Itga6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itga6
integrin alpha 6
MGI:96605

27 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itga6^{Gt(LST045)Byg}/Itga6^{Gt(LST045)Byg} involves: 129P2/OlaHsd	normal hearing/vestibular/ear phenotype	J:142510
Itga6^tm1Egl/Itga6^tm1Egl either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)	abnormal brain morphology	J:79739
	abnormal mouth morphology	J:33712
	abnormal neuronal precursor cell migration	J:79739
	abnormal retina nerve fiber layer morphology	J:79739
	abnormal skin condition	J:33712
	abnormal vitreous body morphology	J:79739
	disorganized cortical plate	J:79739
	perinatal lethality, complete penetrance	J:33712
Itga6^tm1Egl/Itga6^tm1Egl involves: 129S2/SvPas * C57BL/6	abnormal basement membrane morphology	J:119018
Itga6^tm1Egl/Itga6^tm1Egl involves: 129S2/SvPas * C57BL/6	abnormal cerebral cortex morphology	J:119018
Itga6^tm1Son/Itga6^tm1Son involves: 129P2/OlaHsd * FVB	abnormal lymph node morphology	J:50235
	abnormal T cell physiology	J:50235
	decreased T cell number	J:50235
Itga6^tm2.1Egl/Itga6^tm2.1Egl involves: C57BL/6	blistering	J:204174
Itga6^tm2.1Egl/Itga6^tm2.1Egl involves: C57BL/6	perinatal lethality, complete penetrance	J:204174
Itga6^tm2Egl/Itga6^tm2Egl Tg(Mpz-cre)26Mes/0 involves: C57BL/6 * FVB/NTac	abnormal axon morphology	J:204174
	abnormal myelination	J:204174
	abnormal Schwann cell physiology	J:204174
	abnormal sciatic nerve morphology	J:204174
	axon degeneration	J:204174
	decreased myelin sheath thickness	J:204174
	hypermyelination	J:204174
	increased myelin sheath thickness	J:204174
	normal mortality/aging	J:204174
Itga6^tm2Egl/Itga6^tm2Egl Tg(Tie1-cre)9Ref/0 involves: 129S1/Sv * 129X1/SvJ	abnormal tumor vascularization	J:156496
	increased angiogenesis	J:156496
	increased tumor growth/size	J:156496

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24