Il7r Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il7r
interleukin 7 receptor
MGI:96562

40 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il7r^{tm1.1(icre)Hrr}/Il7r⁺ involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:158903
Il7r^tm1.1Asin/Il7r^tm1Imx Tg(Cd4-cre)1Cwi/0 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2	decreased CD8-positive, alpha-beta T cell number	J:190889
Il7r^tm1.1Asin/Il7r^tm1Imx Tg(Cd8a-cre)B8Asin/0 involves: 129S7/SvEvBrd C57BL/6	decreased CD8-positive, alpha-beta T cell number	J:190889
Il7r^tm1Abra/Il7r^tm1Abra B6.129S4-Il7r^tm1Abra	abnormal CD4-positive, alpha-beta T cell physiology	J:125360
	abnormal T cell differentiation	J:125360
	abnormal T cell proliferation	J:125360
	decreased B cell number	J:125360
	decreased CD4-positive, alpha-beta T cell number	J:125360
	decreased CD8-positive, alpha-beta T cell number	J:125360
	decreased memory T cell number	J:125360
	decreased thymocyte number	J:125360
	increased double-positive T cell number	J:125360
Il7r^tm1Iku/Il7r^tm1Iku involves: 129P2/OlaHsd * C57BL/6J	abnormal B cell differentiation	J:34658
	abnormal gamma-delta T cell differentiation	J:34658
	abnormal T cell subpopulation ratio	J:34658
	absent mature gamma-delta T cells	J:34658
	absent Peyer's patches	J:45633
	decreased B-1 B cell number	J:34658
	decreased bone marrow cell number	J:34658
	decreased double-positive T cell number	J:34658
	decreased immature B cell number	J:34658
	decreased leukocyte cell number	J:34658
	decreased lymphocyte cell number	J:34658
	decreased mature B cell number	J:34658
	decreased T cell number	J:34658
	normal immune system phenotype	J:34658
	increased double-negative T cell number	J:34658
	small thymus	J:34658
	spleen hypoplasia	J:34658
	thymus hypoplasia	J:34658
Il7r^tm1Imx/Il7r^tm1Imx B6.129S7-Il7r^tm1Imx	abnormal T cell differentiation	J:125360
	decreased double-positive T cell number	J:125360
	decreased thymocyte number	J:125360
Il7r^tm1Imx/Il7r^tm1Imx involves: 129P3/J * 129S7/SvEvBrd	arrested B cell differentiation	J:21135
	arrested T cell differentiation	J:21135
	decreased B cell number	J:21135
	decreased T cell number	J:21135
	lymph node hypoplasia	J:21135
	spleen hypoplasia	J:21135
	thymus hypoplasia	J:21135
Il7r^tm1Imx/Il7r^tm1Imx involves: 129S7/SvEvBrd	decreased thymocyte number	J:64861
Il7r^tm1Imx/Il7r^tm1Imx Tg(Lck-Il7r)1676Trma/? involves: 129S7/SvEvBrd * C57BL/6 * SJL	decreased T cell proliferation	J:66400
	decreased thymocyte number	J:66400
	increased thymocyte apoptosis	J:66400
Il7r^tm2Iku/Il7r^tm2Iku Tg(Cd4-cre)1Cwi/? involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal CD4-positive T cell differentiation	J:193283
	abnormal CD8-positive, alpha-beta T cell differentiation	J:193283
	abnormal T cell morphology	J:193283
	decreased NK T cell number	J:193283
	increased B cell number	J:193283
	increased gamma-delta T cell number	J:193283
	increased thymocyte number	J:193283

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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