Itk Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itk
IL2 inducible T cell kinase
MGI:96621

34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cblb^tm1Pngr/Cblb^tm1Pngr Itk^tm1Litt/Itk^tm1Litt B6.129-Itk^tm1Litt Cblb^tm1Pngr	abnormal T cell morphology	J:141390
	abnormal T-helper 2 cell differentiation	J:141390
	decreased interleukin-2 secretion	J:141390
	decreased T cell number	J:141390
	normal immune system phenotype	J:141390
H2^b/H2^b Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/? involves: C3H/HeJ * C57BL/6 * C57BL/10	abnormal positive T cell selection	J:123795
	decreased CD4-positive, alpha-beta T cell number	J:123795
H2^b/H2^k Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/? involves: C3H/HeJ * C57BL/6 * C57BL/10	abnormal positive T cell selection	J:123795
	decreased CD4-positive, alpha-beta T cell number	J:123795
Il4^tm1Lky/Il4^tm1Lky Itk^tm1Litt/Itk^tm1Litt involves: 129S4/SvJae * BALB/c * C57BL/6J	abnormal cell death	J:129883
	abnormal cytokine secretion	J:129883
	abnormal response to infection	J:129883
	abnormal T-helper 2 physiology	J:129883
	normal immune system phenotype	J:129883
Il15^tm1Imx/Il15^tm1Imx Itk^tm1Litt/Itk^tm1Litt involves: 129S4/SvJae * C57BL/6	abnormal thymus cell ratio	J:111786
Il15^tm1Imx/Il15^tm1Imx Itk^tm1Ljb/Itk^tm1Ljb involves: 129 * C57BL/6 * C57BL/10	decreased CD8-positive, alpha-beta T cell number	J:113408
Itk^tm1Litt/Itk^tm1Litt Tg(DO11.10)10Dlo/0 involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J	abnormal T-helper 2 physiology	J:129883
Itk^tm1Litt/Itk^tm1Litt Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: 129S4/SvJae * C57BL/6 * DBA/2J	abnormal positive T cell selection	J:31230
	decreased CD4-positive, alpha-beta T cell number	J:31230
	increased double-positive T cell number	J:31230
Itk^tm1Litt/Itk^tm1Litt Tg(TcrAND)53Hed/0 involves: 129S4/SvJae * C57BL/6 * SJL	abnormal lymphocyte morphology	J:31230
	decreased CD4-positive, alpha-beta T cell number	J:31230
	increased double-negative T cell number	J:31230
Itk^tm1Litt/Itk^tm1Litt Txk^tm1Pls/Txk^tm1Pls involves: 129S4/SvJae * 129S6/SvEvTac	decreased CD4-positive, alpha-beta T cell number	J:54449
	decreased single-positive T cell number	J:54449
	decreased T cell proliferation	J:54449
	increased susceptibility to parasitic infection	J:54449
Itk^tm1Litt/Itk^tm1Litt Vav1^tm2Bbd/Vav1^tm2Bbd B6.129-Itk^tm1Litt Vav1^tm2Bbd	abnormal CD4-positive T cell differentiation	J:141390
	abnormal CD8-positive, alpha-beta T cell differentiation	J:141390
	abnormal positive T cell selection	J:141390
	abnormal T cell morphology	J:141390
	abnormal T cell physiology	J:141390
	decreased CD4-positive, alpha-beta T cell number	J:141390
	decreased CD8-positive, alpha-beta T cell number	J:141390
	decreased double-positive T cell number	J:141390
	decreased T cell number	J:141390
	decreased thymocyte number	J:141390
	increased B cell number	J:141390
	increased T cell apoptosis	J:141390
Itk^tm1Ljb/Itk^tm1Ljb Rag1^tm1Mom/Rag1^tm1Mom Tg(Tcra5CC7,Tcrb5CC7)IWep/? involves: 129 * C57BL/10	abnormal CD4-positive T cell differentiation	J:93606
	decreased interferon-gamma secretion	J:93606
	decreased interleukin-4 secretion	J:93606
	decreased interleukin-5 secretion	J:93606
	decreased interleukin-10 secretion	J:93606
Itk^tm1Ljb/Itk^tm1Ljb Tcrd^tm1Mom/Tcrd^tm1Mom involves: 129 * C57BL/6 * C57BL/10	normal immune system phenotype	J:148531
Itk^tm1Ljb/Itk^tm1Ljb Tg(Tcra2B4)1Mmd/? Tg(Tcrb2B4)1Mmd/? involves: C3H/HeJ * C57BL/6 * C57BL/10	decreased CD4-positive, alpha-beta T cell number	J:123795
Itk^tm1Ljb/Itk^tm1Ljb Tg(Tcra5CC7,Tcrb5CC7)IWep/? involves: 129 * C57BL/10	decreased CD4-positive, alpha-beta T cell number	J:123795
Itk^tm1Ljb/Itk^tm1Ljb Tg(TcraTcrb)1100Mjb/? involves: 129 * C57BL/6 * C57BL/10	normal immune system phenotype	J:113408
Itk^tm1Ljb/Itk^tm1Ljb Txk^tm1Pls/Txk^tm1Pls B6.129-Txk^tm1Pls Itk^tm1Ljb	abnormal CD8-positive, alpha-beta T cell physiology	J:113408
	increased CD8-positive, alpha-beta T cell number	J:113408
	increased interferon-gamma secretion	J:113408
	increased memory T cell number	J:113408

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