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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itgb1
integrin beta 1 (fibronectin receptor beta)
MGI:96610
258 phenotypes from 25 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itgb1em1(IMPC)Bay/Itgb1+
C57BL/6N-Itgb1em1(IMPC)Bay/BayMmucd 		hyperactivity J:211773
Itgb1em1(IMPC)Bay/Itgb1em1(IMPC)Bay
C57BL/6N-Itgb1em1(IMPC)Bay/BayMmucd 		preweaning lethality, complete penetrance J:211773
Itgb1tm1.1Efu/Itgb1tm1.1Efu
involves: 129X1/SvJ 		absent inner cell mass J:108331
embryonic lethality between implantation and somite formation, complete penetrance J:108331
Itgb1tm1Efu/Itgb1tm1Efu
Tg(ATP6V1B1-cre)45Rnel/0
involves: 129X1/SvJ * C57BL/6 		abnormal kidney cortex morphology J:167156
decreased circulating bicarbonate level J:167156
normal hearing/vestibular/ear phenotype J:167156
increased urine pH J:167156
metabolic acidosis J:167156
renal tubular acidosis J:167156
Itgb1tm1Efu/Itgb1tm1Efu
Tg(Cryaa-cre)10Mlr/?
involves: 129X1/SvJ * C57BL/6 		abnormal lens epithelium morphology J:122566
abnormal lens fiber morphology J:122566
aphakia J:122566
microphthalmia J:122566
Itgb1tm1Efu/Itgb1tm1Efu
Tg(KRT14-cre)1Efu/0
involves: 129X1/SvJ 		abnormal basement membrane morphology J:65039
abnormal epidermal layer morphology J:65039
abnormal epidermis stratum basale morphology J:65039
abnormal hair follicle development J:65039
abnormal skin condition J:65039
blistering J:65039
decreased hair follicle number J:65039
dermal-epidermal separation J:65039
neonatal lethality, incomplete penetrance J:65039
thin epidermis J:65039
thin skin J:65039
Itgb1tm1Efu/Itgb1tm1Efu
Tg(NPHS2-cre)295Lbh/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal glomerular capillary morphology J:135414
abnormal kidney morphology J:135414
abnormal renal glomerular capsule morphology J:135414
abnormal renal glomerulus basement membrane morphology J:135414
abnormal renal glomerulus morphology J:135414
abnormal renal tubule epithelium morphology J:135414
albuminuria J:135414
decreased body size J:135414
decreased locomotor activity J:135414
dilated glomerular capillary J:135414
dilated renal tubule J:135414
edema J:135414
expanded mesangial matrix J:135414
increased mesangial cell number J:135414
increased podocyte apoptosis J:135414
increased urine protein level J:135414
mesangiolysis J:135414
pale kidney J:135414
podocyte foot process effacement J:135414
premature death J:135414
renal cast J:135414
small kidney J:135414
Itgb1tm1Efu/Itgb1tm1Efu
Tg(Vil1-cre)997Gum/0
involves: 129X1/SvJ * C57BL/6J * SJL 		abnormal circulating lipid level J:119155
abnormal crypts of Lieberkuhn morphology J:119155
abnormal enterocyte morphology J:119155
abnormal intestinal absorption J:119155
abnormal intestinal epithelium morphology J:119155
abnormal intestine morphology J:119155
abnormal large intestine morphology J:119155
abnormal small intestine morphology J:119155
decreased body weight J:119155
intestine polyps J:119155
postnatal lethality, complete penetrance J:119155
steatorrhea J:119155
Itgb1tm1Lscd/Itgb1tm1Lscd
involves: 129X1/SvJ * Black Swiss 		abnormal blastocoele morphology J:28266
abnormal inner cell mass morphology J:28266
abnormal trophoblast layer morphology J:28266
abnormal visceral endoderm morphology J:28266
embryonic lethality between implantation and somite formation, complete penetrance J:28266
inner cell mass degeneration J:28266
Itgb1tm1Lscd/Itgb1tm1Mll
Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal Cajal-Retzius cell morphology J:71122
abnormal cerebellar foliation J:71122
abnormal cerebellum development J:71122
abnormal cerebellum morphology J:71122
abnormal cerebellum vermis morphology J:71122
abnormal cerebral cortex morphology J:71122
abnormal CNS glial cell morphology J:71122
abnormal cortical marginal zone morphology J:71122
abnormal eyelid morphology J:71122
abnormal meninges morphology J:71122
ataxia J:71122
neonatal lethality, complete penetrance J:71122
postnatal growth retardation J:71122
premature death J:71122
small cerebellum J:71122
Itgb1tm1Lscd/Itgb1tm1Ref
Tg(PLAT-cre)116Sdu/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal enteric neural crest cell migration J:108439
abnormal enteric neural crest cell morphology J:108439
abnormal enteric neuron morphology J:108439
abnormal innervation J:108439
abnormal neuronal migration J:108439
aganglionic megacolon J:108439
Itgb1tm1Lscd/Itgb1tm1Ref
Tg(PLAT-cre)116Sdu/0
Not Specified 		abnormal cranial nerve morphology J:92060
abnormal innervation pattern to muscle J:92060
abnormal motor coordination/balance J:92060
abnormal myelination J:92060
abnormal nervous system morphology J:92060
abnormal neuromuscular synapse morphology J:92060
abnormal sciatic nerve morphology J:92060
absent Schwann cell precursors J:92060
muscular atrophy J:92060
premature death J:92060
progressive muscle weakness J:92060
Itgb1tm1Mlkn/Itgb1tm1Mlkn
involves: 129/Sv * C57BL/6 * SJL 		absent inner cell mass J:108331
embryonic lethality between implantation and somite formation, complete penetrance J:108331
Itgb1tm1Mll/Itgb1tm1Mll
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * 129X1/SvJ 		abnormal Cajal-Retzius cell morphology J:170581
abnormal radial glial cell morphology J:170581
normal nervous system phenotype J:170581
radial glial endfoot detachment J:170581
Itgb1tm1Mll/Itgb1tm1Mll
Tg(MMTV-cre)7Mul/0
involves: 129X1/SvJ * FVB/N 		normal endocrine/exocrine gland phenotype J:92547
Itgb1tm1Mll/Itgb1tm1Mll
Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal neuronal precursor cell migration J:120076
abnormal rostral migratory stream morphology J:120076
small olfactory bulb J:120076
Itgb1tm1Mll/Itgb1tm1Mll
Tg(Wap-cre)1Gsc/0
involves: 129X1/SvJ * FVB/N 		abnormal mammary gland growth during lactation J:99405
abnormal mammary gland morphology J:99405
Itgb1tm1Mll/Itgb1tm1Mll
Wnt3atm1(cre)Eag/Wnt3a+
involves: 129X1/SvJ 		normal nervous system phenotype J:170581
Itgb1tm1Ref/Itgb1tm1Ref
Tg(Col2a1-cre)1Asz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal bone mineralization J:85994
abnormal bone ossification J:85994
abnormal cartilage development J:85994
abnormal chondrocyte morphology J:85994
abnormal long bone epiphyseal plate morphology J:85994
abnormal long bone hypertrophic chondrocyte zone J:85994
chondrodystrophy J:85994
cleft palate J:85994
decreased body length J:85994
decreased chondrocyte number J:85994
decreased chondrocyte proliferation J:85994
decreased length of long bones J:85994
disproportionate dwarf J:85994
increased chondrocyte apoptosis J:85994
increased diameter of long bones J:85994
neonatal lethality, complete penetrance J:85994
respiratory distress J:85994
short humerus J:85994
short tibia J:85994
Itgb1tm1Ref/Itgb1tm1Ref
Tg(Ins2-cre)1Heed/?
involves: 129 * C57BL/6 * CBA 		disorganized pancreatic islets J:122649
increased pancreatic alpha cell number J:122649
Itgb1tm1Ref/Itgb1tm1Ref
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J 		abnormal dermal layer morphology J:65038, J:148885
abnormal dermal pigmentation J:148885
abnormal ear position J:65038
abnormal ear shape J:65038
abnormal epidermal-dermal junction morphology J:65038, J:148885
abnormal epidermis stratum basale morphology J:65038
abnormal esophageal epithelium morphology J:65038
abnormal gait J:65038
abnormal hair follicle morphology J:65038, J:148885, J:177979
abnormal hair growth J:177979
abnormal keratinocyte morphology J:65038
absent sebaceous gland J:65038
alopecia J:65038
blistering J:65038, J:148885, J:177979
decreased body weight J:65038
decreased hair follicle cell proliferation J:65038
decreased hair follicle number J:65038, J:177979
epidermal hyperplasia J:148885
hypopigmentation J:65038
impaired skin barrier function J:65038
infertility J:148885
perianal ulcer J:65038
premature death J:65038
progressive hair loss J:148885
reddish skin J:65038, J:177979
skin inflammation J:65038
skin lesions J:65038
thick epidermis J:65038, J:177979
tight skin J:65038
Itgb1tm1Ref/Itgb1tm1Ref
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal platelet physiology J:118488
decreased platelet calcium level J:118488
Itgb1tm1Ref/Itgb1tm2Ref
Tg(Col2a1-cre)1Asz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal bone mineralization J:85994
abnormal bone ossification J:85994
abnormal cartilage development J:85994
abnormal chondrocyte morphology J:85994
abnormal long bone epiphyseal plate morphology J:85994
abnormal long bone hypertrophic chondrocyte zone J:85994
chondrodystrophy J:85994
cleft palate J:85994
decreased body length J:85994
decreased chondrocyte number J:85994
decreased chondrocyte proliferation J:85994
decreased length of long bones J:85994
disproportionate dwarf J:85994
increased chondrocyte apoptosis J:85994
increased diameter of long bones J:85994
neonatal lethality, complete penetrance J:85994
respiratory distress J:85994
short humerus J:85994
short tibia J:85994
Itgb1tm1Ref/Itgb1tm5.1Ref
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J 		abnormal coat/ hair morphology J:177979
abnormal dermal layer morphology J:148885
abnormal dermal pigmentation J:148885
abnormal hair follicle morphology J:148885, J:177979
abnormal hair follicle outer root sheath morphology J:148885
abnormal hair growth J:177979
blistering J:148885
decreased hair follicle number J:177979
decreased keratinocyte proliferation J:148885
progressive hair loss J:148885
normal reproductive system phenotype J:148885
sparse hair J:148885
Itgb1tm1Ref/Itgb1tm12.1Ref
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J 		abnormal hair follicle development J:177979
abnormal hair follicle morphology J:177979
abnormal hair growth J:177979
abnormal skin pigmentation J:177979
alopecia J:177979
blistering J:177979
decreased hair follicle number J:177979
decreased keratinocyte adhesion J:177979, J:203018
enlarged hair follicles J:203018
reddish skin J:177979
skin lesions J:177979
sparse hair J:203018
thick epidermis J:177979
Itgb1tm1Ref/Itgb1tm14.1Ref
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J 		abnormal epidermal layer morphology J:203018
abnormal hair growth J:203018
decreased keratinocyte migration J:203018
delayed wound healing J:203018
normal integument phenotype J:203018
Itgb1tm1Ref/Itgb1tm15.1Ref
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J 		abnormal epidermal layer morphology J:203018
abnormal hair growth J:203018
decreased keratinocyte adhesion J:203018
decreased keratinocyte proliferation J:203018
enlarged hair follicles J:203018
Itgb1tm1Ross/Itgb1tm1Ross
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss 		abnormal atrial thrombosis J:82534
abnormal cardiac muscle cell glucose uptake J:82534
abnormal cardiac muscle relaxation J:82534
abnormal heart ventricle morphology J:82534
abnormal myocardial fiber morphology J:82534
abnormal myocardium layer morphology J:82534
cardiac fibrosis J:82534
congestive heart failure J:82534
decreased heart left ventricle muscle contractility J:82534
dilated cardiomyopathy J:82534
dilated heart J:82534
dilated heart left ventricle J:82534
dilated heart right ventricle J:82534
increased heart atrium size J:82534
increased response of heart to induced stress J:82534
increased susceptibility to induced morbidity/mortality J:82534
liver vascular congestion J:82534
pleural effusion J:82534
thick ventricular wall J:82534
Itgb1tm1Ross/Itgb1tm1Ross
Tg(Hoxb7-cre)13Amc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal kidney collecting duct morphology J:149831
abnormal kidney cortex morphology J:149831
abnormal kidney medulla morphology J:149831
abnormal kidney morphology J:149831
abnormal renal filtration rate J:149831
abnormal renal transport J:149831
abnormal urine homeostasis J:149831
absent kidney J:149831
decreased hematocrit J:149831
decreased kidney weight J:149831
decreased urine osmolality J:149831
dilated kidney collecting duct J:149831
increased blood urea nitrogen level J:149831
increased kidney apoptosis J:149831
increased kidney cell proliferation J:149831
isosthenuria J:149831
kidney failure J:149831
kidney medulla cyst J:149831
kidney medulla hypoplasia J:149831
polyuria J:149831
preweaning lethality, incomplete penetrance J:149831
renal hypoplasia J:149831
single kidney J:149831
small kidney J:149831
Itgb1tm1Son/Itgb1tm1Son
either: 129P2/OlaHsd-Itgb1tm1Son or (involves: 129P2/OlaHsd * FVB) 		abnormal cardiovascular system physiology J:47279
normal muscle phenotype J:47279
Itgb1tm2Mlkn/Itgb1tm2Mlkn
involves: 129/Sv * C57BL/6 * SJL 		abnormal platelet physiology J:108331
Itgb1tm2Son/Itgb1tm2Son
either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB) 		abnormal brain morphology J:47279
abnormal cell adhesion J:47279
abnormal choroid plexus morphology J:47279
abnormal craniofacial morphology J:82463
abnormal digit development J:47279
abnormal eye distance/ position J:47279
abnormal facial morphology J:47279
abnormal first pharyngeal arch morphology J:47279
abnormal head morphology J:47279
abnormal left-right axis patterning J:47279
abnormal limb morphology J:47279
abnormal nervous system morphology J:82463
abnormal neural tube morphology J:47279
anemia J:47279
decreased fibroblast cell migration J:47279
decreased hindbrain size J:47279
embryonic lethality during organogenesis, incomplete penetrance J:47279, J:82463
hemorrhage J:47279, J:82463
increased embryonic neuroepithelium thickness J:47279
kinked neural tube J:47279
lethality throughout fetal growth and development, complete penetrance J:47279
mandible hypoplasia J:47279
micrognathia J:47279
small first pharyngeal arch J:47279
small second pharyngeal arch J:47279
spina bifida J:47279
wavy neural tube J:47279
Itgb1tm2Son/Itgb1tm2Son
FVB.129P2-Itgb1tm2Son 		abnormal craniofacial morphology J:82463
abnormal head morphology J:82463
abnormal limb morphology J:82463
abnormal myogenesis J:82463
abnormal myotube morphology J:82463
abnormal nervous system morphology J:82463
abnormal pharyngeal arch morphology J:82463
abnormal placenta labyrinth morphology J:82463
abnormal placenta morphology J:82463
abnormal placental labyrinth vasculature morphology J:82463
abnormal posture J:82463
abnormal skeletal muscle morphology J:82463
abnormal spine curvature J:82463
normal cardiovascular system phenotype J:82463
cyanosis J:82463
decreased body length J:82463
decreased body weight J:82463
decreased fetal size J:82463
decreased skeletal muscle fiber number J:82463
decreased skeletal muscle mass J:82463
embryonic growth arrest J:82463
embryonic lethality during organogenesis, incomplete penetrance J:82463
kinked neural tube J:82463
open neural tube J:82463
pallor J:82463
perinatal lethality, incomplete penetrance J:82463
Itgb1tm3Mlkn/Itgb1tm3Mlkn
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA 		decreased circulating noradrenaline level J:108331
Itgb1tm3Ref/Itgb1tm3Ref
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality before implantation, complete penetrance J:28330
Itgb1tm5.1Ref/Itgb1tm5.1Ref
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality between implantation and somite formation, complete penetrance J:148885
preweaning lethality, complete penetrance J:177979
Itgb1tm6.1Ref/Itgb1tm6.1Ref
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:177979
Itgb1tm7.1Ref/Itgb1tm7.1Ref
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:177979
Itgb1tm8.1Ref/Itgb1tm8.1Ref
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:177979
Itgb1tm9.1Ref/Itgb1tm9.1Ref
involves: 129S1/Sv * 129X1/SvJ 		normal integument phenotype J:176453
normal neoplasm J:176453
no abnormal phenotype detected J:177979
Itgb1tm9.1Ref/Itgb1tm10.1Ref
involves: 129S1/Sv * 129X1/SvJ 		normal integument phenotype J:176453
normal neoplasm J:176453
no abnormal phenotype detected J:177979
Itgb1tm10.1Ref/Itgb1tm10.1Ref
involves: 129S1/Sv * 129X1/SvJ 		abnormal embryo development J:185558
lethality, complete penetrance J:185558
Itgb1tm11.1Ref/Itgb1tm11.1Ref
involves: 129S1/Sv * 129X1/SvJ 		decreased incidence of tumors by chemical induction J:176453
decreased keratinocyte adhesion J:176453
normal integument phenotype J:177979
Itgb1tm12.1Ref/Itgb1tm12.1Ref
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality, complete penetrance J:177979
Itgb1tm13.1Ref/Itgb1tm13.1Ref
involves: 129S1/Sv * 129X1/SvJ 		abnormal embryo development J:185558
abnormal embryo implantation J:185558
absent blastocoele J:185558
embryonic lethality, incomplete penetrance J:185558
lethality, complete penetrance J:185558
Itgb1tm14.1Ref/Itgb1tm14.1Ref
Not Specified 		abnormal cell physiology J:203018
embryonic lethality, complete penetrance J:203018
lethality, complete penetrance J:185558
Itgb1tm14.1Ref/Itgb1tm15.1Ref
Not Specified 		abnormal cell physiology J:203018
embryonic lethality, complete penetrance J:203018
Itgb1tm15.1Ref/Itgb1tm15.1Ref
Not Specified 		abnormal cell physiology J:203018
embryonic lethality, complete penetrance J:203018
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory