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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itga3
integrin alpha 3
MGI:96602
38 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itga3em1(IMPC)Mbp/Itga3em1(IMPC)Mbp
C57BL/6NCrl-Itga3em1(IMPC)Mbp/MbpMmucd 		preweaning lethality, complete penetrance J:211773
Itga3tm1Hap/Itga3tm1Hap
Tg(Mpz-cre)26Mes/0
involves: 129 * C57BL/6 * FVB/NTac 		normal nervous system phenotype J:204174
Itga3tm1Hap/Itga3tm1Hap
Tg(SFTPC-rtTA)5Jaw/?
Tg(tetO-cre)1Jaw/?
involves: 129 * C57BL/6 		decreased lung compliance J:144703
increased type II pneumocyte number J:144703
pulmonary fibrosis J:144703
pulmonary hyperplasia J:144703
thick pulmonary interalveolar septum J:144703
Itga3tm1Jak/Itga3tm1Jak
involves: 129S4/SvJae * C57BL/6J 		abnormal bronchiole epithelium morphology J:36831
abnormal distal convoluted tubule morphology J:36831
abnormal kidney collecting duct morphology J:36831
abnormal podocyte morphology J:36831
abnormal proximal convoluted tubule morphology J:36831
abnormal renal glomerulus basement membrane morphology J:36831
absent podocyte foot process J:36831
decreased glomerular capillary number J:36831
decreased kidney collecting duct number J:36831
dehydration J:36831
dilated glomerular capillary J:36831
impaired branching involved in bronchus morphogenesis J:36831
increased renal glomerulus basement membrane thickness J:36831
kidney cyst J:36831
neonatal lethality, complete penetrance J:36831
small kidney J:36831
Itga3tm1Rdav/Itga3tm1Rdav
Tg(Camk2a-cre)T29-1Stl/0
B6.Cg-Itga3tm1Rdav Tg(Camk2a-cre)T29-1Stl 		impaired spatial working memory J:147820
reduced long-term potentiation J:147820
Itga3tm1Son/Itga3tm1Son
Krt14tm1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * FVB/N 		alopecia J:145988
blistering J:145988
enhanced wound healing J:145988
skin inflammation J:145988
thick skin J:145988
Itga3tm1Son/Itga3tm1Son
Tg(KRT5-cre)5132Jlj/?
involves: 129P2/OlaHsd * C57BL/6 * DBA 		alopecia J:145988
blistering J:145988
skin inflammation J:145988
thick skin J:145988
Itga3tm1Son/Itga3tm1Son
Tg(NPHS2-cre)295Lbh/0
Not Specified 		abnormal renal glomerulus basement membrane morphology J:114988
albuminuria J:114988
dilated proximal convoluted tubule J:114988
edema J:114988
glomerulosclerosis J:114988
increased renal glomerulus basement membrane thickness J:114988
increased urine protein level J:114988
pale kidney J:114988
podocyte foot process effacement J:114988
renal cast J:114988
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory