Itga4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itga4
integrin alpha 4
MGI:96603

26 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itga4^tm1Hyn/Itga4^tm1Hyn either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)	abnormal allantois morphology	J:23140
	abnormal cardiovascular system morphology	J:23140
	abnormal coronary vessel morphology	J:23140
	abnormal craniofacial morphology	J:23140
	abnormal epicardium development	J:23140
	abnormal placenta morphology	J:23140
	dilated allantois	J:23140
	embryonic lethality during organogenesis, incomplete penetrance	J:23140
	failure of chorioallantoic fusion	J:23140
	heart hemorrhage	J:23140
Itga4^tm1Hyn/Itga4^tm1Jty involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N	absent epicardium	J:76747
Itga4^tm1Jty/Itga4^tm1Jty involves: 129S6/SvEvTac * C57BL/6N	abnormal epicardium development	J:76747
	absent epicardium	J:76747
	embryonic lethality during organogenesis, complete penetrance	J:76747
	failure of chorioallantoic fusion	J:76747
	heart hemorrhage	J:76747
Itga4^tm1Mshi/Itga4^tm1Mshi C57BL/6-Itga4^tm1Mshi	abnormal cellular extravasation	J:144092
	abnormal leukocyte adhesion	J:144092
	abnormal leukocyte migration	J:144092
	abnormal mononuclear cell morphology	J:144092
	decreased B cell number	J:144092
	decreased lymphocyte cell number	J:144092
	decreased T cell number	J:144092
	small Peyer's patches	J:144092
Itga4^tm1Tpa/Itga4^tm1Tpa Tg(Mx1-cre)1Cgn/? involves: 129S4/SvJaeSor * C57BL/6 * CBA	abnormal B cell differentiation	J:86861
	abnormal definitive hematopoiesis	J:86861
	abnormal myeloblast morphology/development	J:86861
	abnormal reticulocyte morphology	J:86861
	decreased CD4-positive, alpha-beta T cell number	J:86861
	increased leukocyte cell number	J:86861

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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