretion J:167446
Tg(KRT14-Il4)#Lsch/0
involves: BALB/cBy * C57BL/6 		abnormal conjunctiva morphology J:126285
abnormal eyelid morphology J:126285
acanthosis J:126285
blepharitis J:126285
conjunctivitis J:126285
cornea scarring J:126285
decreased IgG2a level J:126285
dermatitis J:126285
dry skin J:126285
epidermal spongiosis J:126285
excessive scratching J:126285
hyperkeratosis J:126285
increased IgE level J:126285
increased IgG1 level J:126285
increased mast cell degranulation J:126285
increased pruritus J:126285
increased susceptibility to bacterial infection J:126285
parakeratosis J:126285
skin inflammation J:126285
spontaneous skin ulceration J:126285
Tg(LckIl4)1315Dbl/0
involves: C57BL/6J * DBA/2J 		abnormal osteoblast physiology J:107359
abnormal osteoclast physiology J:107359
abnormal T cell activation J:92453
abnormal T cell differentiation J:92453
abnormal T cell number J:92453
abnormal thymocyte activation J:92453
abnormal thymus cell ratio J:92453
abnormal thymus morphology J:92453
absent CD8-positive, alpha-beta T cells J:92453
decreased bone strength J:107359
decreased CD4-positive, alpha-beta T cell number J:92453
decreased compact bone thickness J:107359
decreased double-positive T cell number J:92453
decreased trabecular bone mass J:107359
increased CD4-positive, alpha-beta T cell number J:92453
increased CD8-positive, alpha-beta T cell number J:92453
increased circulating phosphate level J:107359
increased diameter of femur J:107359
increased double-negative T cell number J:92453
increased IgG2a level J:92453
increased interleukin-4 secretion J:92453
increased susceptibility to parasitic infection J:92453
kyphosis J:107359
osteoporosis J:107359
thymus cortex hypoplasia J:92453
thymus hypoplasia J:92453
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory