Il5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il5
interleukin 5
MGI:96557

39 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il5^{tm1.1(icre)Lky}/Il5⁺ C57BL/6-Il5^{tm1.1(icre)Lky}	decreased circulating interleukin-5 level	J:206097
Il5^tm1Anjm/Il5^tm1Anjm involves: 129P2/OlaHsd * C57BL/6	abnormal intestinal goblet cell morphology	J:113543
	abnormal mast cell morphology	J:113543
	abnormal mast cell physiology	J:113543
	abnormal susceptibility to infection	J:113543
	decreased eosinophil cell number	J:113543
	decreased IgE level	J:113543
	granulomatous inflammation	J:113543
	increased susceptibility to parasitic infection	J:113543
Il5^tm1Kopf/Il5^tm1Kopf C57BL/6-Il5^tm1Kopf	decreased airway responsiveness	J:30641
	granulomatous inflammation	J:107418
	increased interferon-gamma secretion	J:107418
	increased lymphocyte cell number	J:30641
	increased neutrophil cell number	J:30641
	liver fibrosis	J:107418
Il5^tm1Kopf/Il5^tm1Kopf C57BL/6-Il5^tm1Kopf/J	increased eosinophil cell number	J:30867
Il5^tm1Kopf/Il5^tm1Kopf either: C57BL/6-Il5^tm1Kopf or (involves: BALB/c * C57BL/6) or (involves: C57BL/6 * CBA)	abnormal mating receptivity	J:65853
	enlarged placenta	J:65853
	increased body weight	J:65853
	prolonged estrous cycle	J:65853
Il5^tm1Ktk/Il5⁺ B6.129S4-Il5^tm1Ktk	decreased interleukin-5 secretion	J:180790
Il5^tm1Ktk/Il5^tm1Ktk B6.129S4-Il5^tm1Ktk	abnormal B-1 B cell morphology	J:180790
	decreased interleukin-5 secretion	J:180790
	increased metastatic potential	J:180790
Il5^tm3Anjm/Il5^tm3Anjm involves: 129P2/OlaHsd * C57BL/6	granulomatous inflammation	J:113543
Tg(Cd3d-Il5)NJ.1638Nal/? involves: C57BL/6J * CBA/J	abnormal eosinophil differentiation	J:123440
	abnormal liver morphology	J:123440
	abnormal spleen morphology	J:123440
	abnormal T cell number	J:123440
	alopecia	J:123440
	enlarged heart	J:123440
	enlarged lymph nodes	J:123440
	erythroblastosis	J:123440
	increased eosinophil cell number	J:123440
	increased leukocyte cell number	J:123440
	increased liver weight	J:123440
	increased mature B cell number	J:123440
	increased monocyte cell number	J:123440
	increased neutrophil cell number	J:123440
	increased spleen weight	J:123440
	peritoneal inflammation	J:123440
	premature death	J:123440
	rectal prolapse	J:123440
	spontaneous skin ulceration	J:123440

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24