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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irf1
interferon regulatory factor 1
MGI:96590
18 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Faslpr/Faslpr
Irf1tm1Mak/Irf1+
MRL.Cg-Irf1tm1Mak Faslpr 		abnormal skin condition J:114771
glomerulonephritis J:114771
normal immune system phenotype J:114771
increased anti-double stranded DNA antibody level J:114771
increased CD4-positive, alpha-beta T cell number J:114771
increased urine protein level J:114771
premature death J:114771
Faslpr/Faslpr
Irf1tm1Mak/Irf1tm1Mak
MRL.Cg-Irf1tm1Mak Faslpr 		abnormal cell physiology J:114771
abnormal cytokine secretion J:114771
decreased anti-double stranded DNA antibody level J:114771
glomerulonephritis J:114771
normal homeostasis/metabolism phenotype J:114771
normal immune system phenotype J:114771
increased CD4-positive, alpha-beta T cell number J:114771
normal integument phenotype J:114771
premature death J:114771
Irf1tm1Mak/Irf1tm1Mak
Miga2tm1a(KOMP)Wtsi/Miga2tm1a(KOMP)Wtsi
B6.Cg-Miga2tm1a(KOMP)Wtsi Irf1tm1Mak 		normal behavior/neurological phenotype J:339075
Irf1tm1Mak/Irf1tm1Mak
Tg(HRAS)2Jic/?
involves: 129S2/SvPas * BALB/c * C57BL/6 		increased hemangiosarcoma incidence J:55418
increased tumor incidence J:55418
Irf1tm1Mak/Irf1tm1Mak
Trp53tm1Sia/Trp53tm1Sia
involves: 129S2/SvPas * C57BL/6 * CBA 		decreased tumor-free survival time J:55418
increased hemangiosarcoma incidence J:55418
increased lymphoma incidence J:55418
increased teratoma incidence J:55418
increased tumor incidence J:55418
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory