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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Jak1
Janus kinase 1
MGI:96628
67 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Jak1M1Mhda/Jak1+
C3HeB/FeJ-Jak1M1Mhda 		abnormal bone resorption J:199153
abnormal bone trabecula morphology J:199153
abnormal circulating creatinine level J:199153
abnormal compact bone morphology J:199153
abnormal dermal layer morphology J:199153
abnormal glomerular mesangium morphology J:199153
abnormal hepatocyte morphology J:199153
abnormal liver morphology J:199153
abnormal liver vasculature morphology J:199153
abnormal outer ear morphology J:199153
abnormal plasma cell morphology J:199153
abnormal tail morphology J:199153
alopecia J:199153
anisocytosis J:199153
decreased birth body size J:199153
decreased body weight J:199153
decreased bone mineral density J:199153
decreased bone trabecula number J:199153
decreased cellular hemoglobin content J:199153
decreased circulating cholesterol level J:199153
decreased circulating parathyroid hormone level J:199153
decreased circulating phosphate level J:199153
decreased circulating serum albumin level J:199153
decreased circulating total protein level J:199153
decreased compact bone volume J:199153
decreased mean corpuscular volume J:199153
decreased mean platelet volume J:199153
decreased megakaryocyte cell number J:199153
decreased triglyceride level J:199153
decreased urine urea nitrogen level J:199153
dilated liver sinusoidal space J:199153
ear inflammation J:199153
enhanced liver regeneration J:199153
enlarged spleen J:199153
hypoglycemia J:199153
increased alkaline phosphatase activity J:199153
increased anti-nuclear antigen antibody level J:199153
increased blood uric acid level J:199153
increased circulating calcium level J:199153
increased erythrocyte cell number J:199153
increased IgA level J:199153
increased IgG1 level J:199153
increased IgG2a level J:199153
increased IgM level J:199153
increased immunoglobulin level J:199153
increased plasma cell number J:199153
liver hyperplasia J:199153
microcytic anemia J:199153
skin inflammation J:199153
skin lesions J:199153
thrombocytopenia J:199153
Jak1M1Mhda/Jak1M1Mhda
C3HeB/FeJ-Jak1M1Mhda/Ieg 		abnormal outer ear morphology J:183993
decreased body size J:183993
decreased circulating phosphate level J:183993
increased circulating alkaline phosphatase level J:183993
increased circulating calcium level J:183993
Jak1tm1.1Kuw/Jak1tm1.1Kuw
involves: 129X1/SvJ * C57BL/6 * FVB 		apnea J:235355
decreased fetal size J:235355
neonatal lethality, complete penetrance J:235355
Jak1tm1Kuw/Jak1tm1Kuw
involves: 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:235355
Jak1tm1Kuw/Jak1tm1Kuw
Tg(MMTV-cre)1Mam/0
involves: 129X1/SvJ * FVB 		abnormal involution of the mammary gland J:235354
Jak1tm1Kuw/Jak1tm1Kuw
Tg(Wap-cre)11738Mam/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal involution of the mammary gland J:235354
Jak1tm1Rds/Jak1tm1Rds
involves: 129 		abnormal B cell differentiation J:47300
abnormal lymphopoiesis J:47300
abnormal suckling behavior J:47300
abnormal T cell differentiation J:47300
arrested B cell differentiation J:47300
decreased B cell number J:47300
decreased body weight J:47300
decreased thymocyte number J:47300
increased double-negative T cell number J:47300
neonatal lethality, complete penetrance J:47300
small thymus J:47300
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory