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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ins1
insulin I
MGI:96572
40 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Clic4tm1.1Thor/Clic4tm1.1Thor
Ins1tm1.1(cre)Thor/Ins1+
involves: C57BL/6J 		decreased pancreatic islet cell apoptosis J:223517
normal homeostasis/metabolism phenotype J:223517
Ins1tm1.1(cre)Thor/Ins1+
Tpcn2tm1c(EUCOMM)Hmgu/Tpcn2tm1c(EUCOMM)Hmgu
involves: C57BL/6J * C57BL/6N 		no abnormal phenotype detected J:235705
Ins1tm1.1(cre)Thor/Ins1+
Larp1tm1c(EUCOMM)Hmgu/Larp1tm1c(EUCOMM)Hmgu
involves: C57BL/6J * C57BL/6N 		normal homeostasis/metabolism phenotype J:300456
Ins1tm1.1(cre)Thor/Ins1+
Syt13tm1c(EUCOMM)Hmgu/Syt13tm1c(EUCOMM)Hmgu
involves: C57BL/6J * C57BL/6N 		normal endocrine/exocrine gland phenotype J:327292
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1.1Mnt/Ins2tm1.1Mnt
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N 		postnatal lethality, complete penetrance J:152798
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2+
involves: 129S2/SvPas * C57BL/6 		increased pancreatic alpha cell mass J:106827
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
involves: 129S2/SvPas 		abnormal glucose homeostasis J:40377, J:77595
acidosis J:40377
decreased body size J:40377
embryonic growth retardation J:40377
enlarged liver J:40377
enlarged pancreatic islets J:40377
hepatic steatosis J:40377
increased circulating triglyceride level J:40377
increased pancreatic beta cell number J:77595
increased urine glucose level J:40377
postnatal lethality, complete penetrance J:40377
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
involves: 129S2/SvPas * C57BL/6 		decreased birth weight J:106827
decreased fetal weight J:106827
decreased pancreatic islet cell apoptosis J:106827
enlarged pancreatic islets J:106827
increased pancreatic alpha cell mass J:106827
increased pancreatic alpha cell proliferation J:106827
increased pancreatic beta cell mass J:106827
increased pancreatic beta cell proliferation J:106827
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0
NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell 		decreased susceptibility to autoimmune diabetes J:98583
increased circulating glucose level J:98583
salivary gland inflammation J:98583
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0
NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)3Ell 		decreased anti-insulin autoantibody level J:98583
decreased susceptibility to autoimmune diabetes J:98583
salivary gland inflammation J:98583
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Mnt/Ins2tm1Mnt
Tg(Aire-cre)1Mnt/0
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal circulating insulin level J:152798
abnormal immune system physiology J:152798
abnormal interferon-gamma secretion J:152798
abnormal pancreatic beta cell physiology J:152798
abnormal T cell physiology J:152798
decreased pancreatic beta cell number J:152798
hyperglycemia J:152798
increased anti-insulin autoantibody level J:152798
increased circulating glucose level J:152798
pancreas inflammation J:152798
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0
NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell 		increased circulating glucose level J:98583
increased susceptibility to autoimmune diabetes J:98583
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)3Ell/0
NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)3Ell 		autoimmune response J:98583
Nnattm1.1Geno/Nnat+
Ins1tm1.1(cre)Thor/Ins1+
involves: 129S2/SvPas * C57BL/6J 		decreased insulin secretion J:265677
impaired glucose tolerance J:265677
increased fasting circulating glucose level J:265677
maternal imprinting J:265677
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory