Il6 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il6
interleukin 6
MGI:96559

44 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Il6^tm1Kopf/Il6^tm1Kopf involves: 129S2/SvPas * C57BL/6	abnormal tumor incidence	J:130429
	normal adipose tissue phenotype	J:130429
	normal muscle phenotype	J:130429
Ash1l^{Tn(pb-Act-RFP)1.AF0-180T25Zhu}/Ash1l^{Tn(pb-Act-RFP)1.AF0-180T25Zhu} Il6^tm1Kopf/Il6^tm1Kopf B6.Cg-Ash1l^{Tn(pb-Act-RFP)1.AF0-180T25Zhu} Il6^tm1Kopf	abnormal inflammatory response	J:208213
	increased susceptibility to induced arthritis	J:208213
Cebpb^tm1Vpo/Cebpb^tm1Vpo Il6^tm1Poli/Il6^tm1Poli involves: 129S/SvEv * MF1	normal hematopoietic system phenotype	J:35883
Ctsc^tm1Ley/Ctsc^tm1Ley Il6^tm1Kopf/Il6^tm1Kopf involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	normal immune system phenotype	J:88160
Foxp3^tm1Kuch/? Il6^tm1Kopf/Il6^tm1Kopf involves: 129S2/SvPas * C57BL/6	abnormal CD4-positive T cell differentiation	J:123352
	decreased circulating interleukin-6 level	J:123352
	decreased interleukin-17 secretion	J:123352
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:123352
	increased regulatory T cell number	J:123352
Galc^twi/Galc^twi Il6^tm1Kopf/Il6^tm1Kopf involves: 129S2/SvPas * C57BL/6J * CE/J	abnormal blood-brain barrier function	J:56656
	abnormal cerebellum white matter morphology	J:56656
	abnormal tumor necrosis factor level	J:56656
	gliosis	J:56656
	tremors	J:56656
Il6^tm1Kopf/Il6⁺ Prdm1^tm1Clme/Prdm1^tm1Clme Tg(Itgax-cre)1-1Reiz/0 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA	normal immune system phenotype	J:178876
Il6^tm1Kopf/Il6⁺ Tg(ED-L2-IL1RN/IL1B)#Tcw/? B6.Cg-Il6^tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw	normal digestive/alimentary phenotype	J:180282
	esophageal inflammation	J:180282
Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺ involves: 129 * 129S2/SvPas * C57BL/6	abnormal epididymis physiology	J:284227
	enhanced male fertility	J:284227
	increased sperm motility	J:284227
	increased sperm progressive motility	J:284227
	teratozoospermia	J:284227
Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺ involves: 129S2/SvPas * BALB/c * C57BL/6	normal homeostasis/metabolism phenotype	J:207622
Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺ involves: 129S2/SvPas * C57BL/6	normal homeostasis/metabolism phenotype	J:207622
	increased hepatocellular carcinoma incidence	J:207622
	normal reproductive system phenotype	J:207622
Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5^tm1Hxia involves: 129S2/SvPas * C57BL/6	preweaning lethality, complete penetrance	J:207622
Il6^tm1Kopf/Il6^tm1Kopf Il6ra^tm1.2Drew/Il6ra^tm1.2Drew involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL	abnormal wound healing	J:160966
Il6^tm1Kopf/Il6^tm1Kopf Il6st^tm1Ern/Il6st^tm1Ern involves: 129S1/Sv * 129S2/SvPas	decreased susceptibility to endotoxin shock	J:168781
	normal immune system phenotype	J:139226
Il6^tm1Kopf/Il6^tm1Kopf Inpp5d^tm1Rkh/Inpp5d^tm1Rkh involves: 129 * C57BL/6	abnormal hematopoietic stem cell morphology	J:117320
	abnormal lymphopoiesis	J:117320
	abnormal myelopoiesis	J:117320
	decreased pro-B cell number	J:117320
Il6^tm1Kopf/Il6^tm1Kopf Junb^tm3Wag/Junb^tm3Wag Tg(KRT5-cre)1Tak/0 involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6	normal homeostasis/metabolism phenotype	J:155575
	hyperkeratosis	J:155575
	normal immune system phenotype	J:155575
	normal integument phenotype	J:155575
	normal mortality/aging	J:155575
	normal renal/urinary system phenotype	J:155575
	skin inflammation	J:155575
	thick skin	J:155575
Il6^tm1Kopf/Il6^tm1Kopf Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * 129S2/SvPas * C57BL/6	abnormal glial cell morphology	J:89814
	decreased susceptibility to injury	J:89814
Il6^tm1Kopf/Il6^tm1Kopf Npc1^m1N/Npc1^m1N involves: 129S2/SvPas * BALB/c * C57BL/6	abnormal glial cell physiology	J:118352
Il6^tm1Kopf/Il6^tm1Kopf Tank^tm1Aki/Tank^tm1Aki involves: 129/Sv * 129S2/SvPas * C57BL/6	normal immune system phenotype	J:151757
Il6^tm1Kopf/Il6^tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw/? B6.Cg-Il6^tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw	normal digestive/alimentary phenotype	J:180282
	esophageal inflammation	J:180282
Il6^tm1Kopf/Il6^tm1Kopf Tg(H2-K-IL6)2Srj/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	normal hematopoietic system phenotype	J:185153
Il11ra1^tm1Wehi/Il11ra1^tm1Wehi Il6^tm1Kopf/Il6^tm1Kopf involves: 129/Sv * C57BL/6	increased susceptibility to induced colitis	J:79073

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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