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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irf1
interferon regulatory factor 1
MGI:96590
47 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Irf1M1Btlr/Irf1+
C57BL/6J-Irf1M1Btlr 		decreased CD8-positive, alpha-beta T cell number J:162995
decreased NK cell number J:162995
normal hematopoietic system phenotype J:162995
normal immune system phenotype J:162995
impaired natural killer cell mediated cytotoxicity J:162995
increased susceptibility to Herpesvirales infection J:162995
Irf1M1Btlr/Irf1M1Btlr
C57BL/6J-Irf1M1Btlr 		decreased CD8-positive, alpha-beta T cell number J:162995
decreased interferon-alpha secretion J:162995
decreased interferon-beta secretion J:162995
decreased NK cell number J:162995
normal hematopoietic system phenotype J:162995
normal immune system phenotype J:162995
impaired natural killer cell mediated cytotoxicity J:162995
increased susceptibility to Herpesvirales infection J:162995
Irf1m2Btlr/Irf1m2Btlr
C57BL/6J-Irf1m2Btlr 		decreased CD8-positive, alpha-beta T cell number J:267675
decreased NK cell number J:267675
increased B-1 B cell number J:267675
increased CD4-positive, alpha-beta T cell number J:267675
Irf1M3Btlr/Irf1M3Btlr
C57BL/6J-Irf1M3Btlr 		decreased CD8-positive, alpha-beta T cell number J:267677
increased CD4-positive, alpha-beta T cell number J:267677
Irf1tm1Cwe/Irf1tm1Cwe
involves: 129 		abnormal circulating interleukin-4 level J:84367
abnormal circulating interleukin-10 level J:84367
abnormal cytokine level J:84367
abnormal T cell proliferation J:84367
decreased circulating interferon-gamma level J:84367
decreased susceptibility to experimental autoimmune encephalomyelitis J:84367
increased circulating interleukin-5 level J:84367
increased circulating interleukin-6 level J:84367
increased circulating interleukin-13 level J:84367
Irf1tm1Cwe/Irf1tm1Cwe
involves: 129/Sv * C57BL/6 		abnormal cytokine level J:110672
abnormal immune system morphology J:21235
abnormal immune system physiology J:43086
abnormal immunoglobulin level J:101427
abnormal macrophage physiology J:43086
abnormal splenocyte morphology J:21235
abnormal T cell morphology J:21235, J:36025
abnormal thymus cell ratio J:36025
decreased CD8-positive, alpha-beta T cell number J:21235
decreased circulating interleukin-2 level J:110672
decreased susceptibility to induced arthritis J:43086
increased circulating interferon-gamma level J:110672
increased circulating interleukin-3 level J:110672
increased circulating interleukin-4 level J:110672
increased circulating interleukin-5 level J:110672
increased circulating interleukin-6 level J:110672
increased susceptibility to Poxviridae infection J:101427
increased T-helper 2 cell number J:110672
normal skeleton phenotype J:43086
Irf1tm1Mak/Irf1+
either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2) 		no abnormal phenotype detected J:64286
Irf1tm1Mak/Irf1tm1Mak
B6.129S2-Irf1tm1Mak/J 		abnormal circulating alanine transaminase level J:111090
abnormal lymphocyte physiology J:91927
decreased interferon-gamma secretion J:91927
increased incidence of tumors by chemical induction J:91927
increased lymphoma incidence J:91927
increased susceptibility to xenobiotic induced morbidity/mortality J:91927
Irf1tm1Mak/Irf1tm1Mak
either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2) 		abnormal response to infection J:64286
abnormal T cell number J:64286
decreased CD8-positive, alpha-beta T cell number J:64286
normal immune system phenotype J:64286
increased CD4-positive, alpha-beta T cell number J:64286
increased double-positive T cell number J:64286
Irf1tm1Mak/Irf1tm1Mak
involves: 129S2/SvPas 		abnormal DNA repair J:115104
normal cellular phenotype J:115104
Irf1tm1Mak/Irf1tm1Mak
involves: 129S2/SvPas * C57BL/6J 		abnormal vascular wound healing J:118512
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory