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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itgb3
integrin beta 3
MGI:96612
83 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
involves: C57BL/6 		no abnormal phenotype detected J:224675
Itgb3tm1Aja/Itgb3tm1Aja
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal platelet activation J:148306
abnormal platelet dense granule physiology J:148306
abnormal platelet physiology J:148306
decreased susceptibility to induced thrombosis J:148306
increased bleeding time J:148306
Itgb3tm1Drp/Itgb3tm1Drp
Not Specified 		abnormal blood coagulation J:73416
Itgb3tm1Hyn/Itgb3+
involves: 129S2/SvPas * C57BL/6 		cardiac hypertrophy J:119666
decreased heart rate J:119666
heart left ventricle hypertrophy J:119666
increased heart left ventricle weight J:119666
increased heart weight J:119666
increased response of heart to induced stress J:119666
Itgb3tm1Hyn/Itgb3tm1.1Wlbcr
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal osteoclast differentiation J:224675
abnormal osteoclast morphology J:224675
abnormal tumor pathology J:224675
abnormal tumor susceptibility J:224675
decreased collagen level J:224675
decreased osteoclast cell number J:224675
increased bone mineral density J:224675
increased trabecular bone volume J:224675
osteopetrosis J:224675
Itgb3tm1Hyn/Itgb3tm1.1Wlbcr
Tg(Pf4-icre)Q3Rsko/0
involves: 129S2/SvPas * C57BL/6 		abnormal blood coagulation J:224675
abnormal hemostasis J:224675
decreased hemoglobin content J:224675
decreased platelet aggregation J:224675
enlarged spleen J:224675
gastrointestinal hemorrhage J:224675
increased bleeding time J:224675
intracranial hemorrhage J:224675
postnatal lethality, incomplete penetrance J:224675
Itgb3tm1Hyn/Itgb3tm1Hyn
involves: 129S2/SvPas 		abnormal osteoclast morphology J:60672
abnormal osteoclast physiology J:60672
abnormal physiological neovascularization J:96049
abnormal platelet physiology J:96049
decreased circulating calcium level J:60672
decreased keratinocyte proliferation J:96049
decreased macrophage cell number J:96049
enhanced wound healing J:96049
increased compact bone thickness J:60672
increased osteoclast cell number J:60672
increased trabecular bone thickness J:60672
increased transforming growth factor beta level J:96049
osteosclerosis J:60672
Itgb3tm1Hyn/Itgb3tm1Hyn
involves: 129S2/SvPas * BALB/c 		normal immune system phenotype J:131241
increased IgG level J:131241
increased miscarriage rate J:131241
maternal effect J:131241
pregnancy-related premature death J:131241
Itgb3tm1Hyn/Itgb3tm1Hyn
involves: 129S2/SvPas * C57BL/6 		abnormal cardiac muscle relaxation J:119666
abnormal cell adhesion J:73752
abnormal cell migration J:73752
abnormal induced retina neovascularization J:73752
abnormal macrophage physiology J:119666
abnormal placenta labyrinth morphology J:52262
abnormal platelet activation J:52262
abnormal trophoblast giant cell morphology J:52262
abnormal tumor vascularization J:73752
abnormal uterine environment J:52262
anemia J:52262
cardiac hypertrophy J:119666
decreased cardiac muscle contractility J:119666
decreased erythrocyte cell number J:52262
decreased heart rate J:119666
decreased hematocrit J:52262
decreased hemoglobin content J:52262
decreased left ventricle systolic pressure J:119666
dermatitis J:52262
enlarged spleen J:52262
extramedullary hematopoiesis J:52262
gastrointestinal hemorrhage J:52262
heart left ventricle hypertrophy J:119666
hemorrhage J:52262
hepatic necrosis J:52262
impaired macrophage chemotaxis J:119666
increased angiogenesis J:73752
increased bleeding time J:52262
increased heart left ventricle weight J:119666
increased heart weight J:119666
increased left ventricle diastolic pressure J:119666
increased miscarriage rate J:52262
increased monocyte cell number J:119666
increased response of heart to induced stress J:119666
increased tumor growth/size J:73752
myositis J:119666
pale placenta J:52262
petechiae J:52262
postnatal lethality, incomplete penetrance J:52262
premature death J:52262
purpura J:52262
reduced female fertility J:52262
renal necrosis J:52262
reticulocytosis J:52262
skin hemorrhage J:52262
uterine hemorrhage J:52262
normal vision/eye phenotype J:52262
Itgb3tm1Mgin/Itgb3tm1Mgin
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal platelet activation J:123968
decreased erythrocyte cell number J:123968
decreased hematocrit J:123968
decreased hemoglobin content J:123968
gastrointestinal hemorrhage J:123968
increased bleeding time J:123968
increased mean corpuscular hemoglobin J:123968
increased mean corpuscular volume J:123968
perinatal lethality, incomplete penetrance J:123968
Itgb3tm2Aja/Itgb3tm2Aja
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:148306
Itgb3tm2Mgin/Itgb3tm2Mgin
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal platelet activation J:123968
abnormal thrombosis J:129707
decreased erythrocyte cell number J:123968
gastrointestinal hemorrhage J:123968
increased bleeding time J:123968
increased mean corpuscular hemoglobin J:123968
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory