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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itgax
integrin alpha X
MGI:96609
12 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
ItgaxM1Btlr/Itgax+
C57BL/6J-ItgaxM1Btlr 		decreased dendritic cell number J:236684
impaired hematopoiesis J:236684
increased plasmacytoid dendritic cell number J:236684
ItgaxM1Btlr/ItgaxM1Btlr
C57BL/6J-ItgaxM1Btlr 		decreased dendritic cell number J:236684
impaired hematopoiesis J:236684
increased plasmacytoid dendritic cell number J:236684
Itgaxtm1Bll/Itgaxtm1Bll
B6.129S7-Itgaxtm1Bll 		decreased interferon-gamma secretion J:122187
decreased interleukin-17 secretion J:122187
decreased susceptibility to experimental autoimmune encephalomyelitis J:122187
decreased tumor necrosis factor secretion J:122187
increased interleukin-2 secretion J:122187
increased interleukin-12 secretion J:122187
increased susceptibility to bacterial infection J:94855
increased T cell proliferation J:122187
Itgaxtm1Bll/Itgaxtm1Bll
involves: 129S7/SvEvBrd 		no abnormal phenotype detected J:90954
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory