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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il6
interleukin 6
MGI:96559
163 phenotypes from 8 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il6tm1.1Jho/Il6+
Tg(GFAP-cre)8Gtm/0
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA 		decreased locomotor activity J:211914
Il6tm1.1Jho/Il6tm1.1Jho
Tg(GFAP-cre)8Gtm/0
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA 		abnormal emotion/affect behavior J:211914
abnormal head movements J:211914
normal behavior/neurological phenotype J:211914
decreased locomotor activity J:211914
increased body weight J:211914
microgliosis J:211914
preweaning lethality, incomplete penetrance J:211914
Il6tm1Kopf/Il6tm1Kopf
B6.129S2-Il6tm1Kopf/J 		abnormal emotion/affect behavior J:146951
abnormal frequency of paradoxical sleep J:105279
abnormal glucose homeostasis J:109359
abnormal interleukin-6 secretion J:109359
abnormal pancreatic alpha cell mass J:139138
abnormal sleep pattern J:105279, J:136166
behavioral despair J:146951
decreased glucagon secretion J:139138
decreased insulin secretion J:139138
decreased interferon-gamma secretion J:123351
decreased pro-B cell number J:117320
decreased susceptibility to induced arthritis J:208213
impaired glucose tolerance J:139138
increased anxiety-related response J:96218, J:146951
increased body temperature J:105279, J:136166
increased fear-related response J:146951
increased interleukin-4 secretion J:123351
increased locomotor activity J:96218
Il6tm1Kopf/Il6tm1Kopf
C.129S2(B6)-Il6tm1Kopf 		increased tumor incidence following infection J:329456
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas 		abnormal glial cell morphology J:89814
abnormal inflammatory response J:160966
abnormal oval cell physiology J:66448
abnormal T cell physiology J:159479
decreased interleukin-17 secretion J:159479
decreased susceptibility to injury J:89814, J:145306
delayed wound healing J:160966
impaired wound healing J:160966
increased susceptibility to bacterial infection induced morbidity/mortality J:161073
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas * C57BL/6 		abnormal acute phase protein level J:17360
abnormal astrocyte morphology J:79142
abnormal axon morphology J:79142
abnormal bone healing J:141482
abnormal brain interneuron morphology J:148881
abnormal capillary morphology J:150895
abnormal cardiovascular system physiology J:150895
abnormal CNS glial cell morphology J:79142
abnormal emotion/affect behavior J:147420
abnormal exercise endurance J:105633
abnormal heart development J:150895
abnormal heart morphology J:150895
abnormal heart ventricle morphology J:150895
abnormal homeostasis J:105633
abnormal inhibitory learning J:147420
abnormal interventricular septum morphology J:150895
abnormal involution of the mammary gland J:125449
abnormal learning/memory/conditioning J:147420
abnormal long-term object recognition memory J:148881
abnormal microglial cell morphology J:79142
abnormal myoblast migration J:131016
abnormal nervous system physiology J:148881
abnormal neuron morphology J:79142
abnormal neuron physiology J:148881
abnormal object recognition memory J:147420, J:148881
abnormal oxygen consumption J:105633
abnormal pulmonary gas exchange J:105633
abnormal skeletal muscle fiber morphology J:131016
abnormal skeletal muscle satellite cell proliferation J:131016
abnormal spatial learning J:147420
abnormal T cell differentiation J:17360
behavioral despair J:147420
decreased body weight J:105633
decreased bone mineral density J:141482
decreased cardiac muscle contractility J:150895
decreased cytotoxic T cell cytolysis J:17360
decreased heart left ventricle anterior wall thickness J:150895
decreased heart left ventricle posterior wall thickness J:150895
decreased heart left ventricle wall thickness J:150895
decreased heart weight J:150895
decreased incidence of tumors by chemical induction J:122816
decreased T cell number J:17360
dilated heart left ventricle J:150895
hepatic necrosis J:122816
impaired long-term object recognition memory J:147420
increased anxiety-related response J:147420
increased circulating glucose level J:105633
increased susceptibility to bacterial infection J:17360
increased susceptibility to induced colitis J:79073
increased susceptibility to Poxviridae infection J:17360
liver degeneration J:122816
obese J:105633
retina outer nuclear layer degeneration J:136895
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas * C57BL/6J * CE/J 		seizures J:63197
Il6tm1Kopf/Il6tm1Kopf
Tg(Rorc-EGFP)1Ebe/?
involves: 129S2/SvPas * C57BL/6 		abnormal effector T cell morphology J:137020
Il6tm1Mur/Il6+
B6.129P2(B6)-Il6tm1Mur 		abnormal dopamine level J:86039
Il6tm1Mur/Il6tm1Mur
B6.129P2(B6)-Il6tm1Mur 		abnormal bone mineral density J:65093
abnormal dopamine level J:86039
abnormal inflammatory response J:85581
abnormal microglial cell morphology J:85581
abnormal microglial cell physiology J:85581
abnormal osteoblast differentiation J:65093
abnormal osteoclast differentiation J:65093
abnormal osteoclast physiology J:65093
abnormal substantia nigra pars compacta morphology J:86039
abnormal trabecular bone morphology J:65093
gliosis J:85581
increased susceptibility to dopaminergic neuron neurotoxicity J:86039
Il6tm1Mur/Il6tm1Mur
involves: 129/Sv * C57BL/6 		abnormal interferon level J:40579
abnormal lymphocyte cell number J:40579
absent NK cells J:40579
brain inflammation J:40579
increased susceptibility to parasitic infection J:40579
Il6tm1Mur/Il6tm1Mur
involves: 129P2/OlaHsd * C57BL/6 		abnormal neutrophil physiology J:25684
normal immune system phenotype J:25684
increased susceptibility to bacterial infection J:25684
Il6tm1Poli/Il6tm1Poli
CAnNCrl.129S(Cg)-Il6tm1Poli 		abnormal B cell proliferation J:42869
abnormal behavior J:96706
abnormal body weight J:96706
abnormal immune system physiology J:96706
abnormal social investigation J:96706
abnormal stationary movement J:96706
decreased incidence of induced tumors J:42869
decreased inflammatory response J:42869
Il6tm1Poli/Il6tm1Poli
involves: 129S/SvEv * C57BL/6 		abnormal food intake J:48865
abnormal liver morphology J:37026
decreased inflammatory response J:68063
decreased susceptibility to injury J:68063
normal growth/size/body region phenotype J:48865
hepatic necrosis J:37026
impaired febrile response J:48865
impaired liver regeneration J:37026
impaired neutrophil recruitment J:68063
increased susceptibility to induced morbidity/mortality J:37026, J:48865
liver failure J:37026
Il6tm1Poli/Il6tm1Poli
involves: 129S/SvEv * MF1 		abnormal bone remodeling J:17249
abnormal learning/memory/conditioning J:95923
abnormal macrophage physiology J:79314
abnormal mechanical nociception J:89398
abnormal neutrophil physiology J:79314
abnormal osteoclast physiology J:17249
abnormal passive avoidance behavior J:95923
abnormal social investigation J:53180
abnormal spatial learning J:95923
abnormal T-helper 1 cell morphology J:79314
abnormal T-helper 1 physiology J:79314
abnormal T-helper 2 physiology J:79314
abnormal trabecular bone morphology J:17249
normal behavior/neurological phenotype J:95923
decreased chemically-elicited antinociception J:89398
decreased circulating interleukin-12 level J:79314
decreased compact bone thickness J:17249
decreased dopamine level J:53180
decreased IgA level J:79314
decreased IgE level J:79314
enhanced behavioral response to morphine J:89398
normal homeostasis/metabolism phenotype J:30643
normal immune system phenotype J:17249
impaired febrile response J:30643
increased aggression towards male mice J:53180
increased circulating interleukin-10 level J:79314
increased IgG2a level J:79314
increased susceptibility to fungal infection J:79314
normal mortality/aging J:17249
Tg(Gfap-Il6)G16Lms/0
Tg(Gfap-lacZ)1Lms/0
involves: C57BL/6J * SJL 		abnormal cerebellar molecular layer J:125549
abnormal pilomotor reflex J:125549
astrocytosis J:125549
ataxia J:125549
decreased body size J:125549
hunched posture J:125549
normal immune system phenotype J:125549
paraparesis J:125549
premature death J:125549
ruffled hair J:125549
seizures J:125549
tremors J:125549
vascular inflammation J:125549
Tg(Gfap-Il6)G167Lms/0
involves: C57BL/6J * SJL 		abnormal physiological neovascularization J:125549
abnormal pilomotor reflex J:125549
astrocytosis J:125549
ataxia J:125549
decreased body size J:125549
hunched posture J:125549
paraparesis J:125549
premature death J:125549
seizures J:125549
tremors J:125549
Tg(Gfap-Il6)G167Lms/Tg(Gfap-Il6)G167Lms
involves: C57BL/6J * SJL 		abnormal astrocyte morphology J:137907
abnormal axon morphology J:137907
abnormal behavior J:125549
abnormal brain white matter morphology J:137907
abnormal cerebellar granule cell morphology J:137907
abnormal cerebellar molecular layer J:125549
abnormal dendrite morphology J:125549
abnormal neuron morphology J:137907
abnormal physiological neovascularization J:125549
abnormal pilomotor reflex J:125549
abnormal Purkinje cell dendrite morphology J:125549
astrocytosis J:125549
ataxia J:125549
decreased body size J:125549
decreased neuron number J:137907
decreased Purkinje cell number J:137907
gliosis J:137907
hunched posture J:125549
normal nervous system phenotype J:137907
neurodegeneration J:125549
paraparesis J:125549
seizures J:125549
spongiform encephalopathy J:137907
tremors J:125549
Tg(Gfap-Il6)G369Lms/0
involves: C57BL/6J * SJL 		abnormal astrocyte morphology J:125549
abnormal behavior J:125549
abnormal cerebellar molecular layer J:125549
abnormal dendrite morphology J:125549
abnormal physiological neovascularization J:125549
abnormal pilomotor reflex J:125549
abnormal Purkinje cell dendrite morphology J:125549
astrocytosis J:125549
ataxia J:125549
decreased body size J:125549
hunched posture J:125549
normal immune system phenotype J:125549
neurodegeneration J:125549
paraparesis J:125549
ruffled hair J:125549
seizures J:125549
tremors J:125549
vascular inflammation J:125549
Tg(Gfap-Il6)G369Lms/Tg(Gfap-Il6)G369Lms
involves: C57BL/6J * SJL 		abnormal astrocyte morphology J:137907
abnormal axon morphology J:137907
abnormal brain white matter morphology J:137907
abnormal cerebellar granule cell morphology J:137907
abnormal neuron morphology J:137907
decreased neuron number J:137907
decreased Purkinje cell number J:137907
gliosis J:137907
normal nervous system phenotype J:137907
spongiform encephalopathy J:137907
Tg(Il6)1Efu/0
Not Specified 		alopecia J:1133
decreased body weight J:1133
hyperkeratosis J:1133
scaly skin J:1133
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory