Itga6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itga6
integrin alpha 6
MGI:96605

27 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itga6^{Gt(LST045)Byg}/Itga6^{Gt(LST045)Byg} involves: 129P2/OlaHsd	normal hearing/vestibular/ear phenotype	J:142510
Itga6^tm1Egl/Itga6^tm1Egl either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * C57BL/6 * CD-1)	abnormal brain morphology	J:79739
	abnormal mouth morphology	J:33712
	abnormal neuronal precursor cell migration	J:79739
	abnormal retina nerve fiber layer morphology	J:79739
	abnormal skin condition	J:33712
	abnormal vitreous body morphology	J:79739
	disorganized cortical plate	J:79739
	perinatal lethality, complete penetrance	J:33712
Itga6^tm1Egl/Itga6^tm1Egl involves: 129S2/SvPas * C57BL/6	abnormal basement membrane morphology	J:119018
Itga6^tm1Egl/Itga6^tm1Egl involves: 129S2/SvPas * C57BL/6	abnormal cerebral cortex morphology	J:119018
Itga6^tm1Son/Itga6^tm1Son involves: 129P2/OlaHsd * FVB	abnormal lymph node morphology	J:50235
	abnormal T cell physiology	J:50235
	decreased T cell number	J:50235
Itga6^tm2.1Egl/Itga6^tm2.1Egl involves: C57BL/6	blistering	J:204174
Itga6^tm2.1Egl/Itga6^tm2.1Egl involves: C57BL/6	perinatal lethality, complete penetrance	J:204174
Itga6^tm2Egl/Itga6^tm2Egl Tg(Mpz-cre)26Mes/0 involves: C57BL/6 * FVB/NTac	abnormal axon morphology	J:204174
	abnormal myelination	J:204174
	abnormal Schwann cell physiology	J:204174
	abnormal sciatic nerve morphology	J:204174
	axon degeneration	J:204174
	decreased myelin sheath thickness	J:204174
	hypermyelination	J:204174
	increased myelin sheath thickness	J:204174
	normal mortality/aging	J:204174
Itga6^tm2Egl/Itga6^tm2Egl Tg(Tie1-cre)9Ref/0 involves: 129S1/Sv * 129X1/SvJ	abnormal tumor vascularization	J:156496
	increased angiogenesis	J:156496
	increased tumor growth/size	J:156496

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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