Il4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il4
interleukin 4
MGI:96556

74 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cigs2^tm1.1Anse/Cigs2⁺ Il4^tm1(CD2)Mmrs/Il4⁺ involves: 129 * BALB/cJ * C57BL/6	decreased basophil cell number	J:181313
	decreased IgE level	J:181313
	decreased IgG1 level	J:181313
	decreased interleukin-4 secretion	J:181313
	normal immune system phenotype	J:181313
Fas^lpr/Fas^lpr Il4^tm1Cgn/Il4^tm1Cgn involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp	abnormal lymph node size	J:39600
	abnormal spleen size	J:39600
	decreased anti-nuclear antigen antibody level	J:39600
	decreased circulating creatinine level	J:39600
	decreased IgA level	J:39600
	decreased IgE level	J:39600
	decreased IgG1 level	J:39600
	decreased IgG3 level	J:39600
	decreased immunoglobulin level	J:39600
	decreased susceptibility to systemic lupus erythematosus	J:39600
	enlarged spleen	J:39600
	increased spleen weight	J:39600
	spleen hyperplasia	J:39600
Fas^lpr/Fas^lpr Il4^tm1Cgn/Il4^tm1Cgn MRL.Cg-Il4^tm1Cgn Fas^lpr	glomerulonephritis	J:132514
	lacrimal gland inflammation	J:132514
Fbn1^Tsk/Fbn1⁺ Il4^tm1Nnt/Il4^tm1Nnt involves: C57BL/6 * C57BL/10 * DBA/2	decreased interleukin-4 secretion	J:57957
	emphysema	J:57957
	normal integument phenotype	J:57957
Il2^tm1Hor/Il2^tm1Hor Il4^tm1Cgn/Il4^tm1Cgn involves: 129P2/OlaHsd * C57BL/6	abnormal susceptibility to Riboviria infection	J:26861
	decreased cytotoxic T cell cytolysis	J:26861
	decreased IgG level	J:16662, J:26861
	increased B cell proliferation	J:16662
	increased pre-B cell number	J:16662
	increased pro-B cell number	J:16662
	increased T cell proliferation	J:16662
Il4/Il13^tm1.1Lky/Il4/Il13^tm1.1Lky Il4/Il13^tm1.1Lky/Il4/Il13^tm1.1Lky involves: 129P2/OlaHsd * BALB/c	decreased core body temperature	J:178294
	decreased fatty acids level	J:178294
	decreased noradrenaline level	J:178294
	increased susceptibility to weight loss	J:178294
Il4^tm1(CD2)Irvr/Il4⁺ involves: 129P2/OlaHsd * C57BL/6	normal cellular phenotype	J:111440
Il4^tm1(CD2)Irvr/Il4⁺ involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:111440
Il4^tm1.1Wep/Il4⁺ Stat6^tm1Gru/Stat6^tm1Gru C.129-Stat6^tm1Gru Il4^tm1.1Wep	abnormal T-helper 2 cell differentiation	J:138827
	decreased IgE level	J:138827
	impaired eosinophil recruitment	J:138827
Il4^tm1.1Wep/Il4^tm1.1Wep Stat6^tm1Gru/Stat6^tm1Gru C.129-Stat6^tm1Gru Il4^tm1.1Wep	abnormal T-helper 2 cell differentiation	J:138827
	decreased IgE level	J:138827
	impaired eosinophil recruitment	J:138827
Il4^tm1Cgn/Il4^tm1Cgn Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg} involves: 129P2/OlaHsd	esophageal epithelium hyperplasia	J:205692
	esophageal inflammation	J:205692
	increased CD4-positive, alpha-beta T cell number	J:205692
	increased eosinophil cell number	J:205692
	increased inflammatory response	J:205692
	increased interleukin-2 secretion	J:205692
	increased neutrophil cell number	J:205692
	increased T cell number	J:205692
	lung epithelium hyperplasia	J:205692
	lung inflammation	J:205692
	premature death	J:205692
Il4^tm1Cgn/Il4^tm1Cgn Tg(CD2-Stat6V625AT626A)78Mhk/0 involves: 129P2/OlaHsd * C3H * C57BL/6	normal integument phenotype	J:160119
Il4^tm1Cgn/Il4^tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 NOD.Cg-Il4^tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi	decreased susceptibility to autoimmune diabetes	J:85924
	insulitis	J:85924
Il4^tm1Gru/Il4^tm1Gru C.129-Il4^tm1Gru	no abnormal phenotype detected	J:53107
Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard involves: 129P2/OlaHsd * 129S2/SvPas	abnormal circulating complement protein level	J:161523
	decreased B cell number	J:161523
	decreased IgE level	J:161523
	decreased IgG1 level	J:161523
	increased anti-double stranded DNA antibody level	J:161523
	increased anti-nuclear antigen antibody level	J:161523
	increased basophil cell number	J:161523
	increased IgA level	J:161523
	increased IgG2a level	J:161523
	increased IgG2b level	J:161523
	increased IgM level	J:161523
	increased mast cell number	J:161523
Il4^tm1Lky/Il4⁺ Lat^tm1.1Mal/Lat^tm1.1Mal involves: 129S2/SvPas * C57BL/6	abnormal T-helper 2 physiology	J:151840
Il4^tm1Lky/Il4^tm1Lky Itk^tm1Litt/Itk^tm1Litt involves: 129S4/SvJae * BALB/c * C57BL/6J	abnormal cell death	J:129883
	abnormal cytokine secretion	J:129883
	abnormal response to infection	J:129883
	abnormal T-helper 2 physiology	J:129883
	normal immune system phenotype	J:129883
Il4^tm2Nnt/Il4^tm2Nnt Tgfb1^tm1Doe/Tgfb1^tm1Doe C.Cg-Tgfb1^tm1Doe Il4^tm2Nnt	increased circulating alanine transaminase level	J:69346
	liver inflammation	J:69346
	postnatal lethality, complete penetrance	J:69346
Il10^tm1Cgn/Il10^tm1Cgn Il4^tm1Cgn/Il4^tm1Cgn involves: 129P2/OlaHsd * C57BL/6	abnormal T-helper 1 cell differentiation	J:111712
	increased interferon-gamma secretion	J:111712
Il13^{tm1(YFP/cre)Lky}/Il13⁺ Il4^tm1(CD2)Mmrs/Il4⁺ Gt(ROSA)26Sor^tm1(DTA)Lky/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S4/SvJae	decreased eosinophil cell number	J:178986
	increased susceptibility to parasitic infection	J:178986
Il13^tm1Anjm/Il13⁺ Il4^tm1.1Wep/Il4⁺ involves: 129P2/OlaHsd * BALB/c * C57BL/6	decreased interleukin-4 secretion	J:69099
Il21r^tm1Wjl/Il21r^tm1Wjl Il4^tm1Cgn/Il4^tm1Cgn involves: 129 * C57BL/6	abnormal immunoglobulin level	J:80474
	abnormal lymph node germinal center morphology	J:80474
	decreased IgA level	J:80474
	decreased IgG1 level	J:80474
	decreased IgG2a level	J:80474
	decreased IgG2b level	J:80474
	decreased IgG3 level	J:80474
	decreased IgM level	J:80474

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24