Jup Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Jup
junction plakoglobin
MGI:96650

94 phenotypes from 10 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Jup^{tm1.1(KOMP)Vlcg}/Jup⁺ C57BL/6N-Jup^{tm1.1(KOMP)Vlcg}/J	decreased circulating phosphate level	J:211773
	decreased coping response	J:211773
	decreased fasting circulating glucose level	J:211773
	impaired righting response	J:211773
	increased hemoglobin content	J:211773
Jup^{tm1.1(KOMP)Vlcg}/Jup^{tm1.1(KOMP)Vlcg} C57BL/6N-Jup^{tm1.1(KOMP)Vlcg}/J	abnormal embryo size	J:211773
	edema	J:211773
	preweaning lethality, complete penetrance	J:211773
Jup^tm1.1Chen/Jup^tm1.1Chen involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal skin physiology	J:222025
	normal cardiovascular system phenotype	J:222025
	loose skin	J:222025
	neonatal lethality, complete penetrance	J:222025
	thin epidermis	J:222025
	wrinkled skin	J:222025
Jup^tm1.1Glr/Jup^tm1.1Glr A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S6/SvEvTac C57BL/6 * FVB/N * SJL	abnormal cardiovascular system physiology	J:170618
	abnormal heart right ventricle morphology	J:170618
	abnormal intercalated disk morphology	J:170618
	abnormal interleukin level	J:170618
	abnormal myocardial fiber morphology	J:170618
	abnormal sarcomere morphology	J:170618
	cardiac fibrosis	J:170618
	normal cardiovascular system phenotype	J:170618
	decreased heart left ventricle muscle contractility	J:170618
	diffuse Z line	J:170618
	dilated heart left ventricle	J:170618
	heart inflammation	J:170618
	heart left ventricle hypertrophy	J:170618
	increased heart left ventricle size	J:170618
	increased heart right ventricle size	J:170618
	increased heart weight	J:170618
	increased myocardial fiber size	J:170618
	premature death	J:170618
	pulmonary edema	J:170618
Jup^tm1.1Shou/Jup^tm1.1Shou Tg(Myh6-cre)2182Mds/0 involves: 129 * C57BL/6J	abnormal cardiovascular system physiology	J:177567
	abnormal heart electrocardiography waveform feature	J:177567
	abnormal heart ventricle morphology	J:177567
	abnormal impulse conducting system conduction	J:177567
	abnormal myocardial fiber morphology	J:177567
	abnormal P wave	J:177567
	calcified myocardium	J:177567
	cardiac fibrosis	J:177567
	cardiac muscle necrosis	J:177567
	cardiomyopathy	J:177567
	decreased cardiac muscle contractility	J:177567
	decreased QRS amplitude	J:177567
	dilated heart	J:177567
	dilated heart right ventricle	J:177567
	enlarged heart	J:177567
	increased cardiomyocyte apoptosis	J:177567
	increased heart right atrium size	J:177567
	liver vascular congestion	J:177567
	premature death	J:177567
	prolonged PR interval	J:177567
	ventricular aneurysm	J:177567
	ventricular tachycardia	J:177567
Jup^tm1.2Glr/Jup^tm1.2Glr involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL	embryonic lethality	J:170618
Jup^tm1Kem/Jup^tm1Kem involves: 129S1/Sv * 129X1/SvJ	abnormal atrioventricular cushion morphology	J:38047
	abnormal blood circulation	J:38047
	abnormal heart atrium morphology	J:38047
	abnormal heart development	J:38047
	absent cardiac desmosomes	J:38047
	embryonic lethality during organogenesis, incomplete penetrance	J:38047
	hemopericardium	J:38047
	small liver	J:38047
	small placenta	J:38047
	thin myocardium	J:38047
	trabecula carnea hypoplasia	J:38047
Jup^tm1Kem/Jup^tm1Kem involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal atrial thrombosis	J:38047
	abnormal atrioventricular cushion morphology	J:38047
	abnormal cardiac thrombosis	J:38047
	abnormal epidermal layer morphology	J:38047
	abnormal epidermis stratum granulosum morphology	J:38047
	abnormal epidermis stratum spinosum morphology	J:38047
	abnormal heart atrium morphology	J:38047
	abnormal heart development	J:38047
	abnormal ventricular thrombosis	J:38047
	absent cardiac desmosomes	J:38047
	absent epidermis stratum corneum	J:38047
	acantholysis	J:38047
	blistering	J:38047
	decreased skin tensile strength	J:38047
	embryonic lethality during organogenesis, incomplete penetrance	J:38047
	enlarged heart	J:38047
	hemopericardium	J:38047
	impaired skin barrier function	J:38047
	normal integument phenotype	J:38047
	small liver	J:38047
	small placenta	J:38047
	thin epidermis	J:38047
	thin myocardium	J:38047
	trabecula carnea hypoplasia	J:38047
Jup^tm1Ruiz/Jup⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal fat cell differentiation	J:192719
	abnormal heart echocardiography feature	J:192719
	thin interventricular septum	J:192719
Jup^tm1Ruiz/Jup⁺ Tg(Myh6-Jup)1Ajm/0 involves: 129P2/OlaHsd C57BL/6 * FVB/N	abnormal cardiovascular system morphology	J:192719
	abnormal fat cell morphology	J:192719
	abnormal heart echocardiography feature	J:192719
	abnormal heart morphology	J:192719
	decreased heart left ventricle muscle contractility	J:192719
	thin interventricular septum	J:192719
Jup^tm1Ruiz/Jup^tm1Ruiz involves: 129P2/OlaHsd	abnormal heart development	J:178688
	embryonic lethality during organogenesis, incomplete penetrance	J:178688
	lethality throughout fetal growth and development, complete penetrance	J:178688
Jup^tm1Ruiz/Jup^tm1Ruiz involves: 129P2/OlaHsd * C57BL/6	abnormal blood circulation	J:64280
	abnormal cardiac muscle contractility	J:64280
	abnormal heart morphology	J:64280
	abnormal intercalated disk morphology	J:64280
	abnormal liver morphology	J:64280
	abnormal spongiotrophoblast layer morphology	J:64280
	absent cardiac desmosomes	J:64280
	decreased spongiotrophoblast size	J:64280
	embryonic growth retardation	J:64280
	hemopericardium	J:64280
	increased heart rate	J:64280
	lethality throughout fetal growth and development, complete penetrance	J:64280
	pallor	J:64280
Jup^tm1Ruiz/Jup^tm1Ruiz Tg(Myh6-Jup)1Ajm/0 involves: 129P2/OlaHsd C57BL/6 * FVB/N	prenatal lethality, complete penetrance	J:192719
Jup^tm2.1Chen/Jup^tm2.1Chen involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:222025
Tg(Myh6-Jup)2Ajm/0 involves: FVB/N	abnormal fat cell morphology	J:192719
	abnormal heart echocardiography feature	J:192719
	abnormal heart morphology	J:192719
	cardiac interstitial fibrosis	J:192719
	premature death	J:192719
Tg(Myh6-Jup*)1Ajm/0 involves: FVB/N	abnormal fat cell differentiation	J:192719
	abnormal fat cell morphology	J:192719
	abnormal heart echocardiography feature	J:192719
	abnormal heart morphology	J:192719
	abnormal heart weight	J:192719
	atrioventricular block	J:192719
	cardiac interstitial fibrosis	J:192719
	decreased heart left ventricle muscle contractility	J:192719
	enlarged heart	J:192719
	irregular heartbeat	J:192719
	premature death	J:192719
	ventricular tachycardia	J:192719

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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