Itgb4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itgb4
integrin beta 4
MGI:96613

31 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itgb4^tm1.1Mfel/Itgb4^tm1.1Mfel involves: 129S2/SvPas * C57BL/6	blistering	J:137852
Itgb4^tm1Efu/Itgb4^tm1Efu involves: 129S1/Sv * 129X1/SvJ	normal nervous system phenotype	J:77644
Itgb4^tm1Efu/Itgb4^tm1Efu involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal epidermis stratum basale morphology	J:77644
	abnormal epidermis stratum spinosum morphology	J:77644
	abnormal epidermis suprabasal layer morphology	J:77644
	abnormal esophageal epithelium morphology	J:77644
	abnormal skin condition	J:77644
	abnormal skin physiology	J:77644
	abnormal tongue epithelium morphology	J:77644
	blistering	J:77644
	dermal-epidermal separation	J:77644
	neonatal lethality, complete penetrance	J:77644
	respiratory failure	J:77644
Itgb4^tm1Fgg/Itgb4^tm1Fgg involves: 129S1/Sv * C57BL/6	abnormal enterocyte proliferation	J:48924
	abnormal epidermal layer morphology	J:48924
	abnormal esophageal epithelium morphology	J:48924
	abnormal skin morphology	J:48924
	aphagia	J:48924
	blistering	J:48924
	decreased keratinocyte adhesion	J:48924
	dehydration	J:48924
	dermal-epidermal separation	J:48924
	perinatal lethality, complete penetrance	J:48924
Itgb4^tm1Mfel/Itgb4^tm1.1Mfel Tg(Mpz-cre)26Mes/0 involves: 129S2/SvPas * C57BL/6 * FVB/N	abnormal myelin sheath morphology	J:137852
	normal behavior/neurological phenotype	J:137852
Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0 involves: 129S2/SvPas * C57BL/6 * FVB/N	abnormal myelin sheath morphology	J:137852
	normal behavior/neurological phenotype	J:137852
Itgb4^tm1Son/Itgb4^tm1Son 129P2/OlaHsd-Itgb4^tm1Son	abnormal cornea morphology	J:33713
	abnormal keratinocyte morphology	J:33713
	abnormal nail morphology	J:33713
	abnormal olfactory epithelium morphology	J:33713
	abnormal skin condition	J:33713
	abnormal tongue epithelium morphology	J:33713
	abnormal urinary bladder urothelium morphology	J:33713
	dermal-epidermal separation	J:33713
	edema	J:33713
	normal immune system phenotype	J:33713
	neonatal lethality, complete penetrance	J:33713
	normal nervous system phenotype	J:33713
Itgb4^tm2Fgg/Itgb4^tm2Fgg involves: 129/Sv * C57BL/6	decreased angiogenesis	J:94627
Itgb4^tm2Fgg/Itgb4^tm2Fgg involves: 129/Sv * C57BL/6	normal integument phenotype	J:94627
Itgb4^tm2Son/Itgb4^tm2Son Tg(KRT14-cre)8Brn/0 involves: 129P2/OlaHsd * FVB/N	abnormal keratinocyte morphology	J:96543
	blistering	J:96543
	ear inflammation	J:96543

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24