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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ins2
insulin II
MGI:96573
91 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ins2Akita/Ins2+
C57BL/6-Ins2Akita 		abnormal Leydig cell morphology J:108948
abnormal mitochondrial morphology J:108948
abnormal pancreatic beta cell morphology J:47883
akinesia J:125256
decreased body weight J:125256
decreased bone mineral density J:108948
decreased circulating insulin level J:40063
decreased insulin secretion J:40063, J:47883
decreased locomotor activity J:125256
decreased subcutaneous adipose tissue amount J:108948
degranulated pancreatic beta cells J:47883
hydronephrosis J:40063
hyperglycemia J:40063, J:125256
impaired glucose tolerance J:40063
increased anxiety-related response J:125256
increased fluid intake J:125256
kyphosis J:108948
polydipsia J:40063
polyphagia J:125256
polyuria J:40063
postnatal growth retardation J:40063
premature death J:40063, J:108948
Ins2Akita/Ins2+
C57BL/6-Ins2Akita/J 		abnormal astrocyte morphology J:99412
abnormal microglial cell morphology J:99412
abnormal pancreatic islet morphology J:321591
abnormal response to transplant J:76224
abnormal retina ganglion layer morphology J:99412
abnormal retina neuronal layer morphology J:99412
abnormal retina vasculature morphology J:99412
decreased body weight J:99412, J:321591
decreased circulating insulin level J:321591
decreased pancreatic beta cell number J:321591
decreased respiratory quotient J:321591
hyperglycemia J:76224, J:99412
impaired glucose tolerance J:321591
increased energy expenditure J:321591
increased insulin sensitivity J:76224
increased leukocyte cell number J:99412
increased retina apoptosis J:99412
increased vascular permeability J:99412
Ins2Akita/Ins2+
C.B6N-Ins2Akita 		albuminuria J:198186
expanded mesangial matrix J:198186
glomerulosclerosis J:198186
increased renal glomerular filtration rate J:198186
Ins2Akita/Ins2+
involves: C3H * C57BL/6NJcl * C57BL/6NSlc 		hyperglycemia J:40063
impaired glucose tolerance J:40063
Ins2Akita/?
involves: C57BL/6NSlc 		abnormal cardiac muscle contractility J:130021
abnormal glucose homeostasis J:130021
abnormal heart left ventricle morphology J:130021
abnormal heart morphology J:130021
decreased adipocyte glucose uptake J:130021
decreased body fat mass J:130021
decreased body weight J:130021
decreased circulating insulin level J:130021
decreased circulating triglyceride level J:130021
decreased liver triglyceride level J:130021
decreased locomotor activity J:130021
decreased respiratory quotient J:130021
decreased skeletal muscle cell glucose uptake J:130021
decreased skeletal muscle triglyceride level J:130021
heart left ventricle hypertrophy J:130021
hyperglycemia J:130021
increased adipocyte glucose uptake J:130021
increased carbon dioxide production J:130021
increased energy expenditure J:130021
increased food intake J:130021
increased oxygen consumption J:130021
insulin resistance J:130021
thick interventricular septum J:130021
Ins2Akita/Ins2+
involves: C57BL/6NSlc 		abnormal pancreatic islet morphology J:200802
decreased body weight J:200802
decreased circulating leptin level J:200802
decreased insulin secretion J:200802
normal homeostasis/metabolism phenotype J:200802
increased circulating glucose level J:200802
increased food intake J:200802
Ins2Akita/Ins2Akita
C57BL/6-Ins2Akita 		abnormal pancreatic alpha cell morphology J:47883
abnormal pancreatic beta cell morphology J:47883
decreased insulin secretion J:47883
hyperglycemia J:47883
postnatal lethality J:47883
small pancreatic islets J:47883
Ins2Akita/Ins2Akita
C57BL/6-Ins2Akita/J 		hyperglycemia J:76224
premature death J:76224
Ins2Akita/Ins2Akita
C.B6N-Ins2Akita 		abnormal glomerular capillary morphology J:198186
abnormal kidney interstitium morphology J:198186
albuminuria J:198186
decreased body weight J:198186
expanded mesangial matrix J:198186
glomerulosclerosis J:198186
hyperglycemia J:198186
increased renal glomerular filtration rate J:198186
increased renal glomerulus basement membrane thickness J:198186
premature death J:198186
renal glomerular protein deposits J:198186
Ins2Akita/Ins2Akita
involves: C57BL/6NSlc 		abnormal pancreas physiology J:156725
decreased circulating insulin level J:156725
decreased insulin secretion J:156725
decreased pancreatic beta cell mass J:156725
hematoma J:168556
hyperglycemia J:156725
increased pancreatic islet cell apoptosis J:156725
Ins2C95S/Ins2+
C3HeB/FeJ-Ins2C95S 		abnormal pancreatic beta cell morphology J:122098
abnormal pancreatic beta cell physiology J:122098
abnormal pancreatic islet morphology J:122098
decreased body weight J:122098
decreased circulating insulin level J:122098
decreased insulin secretion J:122098
decreased pancreatic beta cell number J:122098
disorganized pancreatic islets J:122098
hyperglycemia J:122098, J:137483
increased circulating glucose level J:122098
increased pancreatic alpha cell number J:122098
increased susceptibility to autoimmune diabetes J:122098
increased urine glucose level J:122098
insulin resistance J:122098
Ins2C95S/Ins2C95S
C3HeB/FeJ-Ins2C95S 		decreased body weight J:122098
increased circulating glucose level J:122098
increased susceptibility to autoimmune diabetes J:122098
increased urine glucose level J:122098
premature death J:122098
Ins2em#Arak/Ins2+
C.129-Rag2tm1Fwa Ins2em#Arak Jak3tm1Tks/Arak 		abnormal homeostasis J:294041
abnormal pancreatic beta cell morphology J:294041
abnormal pancreatic islet morphology J:294041
hyperglycemia J:294041
impaired glucose tolerance J:294041
polyuria J:294041
small pancreatic islets J:294041
Ins2tm1(cre/ERT2)Kcmm/Ins2tm1(cre/ERT2)Kcmm
Not Specified 		normal homeostasis/metabolism phenotype J:171567
Ins2tm1Jja/Ins2tm1Jja
involves: 129S2/SvPas 		increased insulin secretion J:77595
increased pancreatic beta cell mass J:77595
increased pancreatic beta cell number J:77595
Ins2tm1Jja/Ins2tm1Jja
NOD.129S2-Ins2tm1Jja 		abnormal glucose homeostasis J:85309
increased anti-insulin autoantibody level J:85309
insulitis J:85309
Ins2tm1Nagy/Ins2tm1Nagy
involves: 129S1/Sv * 129X1/SvJ * Hsd:ICR 		no abnormal phenotype detected J:153719
Ins2tm1Rll/Ins2tm1Rll
Not Specified 		normal homeostasis/metabolism phenotype J:196410
Tg(H2-Ea-Ins2)1Wehi/0
NOD/ShiLtJWehi-Tg(H2-Ea-Ins2)1Wehi 		abnormal T cell proliferation J:100232
normal endocrine/exocrine gland phenotype J:100232
normal immune system phenotype J:100232
salivary gland inflammation J:100232
Tg(H2-Ea-Ins2)1Wehi/Tg(H2-Ea-Ins2)1Wehi
NOD/ShiLtJWehi-Tg(H2-Ea-Ins2)1Wehi 		abnormal CD8-positive, alpha beta T cell morphology J:117352
decreased anti-insulin autoantibody level J:117352
decreased T cell proliferation J:117352
normal hematopoietic system phenotype J:117352
normal immune system phenotype J:117352
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory