Itgal Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itgal
integrin alpha L
MGI:96606

42 phenotypes from 7 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itgal^em1(IMPC)H/Itgal^em1(IMPC)H C57BL/6NTac-Itgal^em1(IMPC)H/H	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
Itgal^tm1.1Mshi/Itgal^tm1.1Mshi involves: C57BL/6	abnormal diapedesis	J:168533
	abnormal leukocyte adhesion	J:168533
	abnormal leukocyte migration	J:168533
	decreased lymphocyte cell number	J:168533
	enhanced leukocyte tethering or rolling	J:168533
	small lymph nodes	J:168533
Itgal^tm1Bll/Itgal⁺ involves: 129S7/SvEvBrd	abnormal CD4-positive, alpha-beta T cell physiology	J:267548
Itgal^tm1Bll/Itgal^tm1Bll B6.129S7-Itgal^tm1Bll	abnormal leukocyte adhesion	J:100242
	abnormal leukocyte tethering or rolling	J:100242
	decreased T cell proliferation	J:90954
	impaired natural killer cell mediated cytotoxicity	J:90954
	increased leukocyte cell number	J:100242
	increased neutrophil cell number	J:100242
Itgal^tm1Bll/Itgal^tm1Bll B6.129S7-Itgal^tm1Bll/J	abnormal inflammatory response	J:113463
Itgal^tm1Bll/Itgal^tm1Bll involves: 129S7/SvEvBrd	abnormal CD4-positive, alpha-beta T cell physiology	J:267548
	abnormal cellular extravasation	J:141063
	abnormal leukocyte adhesion	J:141063
	abnormal neutrophil physiology	J:141063
Itgal^tm1Bll/Itgal^tm1Bll involves: 129S7/SvEvBrd * C57BL/6J	abnormal cellular extravasation	J:83226
	abnormal leukocyte adhesion	J:83226
	abnormal leukocyte migration	J:83226
	increased eosinophil cell number	J:83226
	increased leukocyte cell number	J:83226
	increased monocyte cell number	J:83226
	increased neutrophil cell number	J:83226
Itgal^tm1Hlz/Itgal^tm1Hlz involves: 129P2/OlaHsd	abnormal cellular extravasation	J:99286
	abnormal humoral immune response	J:99286
	abnormal leukocyte adhesion	J:99286
	abnormal T cell activation	J:99286
	decreased cytotoxic T cell cytolysis	J:99286
	decreased lymphocyte cell number	J:99286
	decreased neutrophil cell number	J:99286
	spleen hyperplasia	J:99286
Itgal^tm1Hogg/Itgal^tm1Hogg involves: 129P2/OlaHsd	abnormal leukocyte adhesion	J:82587
	abnormal leukocyte migration	J:82587
	abnormal lymph node morphology	J:82587
	decreased B cell number	J:82587
	decreased CD4-positive, alpha-beta T cell number	J:82587
	decreased CD8-positive, alpha-beta T cell number	J:82587
	decreased lymphocyte cell number	J:82587
	enlarged spleen	J:82587
	increased CD4-positive, alpha-beta T cell number	J:82587
	increased CD8-positive, alpha-beta T cell number	J:82587
	small lymph nodes	J:82587
Itgal^tm1Mak/Itgal⁺ B6.129P2-Itgal^tm1Mak	decreased susceptibility to endotoxin shock	J:123460
Itgal^tm1Mak/Itgal^tm1Mak B6.129P2-Itgal^tm1Mak	decreased susceptibility to endotoxin shock	J:123460
	impaired natural killer cell mediated cytotoxicity	J:110889
	increased circulating interleukin-2 level	J:123460
	increased circulating interleukin-10 level	J:123460
	increased circulating tumor necrosis factor level	J:123460
	thrombocytopenia	J:123460
Itgal^tm1Wpfl/Itgal^tm1Wpfl involves: 129	abnormal cytotoxic T cell physiology	J:37160
	abnormal leukocyte physiology	J:37160
	abnormal lymphocyte physiology	J:37160
	normal immune system phenotype	J:37160
	increased metastatic potential	J:37160
	lymph node hyperplasia	J:37160

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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