Itgam Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itgam
integrin alpha M
MGI:96607

31 phenotypes from 7 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itgam^{em1(IMPC)Wtsi}/Itgam^{em1(IMPC)Wtsi} C57BL/6N-Itgam^{em1(IMPC)Wtsi}/Wtsi	increased mean corpuscular hemoglobin	J:211773
Itgam^m1Btlr/Itgam⁺ C57BL/6J-Itgam^m1Btlr	abnormal dendritic cell number	J:236681
	decreased macrophage cell number	J:236681
	decreased neutrophil cell number	J:236681
	impaired hematopoiesis	J:236681
	increased plasmacytoid dendritic cell number	J:236681
Itgam^m1Btlr/Itgam^m1Btlr C57BL/6J-Itgam^m1Btlr	abnormal dendritic cell number	J:236681
	decreased macrophage cell number	J:236681
	decreased neutrophil cell number	J:236681
	impaired hematopoiesis	J:236681
	increased plasmacytoid dendritic cell number	J:236681
Itgam^m2Btlr/Itgam^m2Btlr C57BL/6J-Itgam^m2Btlr	decreased CD11b-high dendritic cell number	J:272532
Itgam^m3Btlr/Itgam^m3Btlr C57BL/6J-Itgam^m3Btlr	decreased CD11b-high dendritic cell number	J:272533
Itgam^tm1Bll/Itgam^tm1Bll B6.129S7-Itgam^tm1Bll	abnormal leukocyte adhesion	J:100242
	abnormal lymphocyte cell number	J:90954
	abnormal T cell activation	J:90954
	abnormal T cell subpopulation ratio	J:90954
	decreased CD4-positive, alpha-beta T cell number	J:90954
	decreased T cell proliferation	J:90954
	increased CD8-positive, alpha-beta T cell number	J:90954
	increased leukocyte cell number	J:100242
	increased neutrophil cell number	J:100242
	increased susceptibility to bacterial infection	J:94855
Itgam^tm1Bll/Itgam^tm1Bll involves: 129S7/SvEvBrd * C57BL/6J	abnormal cellular extravasation	J:83226
	abnormal leukocyte adhesion	J:83226
	abnormal leukocyte migration	J:83226
	abnormal neutrophil physiology	J:39092
	decreased eosinophil cell number	J:83226
	impaired neutrophil phagocytosis	J:39092
Itgam^tm1Myd/Itgam^tm1Myd B6.129S4-Itgam^tm1Myd	abnormal blood homeostasis	J:113463
	abnormal inflammatory response	J:113463
	abnormal neutrophil morphology	J:113463
	abnormal neutrophil physiology	J:113463
Itgam^tm1Myd/Itgam^tm1Myd involves: 129S4/SvJae	impaired leukocyte tethering or rolling	J:198197
Itgam^tm1Myd/Itgam^tm1Myd involves: 129S4/SvJae	impaired neutrophil phagocytosis	J:155479
Itgam^tm1Myd/Itgam^tm1Myd involves: 129S4/SvJae * BALB/c * C57BL/6	abnormal leukocyte adhesion	J:38052
	decreased apoptosis	J:38052
	impaired neutrophil phagocytosis	J:38052
	increased eosinophil cell number	J:38052
	increased neutrophil cell number	J:38052
Itgam^tm1Myd/Itgam^tm1Myd involves: 129S4/SvJae * C57BL/6	decreased cerebral infarct size	J:103873
Itgam^tm1Myd/Itgam^tm1Myd involves: 129S4/SvJae * C57BL/6	decreased neutrophil cell number	J:103873
Itgam^tm1Rws/Itgam^tm1Rws involves: 129P2/OlaHsd * C57BL/6J	abnormal cell adhesion	J:65847
Itgam^tm1Rws/Itgam^tm1Rws involves: 129P2/OlaHsd * C57BL/6J	abnormal macrophage physiology	J:65847

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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