Insr Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Insr
insulin receptor
MGI:96575

69 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	increased circulating ketone body level	J:91350
	postnatal lethality, complete penetrance	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Camk2a-cre)#Szi/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Hsp70-1-cre)6Arge/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Nes-cre)1Kln/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actb^tm1(INSR)Dac/Actb^tm1(INSR)Dac Insr^tm1Dac/Insr^tm1Dac Tg(Syn1-cre)671Jxm/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr⁺ involves: 129S4/SvJae * C57BL/6	normal homeostasis/metabolism phenotype	J:79560
Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr^tm1Dac involves: 129S4/SvJae * C57BL/6	decreased circulating glucose level	J:79560
	postnatal lethality	J:79560
Foxo1^tm2.1Dac/Foxo1^tm2.1Dac Insr^tm1Dac/Insr⁺ involves: 129S4/SvJae * C57BL/6	increased circulating insulin level	J:179687
	insulin resistance	J:179687
Gsk3b^tm1Jrw/Gsk3b⁺ Insr^tm1Dac/Insr⁺ involves: 129 * C57BL/6J	abnormal circulating glucose level	J:135659
	abnormal circulating insulin level	J:135659
	decreased pancreatic beta cell mass	J:135659
	improved glucose tolerance	J:135659
	insulin resistance	J:135659
Igf1r^tm1.1Mhz/Igf1r⁺ Insr^tm1Khn/Insr^tm1Khn Tg(Ckmm-cre)5Khn/0 involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB	abnormal breathing pattern	J:118987
	decreased heart left ventricle muscle contractility	J:118987
	decreased locomotor activity	J:118987
	normal homeostasis/metabolism phenotype	J:118987
	premature death	J:118987
Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz Insr^tm1Khn/Insr⁺ Tg(Ckmm-cre)5Khn/0 involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB	normal cardiovascular system phenotype	J:118987
	normal growth/size/body region phenotype	J:118987
	normal homeostasis/metabolism phenotype	J:118987
Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz Insr^tm1Khn/Insr^tm1Khn involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB	normal cardiovascular system phenotype	J:118987
	normal growth/size/body region phenotype	J:118987
	normal homeostasis/metabolism phenotype	J:118987
Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz Insr^tm1Khn/Insr^tm1Khn Tg(Ckmm-cre)5Khn/0 involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB	abnormal breathing pattern	J:118987
	abnormal heart left ventricle morphology	J:118987
	abnormal myocardial fiber morphology	J:118987
	cardiac interstitial fibrosis	J:118987
	congestive heart failure	J:118987
	decreased body weight	J:118987
	decreased heart left ventricle muscle contractility	J:118987
	decreased heart rate	J:118987
	decreased heart weight	J:118987
	decreased locomotor activity	J:118987
	decreased myocardial fiber size	J:118987
	dilated cardiomyopathy	J:118987
	normal homeostasis/metabolism phenotype	J:118987
	postnatal growth retardation	J:118987
	postnatal lethality, complete penetrance	J:118987
	small heart	J:118987
	thin interventricular septum	J:118987
	thin ventricular wall	J:118987
Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	abnormal primary sex determination	J:86618
	primary sex reversal	J:86618
Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	ovotestis	J:86618
	primary sex reversal	J:86618
Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	abnormal primary sex determination	J:86618
	primary sex reversal	J:86618
Insr^tm1Dac/Insr⁺ Irs2^tm1Mfw/Irs2^tm1Mfw involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal glucose homeostasis	J:80826
	absent pancreatic beta cells	J:80826
	postnatal lethality	J:80826
Insr^tm1Dac/Insr⁺ Sox4^Igt4/Sox4⁺ involves: C3H/HeH * C57BL/6	impaired glucose tolerance	J:141688
Insr^tm1Dac/Insr⁺ Ppp2r2a^igt10/Ppp2r2a⁺ involves: 129S4/SvJae * C3H/HeH * C57BL/6J	hyperglycemia	J:246319
	impaired glucose tolerance	J:246319
	increased circulating insulin level	J:246319
	increased pancreatic beta cell mass	J:246319
	increased urine glucose level	J:246319
	insulin resistance	J:246319
	polydipsia	J:246319
Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac involves: 129S1/Sv * 129S4/SvJae * C57BL/6J	hyperglycemia	J:70602
	impaired glucose tolerance	J:70602
	increased circulating insulin level	J:70602
	ketoaciduria	J:70602
	postnatal lethality, complete penetrance	J:70602
Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L1Dac/0 involves: 129S4/SvJae * C57BL/6 * FVB	decreased birth weight	J:91350
	decreased pancreatic beta cell mass	J:91350
	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	increased energy expenditure	J:91350
	increased growth rate	J:91350
	normal reproductive system phenotype	J:91350
Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L2Dac/0 involves: 129S4/SvJae * C57BL/6 * FVB	abnormal liver physiology	J:91350
	abnormal pancreatic islet morphology	J:91350
	decreased birth weight	J:91350
	decreased liver glycogen level	J:91350
	decreased white adipose tissue amount	J:91350
	enlarged liver	J:91350
	female infertility	J:91350
	hepatic steatosis	J:91350
	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	increased pancreatic beta cell mass	J:91350
	liver degeneration	J:91350
	postnatal growth retardation	J:91350
	premature death	J:91350
Insr^tm1Dac/Insr^tm1Dac Tg(TTR-INSR)L3Dac/0 involves: 129S4/SvJae * C57BL/6 * FVB	abnormal liver physiology	J:91350
	abnormal pancreatic islet morphology	J:91350
	decreased birth weight	J:91350
	decreased liver glycogen level	J:91350
	decreased white adipose tissue amount	J:91350
	enlarged liver	J:91350
	female infertility	J:91350
	hepatic steatosis	J:91350
	hyperglycemia	J:91350
	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	increased pancreatic beta cell mass	J:91350
	liver degeneration	J:91350
	postnatal growth retardation	J:91350
	premature death	J:91350
Insr^tm1Jja/Insr^tm1Jja Tg(PAH-INSR)1Rjv/0 involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2	abnormal inguinal fat pad morphology	J:80773
	decreased body size	J:80773
	decreased body weight	J:80773
	decreased liver glycogen level	J:80773
	hepatic steatosis	J:80773
	increased circulating glucose level	J:80773
	increased triglyceride level	J:80773
	increased urine glucose level	J:80773
	ketoaciduria	J:80773
	postnatal lethality, complete penetrance	J:80773
Insr^tm1Khn/Insr^tm1Khn Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Pomc1-cre)16Lowl/0 involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N	abnormal gonadal fat pad morphology	J:192274
	absent corpus luteum	J:192274
	absent mature ovarian follicles	J:192274
	decreased lean body mass	J:192274
	decreased ovulation rate	J:192274
	hyperglycemia	J:192274
	increased abdominal adipose tissue amount	J:192274
	increased circulating leptin level	J:192274
	increased fat cell size	J:192274
	increased percent body fat/body weight	J:192274
	liver inflammation	J:192274
	ovary inflammation	J:192274
	white adipose tissue inflammation	J:192274
Insr^tm1Khn/Insr^tm1Khn Pdx1^tm1Ted/Pdx1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S4/SvJae * C57BL/6 * DBA/2	decreased pancreatic beta cell mass	J:92861

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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