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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itgb2
integrin beta 2
MGI:96611
99 phenotypes from 9 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itgb2M1Btlr/Itgb2M1Btlr
C57BL/6J-Itgb2M1Btlr 		abnormal NK cell differentiation J:139559
decreased interferon-gamma secretion J:139559
normal immune system phenotype J:139559
Itgb2m2Btlr/Itgb2m2Btlr
C57BL/6J-Itgb2m2Btlr 		increased interferon-beta secretion J:265125
Itgb2m3Btlr/Itgb2m3Btlr
C57BL/6J-Itgb2m3Btlr 		abnormal cytotoxic T cell cytolysis J:265126
decreased B cell number J:265126
decreased CD4-positive, alpha-beta T cell number J:265126
decreased CD8-positive, alpha-beta T cell number J:265126
decreased dendritic cell number J:265126
decreased IgG level J:265126
decreased macrophage cell number J:265126
decreased neutrophil cell number J:265126
decreased single-positive T cell number J:265126
impaired humoral immune response J:265126
impaired natural killer cell mediated cytotoxicity J:265126
increased dendritic cell number J:265126
increased effector memory CD4-positive, alpha-beta T cell number J:265126
increased IgE level J:265126
increased NK T cell number J:265126
Itgb2M4Btlr/Itgb2M4Btlr
C57BL/6J-Itgb2M4Btlr 		abnormal T cell differentiation J:272843
increased effector memory CD4-positive, alpha-beta T cell number J:272843
Itgb2m5Btlr/Itgb2m5Btlr
C57BL/6J-Itgb2m5Btlr 		increased B-1b cell number J:272844
Itgb2tm1.1Arte/Itgb2tm1.1Arte
involves: C57BL/6NTac 		abnormal T cell physiology J:202261
decreased T cell proliferation J:202261
enlarged spleen J:202261
increased B cell number J:202261
increased dendritic cell number J:202261
increased neutrophil cell number J:202261
increased T cell number J:202261
lymph node hypoplasia J:202261
Itgb2tm1.1Mskim/Itgb2tm1.1Mskim
B6.129S6-Itgb2tm1.1Mskim 		no abnormal phenotype detected J:184820
Itgb2tm1Bay/Itgb2tm1Bay
B6.129S7-Itgb2tm1Bay/J 		abnormal eye physiology J:118466
abnormal retina morphology J:118466, J:119416
abnormal retina vasculature morphology J:118466
decreased susceptibility to induced choroidal neovascularization J:119416
increased circulating glucose level J:118466
premature death J:118466
Itgb2tm1Bay/Itgb2tm1Bay
involves: 129S7/SvEvBrd 		decreased inflammatory response J:13599
increased granulocyte number J:13599
increased leukocyte cell number J:13599, J:32126
increased lymphocyte cell number J:13599
normal integument phenotype J:32126
Itgb2tm1Bay/Itgb2tm1Bay
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal spleen red pulp morphology J:13599
normal integument phenotype J:32126
myeloid hyperplasia J:13599
Itgb2tm1Bay/Itgb2tm1Bay
involves: 129S7/SvEvBrd * C57BL/6J * PL/J 		alopecia J:84126
dermatitis J:84126
normal integument phenotype J:32126, J:84126
psoriasis J:84126
reddish skin J:84126
Itgb2tm1Bay/Itgb2tm1Bay
involves: 129S7/SvEvBrd * PL/J 		abnormal cytokine level J:109598
abnormal dermal layer morphology J:32126
abnormal epidermal layer morphology J:32126
abnormal hair follicle dermal papilla morphology J:32126
abnormal skin condition J:32126
abnormal spleen morphology J:32126
abnormal T cell activation J:109598
alopecia J:32126, J:109598
dermatitis J:32126, J:109598
enlarged lymph nodes J:32126
epidermal hyperplasia J:32126
increased basophil cell number J:32126
increased eosinophil cell number J:32126
increased interferon-gamma secretion J:109598
increased leukocyte cell number J:32126
increased lymphocyte cell number J:32126
increased monocyte cell number J:32126
increased neutrophil cell number J:32126
increased T cell number J:109598
increased T-helper 1 cell number J:109598
normal integument phenotype J:32126
mixed cellular infiltration to dermis J:32126
myeloid hyperplasia J:32126
orthokeratosis J:32126
parakeratosis J:32126
normal pigmentation phenotype J:32126
psoriasis J:32126, J:109598
reddish skin J:32126
scaly skin J:32126, J:109598
thrombocytosis J:32126
Itgb2tm1Bay/Itgb2tm2Bay
B6.129S7-Itgb2tm1Bay Itgb2tm2Bay 		normal integument phenotype J:84126
Itgb2tm1Bay/Itgb2tm2Bay
involves: 129S7/SvEvBrd * C57BL/6J * PL/J 		abnormal skin condition J:84126
acanthosis J:84126
dermatitis J:84126
hyperkeratosis J:84126
psoriasis J:84126
Itgb2tm1Bay/Itgb2tm2Bay
PL.129S7-Itgb2tm1Bay Itgb2tm2Bay 		abnormal skin condition J:84126
acanthosis J:84126
dermatitis J:84126
orthokeratosis J:84126
parakeratosis J:84126
psoriasis J:84126
Itgb2tm2Bay/Itgb2tm2Bay
B6.129S7-Itgb2tm2Bay 		abnormal bone structure J:101407
abnormal leukocyte adhesion J:83226
abnormal leukocyte migration J:83226
abnormal long bone metaphysis morphology J:101407
decreased bone mineral density of femur J:101407
decreased bone mineralization J:101407
decreased bone ossification J:101407
decreased susceptibility to bacterial infection J:94855
decreased trabecular bone mass J:101407
increased eosinophil cell number J:83226
increased leukocyte cell number J:83226
increased lymphocyte cell number J:83226
increased monocyte cell number J:83226
increased neutrophil cell number J:83226
osteoporosis J:101407
Itgb2tm2Bay/Itgb2tm2Bay
involves: 129S7/SvEvBrd 		decreased T cell proliferation J:90954
Itgb2tm2Bay/Itgb2tm2Bay
involves: 129S7/SvEvBrd * C57BL/6 		decreased acute inflammation J:112286
impaired neutrophil recruitment J:112286
increased neutrophil cell number J:112286
spontaneous skin ulceration J:112286
Itgb2tm2Bay/Itgb2tm2Bay
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal immune system cell morphology J:48542
abnormal leukocyte physiology J:48542
abnormal lymph organ size J:48542
abnormal neutrophil morphology J:48542
abnormal neutrophil physiology J:48542
abnormal T cell proliferation J:48542
alopecia J:48542
conjunctivitis J:48542
dermatitis J:48542
enlarged lymph nodes J:48542
enlarged spleen J:48542
epidermal hyperplasia J:48542
increased bone marrow cell number J:48542
increased circulating interleukin-3 level J:48542
increased circulating interleukin-6 level J:48542
increased IgA level J:48542
increased IgG level J:48542
increased IgM level J:48542
increased immunoglobulin level J:48542
increased inflammatory response J:48542
increased leukocyte cell number J:48542
increased lymphocyte cell number J:48542
increased monocyte cell number J:48542
increased neutrophil cell number J:48542
increased susceptibility to bacterial infection J:48542
myeloid hyperplasia J:48542
perinatal lethality, incomplete penetrance J:48542
reddish skin J:48542
Itgb2tm2Bay/Itgb2tm2Bay
involves: 129S7/SvEvBrd * PL/J 		normal integument phenotype J:84126
Itgb2tm2Bay/Itgb2tm2Bay
PL.129S7-Itgb2tm2Bay 		decreased susceptibility to type IV hypersensitivity reaction J:109598
normal integument phenotype J:109598
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory